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| Number | Title | Issue Date |
| 7348005 | Oral tolerance induction by collagen to prevent allograft rejection The present invention relates to the use of collagen and MHC-like compounds to down regulate immune responses. Methods for administration of such compounds that induce immune tolerance are described. The invention is important in the context of allograft rejection, ... | 03/25/2008 |
| 7314618 | Antibodies to fibroblast growth factor (FGF23) The present invention relates to antibodies that bind to FGF23 polypeptides and to FGF23 mutant polypeptides. ... | 01/01/2008 |
| 7223563 | Fibroblast growth factor (FGF23) nucleic acids The invention relates to novel nucleic acids encoding a fibroblast growth factor-23(FGF23) and proteins encoded thereby, mutations in which are associated with autosomal dominant rickets (ADHR). The invention further relates to methods of diagnosing and treating hyp... | 05/29/2007 |
| 7097988 | Methods for screening for substances that bind opioid receptors The invention relates generally to compositions of and methods for obtaining mu opioid receptor polypeptides. The invention relates as well to polynucleotides encoding mu opioid receptor polypeptides, the recombinant vectors carrying those sequences, the recombinant... | 08/29/2006 |
| 6987132 | Enediyne compounds and methods related thereto The invention provides novel tetradentate enediyne ligands that are themselves thermally stable, yet react at about room temperature or slightly higher upon addition of metal ions or under photothermal conditions. In another aspect of the invention, a method of trea... | 01/17/2006 |
| 6905076 | High temperature incubation system and method for small volumes A system and method of incubating a liquid is provided. The system is well-suited for incubating small volumes of liquid at high temperatures. The liquid may be a reaction mixture comprising a glycoprotein. During the incubation process, oligosaccharides may be remo... | 06/14/2005 |
| 6905210 | Methods and systems for measuring local scattering and aberration properties of optical media Methods, systems, and media relating the display of scattering and/or absorption characteristics of an optical medium. For scattering measurements, a Hartmann-Shack calibration image of a measurement system is acquired to define a first plurality of point spread fun... | 06/14/2005 |
| 6858135 | Hydrophilic monolithic columns for separation of saccharide mixtures Polar, monolithic CEC columns having an amine and/or cyano functional stationary phase are used to separate complex mixtures of saccharides. Using the positive-ion mode of detection for neutral saccharides, detection conditions were optimized to low-femtomole sensit... | 02/22/2005 |
| 6828439 | Compounds, composition, and methods for photodynamic therapy Disclosed are novel compounds, compositions, and methods that are particularly useful in photodynamic therapy. In particular, the inventive compounds, compositions, and methods relate to the formation of cytotoxic radical species in the presence of light. Significan... | 12/07/2004 |
| 6737054 | Myocardial grafts and cellular compositions useful for same Described are preferred myocardial grafts of skeletal myoblasts or cardiomyocytes, and cellular compositions and methods useful in obtaining the grafts. The myocardial grafts are stable and can be used, for example, to deliver recombinant proteins directly to the he... | 05/18/2004 |
| 6699491 | Method for modulating glutamate and/or aspartate release in a central nervous system locus Methods and compositions are disclosed for providing prolonged-release of therapeutic agents by way of in situ stereotaxic implantation in specific loci, including pathways, to treat known disorders. One or more microstructures comprising therapeutic agen... | 03/02/2004 |
| 6670177 | Methods for enhanced virus-mediated DNA transfer using molecules with virus-and cell-binding domains A method to increase the efficiency of transduction of hematopoietic and other cells by retroviruses includes infecting the cells in the presence of fibronectin or fibronectin fragments. The fibronectin and fibronectin fragments significantly enhance retr... | 12/30/2003 |
| 6627879 | Voltage pulser circuit One illustrative embodiment of a voltage pulser circuit comprises a voltage source producing a first voltage, and a thyratron tube having an anode coupled to the output of the voltage source, a cathode connected to a reference potential and a grid respons... | 09/30/2003 |
| 6610202 | Arrangement and method for performing chromatography An arrangement for performing chromatography with a mobile phase and a chromatographic bed having a stationary phase is provided. The arrangement includes a support assembly configured to support the stationary phase. The support assembly has a sealed cav... | 08/26/2003 |
| 6604681 | Evaluative shopping assistant system Evaluative shopping assistant system and method to provide the consumer with information about a product the consumer is interested in. The system includes a hand-held device having a bar code reader or other unique means of entering a product identifier,... | 08/12/2003 |
| 6573296 | Therapeutic quassinoid preparations with antineoplastic, antiviral, and herbistatic activity The present invention includes purified and isolated quassinoids and synthetically derived quassinoid analogs based on a picrasane carbon skeleton. Novel sidechains at C-15 incorporating water solubilizing agents such as glycine are discussed. Therapeutic... | 06/03/2003 |
| 6561992 | Method and apparatus utilizing computational intelligence to diagnose neurological disorders A method of diagnosing patients suspected of having a neurological disorder is disclosed and includes monitoring movement of a patient in order to obtain movement data that is representative of the movement of the patient. Another step of the method inclu... | 05/13/2003 |
| 6556199 | Method and apparatus for fast voxelization of volumetric models The present invention relates to an apparatus and method for voxelizing geometric and volumetric models of objects in 3D space, i.e. converting these 3D models into a voxel-based volume representation. Based on an unconventional way of using the 3D graphi... | 04/29/2003 |
| 6526936 | Partitioned multi-channel combustor A multi-channel combustion device is provided. The device includes an inlet port, at least one radially partitioned inlet zone within the inlet port, and a plurality of circumferentially spaced combustion chambers in which deflagrative or detonative combu... | 03/04/2003 |
| 6524485 | Polymer-micelle complexes and methods of use thereof A polymer-micelle complex is disclosed. The polymer-micelle complex includes a micelle having a negative charge. The negatively charged micelle is bound electrostatically to a polymer bearing a positive charge. The complex can be in turn electrostatically... | 02/25/2003 |
| 6514995 | Enediyne compounds and methods related thereto The invention provides novel tetradentate enediyne ligands that are themselves thermally stable, yet react at about room temperature or slightly higher upon addition of metal ions or under photothermal conditions. In another aspect of the invention, a met... | 02/04/2003 |
| 6500652 | Use of nucleic acid molecules as antiviral agents The invention provides antiviral compounds and compositions comprising a viral specific oligonucleotide. Also provided are methods to inhibit or treat viral infections with the compounds or compositions of the invention.... | 12/31/2002 |
| 6491939 | Pharmacotherapeutic process and composition for central nervous system disorders Methods and compositions are disclosed for providing prolonged-release of therapeutic agents by way of in situ stereotaxic implantation in specific loci, including pathways, to treat known disorders. One or more microstructures comprising therapeutic agen... | 12/10/2002 |
| 6468808 | Water-soluble luminescent quantum dots and biomolecular conjugates thereof and related compositions and method of use The present invention provides a water-soluble luminescent quantum dot, a biomolecular conjugate thereof and a composition comprising such a quantum dot or conjugate. Additionally, the present invention provides a method of obtaining a luminescent quantum... | 10/22/2002 |
| 6437325 | System and method for calibrating time-of-flight mass spectra A time-of-flight mass spectra calibration technique uses time-of-flight mass spectrometer instrument operational parameters and known mass and measured time-of-flight data pairs to optimize values of chosen ones of the instrument operational parameters. E... | 08/20/2002 |
| 6406917 | Methods and compositions for the use of apurinic/apyrimidinic endonucleases Disclosed are methods and compositions for identifying, monitoring and treating premalignant and malignant conditions in a human subject. The present invention further discloses methods and compositions for determining cells undergoing apoptosis, and for ... | 06/18/2002 |
| 6405071 | Three dimensional imaging and analysis of a root canal A computer-based imaging technique for three dimensional modeling of root canal shape and accurate measuring of root canal length is provided. A direct digital radiology (DDR) system that replaces film by an electronic sensor is used to acquire radiograph... | 06/11/2002 |
| 6399335 | γ-phosphoester nucleoside triphosphates The invention provides methods and compositions for polymerizing a particular nucleotide with a polymerase. In general, the method involves (a) forming a mixture of a polymerase and a nucleoside triphosphate (NTP) comprising , ଲ and γ phosph... | 06/04/2002 |
| 6383734 | Method to determine inhibition of PAK3 activation of Raf-1 A method is provided to determine the ability of a test compound to alter PAK activation of Raf-1 comprising: (a) contacting a polypeptide comprising the catalytic domain of a PAK with the test compound in the presence of Raf-1; and (b) measuring the exte... | 05/07/2002 |
| 6362325 | Murine 4-1BB gene The present invention includes the receptor protein 4-1BB and the cDNA gene encoding for receptor protein 4-1BB. The nucleotide sequence of the isolated cDNA is disclosed herein along with the deduced amino acid sequence. The 4-1BB protein and fragments a... | 03/26/2002 |
| 6355476 | Nucleic acid encoding MIP-1 Lymphokine Full length cDNAs, L2G25B and 4-1BB, were isolated and sequenced. The cDNA L2G25B encodes for the lymphokine, macrophage inflammatory protein-1 or MIP-1. The studies disclosed herein suggest that MIP-1 and MIP-ଲ can, through rap... | 03/12/2002 |
| 6323482 | Ion mobility and mass spectrometer An ion mobility and mass spectrometer instrument includes an ion source region coupled to an ion mobility spectrometer having an ion outlet coupled to a quadrupole mass filter. An output of the filter is coupled to a collision cell which has an ion outlet... | 11/27/2001 |
| 6303121 | Method of using human receptor protein 4-1BB Disclosed herein are the methods of using the H4-1BB protein, ligands to this protein, and various mAbs either directed against H4-1BB or other molecules that can be used therapeutically. The nature and importance of the H4-1BB molecule provides the ligan... | 10/16/2001 |
| 6303134 | Pharmacotherapeutic process and composition for central nervous system disorders Methods and compositions are disclosed for providing prolonged release of therapeutic agents by way of in situ stereotaxic implantation in specific loci, including pathways, to treat known disorders. One or more microstructures comprising therapeutic agen... | 10/16/2001 |
| 6252048 | DNA sequences encoding fusions of DNA repair proteins and uses thereof Described are DNA-repair fusion proteins of multiple, complementary DNA repair proteins and having the activity of each protein, and related polynucleotides and vectors. The proteins, when expressed in cells, e.g., hematopoietic cells, increase the surviv... | 06/26/2001 |
| 6225075 | DNA encoding sterol methyltransferase The invention provides an isolated and purified nucleic acid molecule encoding a Candida albicans sterol methyltransferase (ERG6). Also provided is a C. albicans strain or isolate that has reduced levels of sterol methyltransferase as a result of the disr... | 05/01/2001 |
| 6213976 | Brachytherapy guide catheter A guide catheter includes a body and a centering mechanism. The body has an elongatable section and a lumen with a stop. The centering mechanism is a plurality of bias elements that forms a self-expanding basket attached to the body so that the elongatabl... | 04/10/2001 |
| 6200302 | Hypodermic needle for percutaneous drug delivery Devices and methods are disclosed for the percutaneous administration of a composition to a desired in vivo location. The composition comprises a biologically active substance and a pharmaceutically acceptable carrier. The pharmaceutically acceptable carr... | 03/13/2001 |
| 6187044 | Implant filler materials and methods comprising nonionic surfactants Compositions and methods are disclosed for filling prostheses for implantation into human soft tissue. The compositions comprise at least one nonionic surfactant, such as a polysorbate, which can be provided to fill a physiologically compatible shell or c... | 02/13/2001 |
| 6120287 | Apparatus and method for measuring orthodontic force applied by an orthodontic appliance An orthodontic force measuring apparatus includes a dental replica which includes a first tooth replica and a second tooth replica. The first tooth replica is moveable relative to the second tooth replica. The apparatus also includes an orthodontic applia... | 09/19/2000 |
