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Assignee: Aeras Global TB Vaccine Foundation


Location: Bethesda, MD
No. of patents: 4

NumberTitleIssue Date
7829104Electroporation of and overexpression of antigens in mycobacteria
Recombinant Mycobacterium strains with improved vaccinal properties for use as vaccinating agents are provided. The parent strains of the recombinant Mycobacterium strains are selected for their potent immunogenicity. The Mycobacterium strains d...
11/09/2010
7666656Recombinant BCG strains with enhanced ability to escape the endosome
Mycobacterium strains that have an enhanced ability to elicit a MHC-Class I-restricted CD8+ T cell immune response are provided. The Mycobacterium strains are genetically engineered to express: a endosomolytic protein that is active at neutr...
02/23/2010
7625572Transformed bacterium lacking selectable marker and overexpression of antigens in mycobacteria
Recombinant Mycobacterium strains with improved vaccinal properties for use as vaccinating agents are provided. The parent strains of the recombinant Mycobacterium strains are selected for their potent immunogenicity. The Mycobacterium strains d...
12/01/2009
7608256Methods to increase transgene expression from bacterial-based delivery systems by co-expressing suppressors of the eukaryotic type I interferon response
Bacterial delivery systems with improved transgene expression are provided. The recombinant bacterial delivery systems deliver transgenes of interest and suppressors of the eukaryotic Type I interferon response to eukaryotic cells. Suppression of the eukaryotic Type...
10/27/2009
 
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