Assignee: Affymax Technologies N.V.

Location: Greenford, GB
No. of patents: 37

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Number	Title	Issue Date
6271232	Collagenase-1 and stromelysin-1 inhibitors, pharmaceutical compositions comprising same and methods of their use Novel inhibitors of metalloproteases, in particular collagenase-1 and stromelysin-1, are disclosed. Such compounds are useful in pharmaceutical compositions and methods for treating or controlling disease states or conditions which involve tissue breakdow...	08/07/2001
6165778	Reaction vessel agitation apparatus A device and method for efficiently synthesizing diverse molecular products on substrates. A parent vessel 200 contains a suspension of substrates. The suspension is pressurized with argon and transferred to a plurality of reaction vessels 201-209 in one ...	12/26/2000
6165717	Method of synthesizing diverse collections of oligomers A general stochastic method for synthesizing random oligomers on particles is disclosed. A further aspect of the invention relates to the use of identification tags on the particles to facilitate identification of the sequence of the monomers in the oligo...	12/26/2000
6156511	Peptide library and screening method A random peptide library constructed by transforming host cells with a collection of recombinant vectors that encode a fusion protein comprised of a DNA binding protein and a random peptide and also encode a binding site for the DNA. binding protein can b...	12/05/2000
6143497	Method of synthesizing diverse collections of oligomers A general stochastic method for synthesizing random oligomers on particles is disclosed. A further aspect of the invention relates to the use of identification tags on the particles to facilitate identification of the sequence of the monomers in the oligo...	11/07/2000
6140493	Method of synthesizing diverse collections of oligomers A general stochastic method for synthesizing random oligomers can be used to synthesize compounds to screen for desired properties. The use of identification tags on the oligomers facilitates identification of oligomers with desired properties....	10/31/2000
6056926	Apparatus and method for parallel coupling reactions A device and method for efficiently synthesizing diverse molecular products on substrates. A parent vessel 200 contains a suspension of substrates. The suspension is pressurized with argon and transferred to a plurality of reaction vessels 201-209 in one ...	05/02/2000
5990112	Inhibitors of metalloproteases pharmaceutical compositions comprising same and methods of their use Novel inhibitors of metalloproteases are disclosed. Such compounds are useful in pharmaceutical compositions and methods for treating or controlling disease states or conditions which involve tissue breakdown, such as rheumatoid arthritis....	11/23/1999
5986047	Peptides that bind to the erythropoietin receptor Peptides of 10 to 40 or more amino acid residues in length and having the sequence X3X4X5GPX6TWX7X8 (SEQ ID NO:252) where each amino acid is indicated by standard one letter abbreviation; X3 is C; X4 is R, H, L, or W; X5 is M, F, or I; X6 is in...	11/16/1999
5932433	Biotinylation of proteins Biotinylation peptides can be fused to other peptides or proteins of interest using recombinant DNA techniques to provide efficient methods for biotinylating the resulting fusion proteins in vivo or in vitro....	08/03/1999
5932579	Collagenase-1 and stromelysin-1 inhibitors, pharmaceutical compositions comprising same and methods of their use Novel inhibitors of metalloproteases, in particular collagenase-1 and stromelysin-1, are disclosed. Such compounds are useful in pharmaceutical compositions and methods for treating or controlling disease states or conditions which involve tissue breakdow...	08/03/1999
5929278	Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use Disclosed are novel inhibitors of metalloproteases, in particular matrix metalloproteases. The disclosed inhibitors are mercaptoketone and mercaptoalcohol compounds which are useful in pharmaceutical compositions and methods for treating or controlling di...	07/27/1999
5922545	In vitro peptide and antibody display libraries Improved methods and novel compositions for identifying peptides and single-chain antibodies that bind to predetermined receptors or epitopes. Such peptides and antibodies are identified by improved and novel methods for affinity screening of polysomes di...	07/13/1999
5917016	Photolabile compounds and methods for their use Novel compounds are provided which are useful as photocleavable linking groups in solid phase synthesis. Compositions incorporating these linking groups and methods for their use are also described....	06/29/1999
5880096	Peptides and compounds that bind to the IL-1 receptor Peptides that bind to the interleukin-1 type I receptor (IL-1RtI) can be used to assay the amount of IL-1R, or an IL-1R agonist or antagonist, in a sample and comprise a sequence of amino acids selected from the group consisting of (1) WXXXGZ1 ...	03/09/1999
5874239	Biotinylation of proteins Biotinylation peptides can be fused to other peptides or proteins of interest using recombinant DNA techniques to provide efficient methods for biotinylating the resulting fusion proteins in vivo or in vitro....	02/23/1999
5861476	Peptides and compounds that bind to the IL-1 receptor Peptides that bind to the interleukin-1 type I receptor (IL-1RtI) can be used to assay the amount of IL-1R, or an IL-1R agonist or antagonist, in a sample and comprise a sequence of amino acids selected from the group consisting of (1) WXXXGZ1 ...	01/19/1999
5840698	Inhibitors of collagenase-1 and stormelysin-I metalloproteases, pharmaceutical compositions comprising same and methods of their use Disclosed are novel inhibitors of collagenase-1 and stromelysin-I metalloproteases. The disclosed inhibitors are mercaptoketone and mercaptoalcohol compounds which are useful in pharmaceutical compositions and methods for treating or controlling disease s...	11/24/1998
5831004	Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use Disclosed are novel inhibitors of metalloproteases, in particular matrix metalloproteases. The disclosed inhibitors are mercaptoketone and mercaptoalcohol compounds which are useful in pharmaceutical compositions and methods for treating or controlling di...	11/03/1998
5830851	Methods of administering peptides that bind to the erythropoietin receptor Peptides of 10 to 40 or more amino acid residues in length and having the sequence X3 X4 X5 GPX6 TWX7 X8 (SEQ ID NO:252) where each amino acid is indicated by standard one letter abbreviati...	11/03/1998
5817751	Method for synthesis of diketopiperazine and diketomorpholine derivatives The present invention relates to the areas of organic and medicinal chemistry. More specifically, the present invention is concerned with combinatorial and solid phase methods for the synthesis of diverse diketopiperazine derivatives, and the use of such ...	10/06/1998
5814603	Compounds with PTH activity PTH analogs comprising an amino acid sequence that is: SVSEIQLLHNX1 X2 X3 HX4 X3 X3 X3 X5 RVX5 WLR X4 X4 LX3 X3 VX	09/29/1998
5789162	Methods of synthesizing diverse collections of oligomers A general stochastic method for synthesizing random oligomers on particles is disclosed. A further aspect of the invention relates to the use of identification tags on the particles to facilitate identification of the sequence of the monomers in the oligo...	08/04/1998
5786322	Peptides and compounds that bind selectins including endothelium leukocyte adhesion molecule 1 Disclosed are peptides and peptide mimetics that bind selectins, including endothelial leukocyte adhesion molecule 1 (ELAM-1). Such peptides and peptide mimetics are useful in methods for blocking adhesion of leukocytes to the selectins for the purpose of...	07/28/1998
5786331	Peptides and compounds that bind to the IL-1 receptor Peptides that bind to the interleukin-1 type I receptor (IL-1RtI) can be used to assay the amount of IL-1R, or an IL-1R agonist or antagonist, in a sample and comprise a sequence of amino acids selected from the group consisting of (1) WXXXGZ1 ...	07/28/1998
5773569	Compounds and peptides that bind to the erythropoietin receptor Peptides of 10 to 40 or more amino acid residues in length and having the sequence X3 X4 X5 GPX6 TWX7 X8 (SEQ ID NO:252) where each amino acid is indicated by standard one letter abbreviati...	06/30/1998
5770358	Tagged synthetic oligomer libraries A general stochastic method for synthesizing random oligomers can be used to synthesize compounds to screen for desired properties. The use of identification tags on the oligomers facilitates identification of oligomers with desired properties....	06/23/1998
5767234	Peptides and compounds that bind to the IL-1 receptor Peptides that bind to the interleukin-1 type I receptor (IL-1RtI) can be used to assay the amount of IL-1R, or an IL-1R agonist or antagonist, in a sample and comprise a sequence of amino acids selected from the group consisting of (1) WXXXGZ1 ...	06/16/1998
5739386	Photolabile compounds and methods for their use Novel compounds are provided which are useful as photocleavable linking groups in solid phase synthesis. Compositions incorporating these linking groups and methods for their use are also described....	04/14/1998
5733731	Peptide library and screening method A random peptide library constructed by transforming host cells with a collection of recombinant vectors that encode a fusion protein comprised of a DNA binding protein and a random peptide and also encode a binding site for the DNA binding protein can be...	03/31/1998
5728802	Peptides and compounds that bind selectins including endothelium leukocyte adhesion molecule 1 (ELAM-1) Disclosed are peptides and peptide mimetics that bind selectins, including endothelial leukocyte adhesion molecule 1 (ELAM-1). Such peptides and peptide mimetics are useful in methods for blocking adhesion of leukocytes to the selectins for the purpose of...	03/17/1998
5723286	Peptide library and screening systems Peptides which bind to selected receptor molecules are identified by screening libraries which encode a random or controlled collection of amino acids. Peptides encoded by the libraries are expressed as fusion proteins of bacteriophage coat proteins, and ...	03/03/1998
5723584	Biotinylation of proteins Biotinylation peptides can be fused to other peptides or proteins of interest using recombinant DNA techniques to provide efficient methods for biotinylating the resulting fusion proteins in vivo or in vitro....	03/03/1998
5708153	Method of synthesizing diverse collections of tagged compounds A general stochastic method for synthesizing random oligomers on particles is disclosed. A further aspect of the invention relates to the use of identification tags on the particles to facilitate identification of the sequence of the monomers in the oligo...	01/13/1998
5679773	Reagants and methods for immobilized polymer synthesis and display Compounds and methods for solid phase synthesis of organic molecules including peptides, oligonucleotides, benzodiazepines, ଲ-turn mimetics, and prostaglandins. The present invention provides new reagents in the form of linking groups and resins and...	10/21/1997
5668110	Peptides and compounds that bind to the IL-5 receptor Described are peptides and peptide mimetics that bind to and the IL-5 receptor. Such peptides and peptide mimetics are useful in methods for treating disorders that involve improper production of or response to IL-5 and or the production and accumulation ...	09/16/1997
5654276	Peptides and compounds that bind to the IL-5 receptor Described are peptides and peptide mimetics that bind to and the IL-receptor. Such peptides and peptide mimetics are useful in methods for treating disorders that involve improper production of or response to IL-5 and or the production and accumulation of...	08/05/1997

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Assignee: Affymax Technologies N.V.