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| Number | Title | Issue Date |
| 6238705 | Bioerodible porous compositions A composition for the sequestration and sustained delivery of an active ingredient in the form of porous particles, the composition comprising the product of the controlled dehydration of particles formed by the reaction of a polymeric anionic material wi... | 05/29/2001 |
| 6096344 | Bioerodible porous compositions A composition for the sequestration and sustained delivery of an active ingredient in the form of porous particles, the composition comprising the product of the controlled dehydration of particles formed by the reaction of a polymeric anionic material wi... | 08/01/2000 |
| 5968543 | Polymers with controlled physical state and bioerodibility Polymers useful as orthopedic implants or vehicles for the sustained delivery of pharmaceutical, cosmetic and agricultural agents are prepared in such a manner that the rate and degree to which they are hydrolyzed can be controlled without addition of exo... | 10/19/1999 |
| 5955109 | Methods and compositions for topical delivery of retinoic acid Retinoic acid compositions intended for topical application are incorporated in novel formulations in which they are retained as impregnants inside the pores of porous solid particles or microspheres. The pores form a continuous network open to the exteri... | 09/21/1999 |
| 5939453 | PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers have both hydrophilic and hydrophobic blocks. They form micelles in aqueous solution, making them suitable for encapsulation or solubilization of hydrophobic or water-insoluble materials; and they als... | 08/17/1999 |
| 5891470 | Softgel formulation containing retinol A softgel formulation containing retinol comprises a soft gelatin shell and a fill material within that shell containing retinol-impregnated microparticles. The fill material may be an optionally thickened silicone oil, or may be an emulsion comprising a ... | 04/06/1999 |
| 5879716 | Methods and compositions for topical delivery of benzoyl peroxide Benzoyl peroxide intended for topical application is incorporated in novel formulations in which it is retained as impregnants inside the pores of porous solid particles or microspheres. The pores form a continuous network open to the exterior of the part... | 03/09/1999 |
| 5871722 | Ionic beads useful for controlled release and adsorption Ionic compositions comprise an active ingredient absorbed within a network of internal pores defined by a plurality of polymeric particles. The particles are preferably crosslinked polymeric beads having a diameter in the range from about 5 to 100 microns... | 02/16/1999 |
| 5851538 | Retinoid formulations in porous microspheres for reduced irritation and enhanced stability Retinoids for topical skin application are formulated as impregnants in porous microspheres. Thus formulated, the retinoids display a surprisingly high level of stability and low degree of skin irritation.... | 12/22/1998 |
| 5849327 | Delivery of drugs to the lower gastrointestinal tract Diseases of the colon are treated by oral ingestion of a unit dosage form containing a plurality of porous microscopic beads, the pores containing an active agent or drug and plugged with a polysaccharide that is chemically degradable by colon-specific ba... | 12/15/1998 |
| 5840293 | Ionic beads for controlled release and adsorption Ionic compositions comprise an active ingredient absorbed within a network of internal pores defined by a plurality of polymeric particles. The particles are preferably crosslinked polymeric beads having a diameter in the range from about 5 to 100 microns... | 11/24/1998 |
| 5510116 | Pressurized product delivery systems An apparatus for dispensing pressurized material is comprised of a container, a polymeric matrix having a network of macropores located within the container, and a propellant that may be reversibly sorbed with the network of macropores so as to desorb as ... | 04/23/1996 |
| 5458890 | Methods and compositions for flavoring orally-delivered products Flavored food and pharmaceutical compositions include one or more flavor additives incorporated within polymeric particles, usually within an internal pore network defined by individual polymeric particles. The polymeric particles are, in turn, dispersed ... | 10/17/1995 |
| 5316774 | Blocked polymeric particles having internal pore networks for delivering active substances to selected environments A composition for the controlled release of an active substance comprises a polymeric particle matrix, where each particle defines a network of internal pores. The active substance is entrapped within the pore network together with a blocking agent having... | 05/31/1994 |
| 5261169 | System and method for deodorant delivery in footwear An article for the pressure-actuated release of the powder composition comprises a resilient layer having a plurality of discrete reservoirs therein. Each reservoir contains an isolated quantity of an active powder composition, and usually a permeable lay... | 11/16/1993 |
| 5256400 | Pressurized product delivery systems An apparatus for dispensing pressurized material is comprised of a container, a polymeric matrix having a network of macropores located within the container, and a propellant that may be reversibly sorbed with the network of macropores so as to desorb as ... | 10/26/1993 |
| 5240715 | Color modified melanins and methods for their preparation and use Color modified melanin compositions are produced by exposure of a natural or synthetic melanin starting material to a color modifying agent under controlled conditions. By treating the melanin starting materials for a preselected time period, melanin prod... | 08/31/1993 |
| 5188844 | Color modified melanins and methods for their preparation and use Color modified melanin compositions are produced by exposure of a natural or synthetic melanin starting material to a color modifying agent under controlled conditions. By treating the melanin starting materials for a preselected time period, melanin prod... | 02/23/1993 |
| 5156843 | Fabric impregnated with functional substances for controlled release Intersticed materials, including woven and nonwoven fabrics, open-cellular materials and the like, are impregnated with functional substances by incorporating the substances in microscopic porous particles in which the pores form an interconnected network... | 10/20/1992 |
| 5145675 | Two step method for preparation of controlled release formulations Active substances intended for topical application are incorporated in novel formulations in which they are retained as impregnants inside the pores of porous solid particles or microspheres. The pores form a continuous network open to the exterior of the... | 09/08/1992 |
| 5135740 | Porous particles in preparations involving immiscible phases Immiscible phases, particularly polar and non-polar liquids, semi-solids or solids, are combined in a composition where one is finely dispersed throughout the other without reliance upon emulsifying agents to either create or stabilize the dispersion. The... | 08/04/1992 |
| 5073365 | Clinical and personal care articles enhanced by lubricants and adjuvants Articles for use in contact with animal tissue, such as surgical and first aid supplies, health care products and personal hygiene products, are dusted with microspheres for lubricating purposes or for the application of diffusible adjuvants. In the latte... | 12/17/1991 |
| 5028435 | System and method for transdermal drug delivery Transdermal drug delivery systems comprise a backing or enclosure having a matrix layer which incorporates a drug and a percutaneous enhancer for the drug. The percutaneous enhancer and/or drug will be contained within polymeric particles dispersed throug... | 07/02/1991 |
| 4873091 | Controlled release formulating employing resilient microbeads Microscopic particles containing a continuous network of pores open to the particle surface are manufactured of a spongy material. The particles are useful as controlled-release delivery systems for active substances intended for a wide range of uses incl... | 10/10/1989 |
| 4855144 | Synthetic melanin aggregates Melanin compositions include a melanin pigment incorporated within polymeric particles, usually within an internal pore network defined by a polymeric particle matrix. The melanin compositions may be produced by in situ oxidation of melanin precursors wit... | 08/08/1989 |
| 4806360 | Synthetic melanin aggregates Melanin compositions include a melanin pigment incorporated within an internal pore network defined by a polymeric particle matrix. The melanin compositions may be produced by in situ oxidation of melanin precursors within the pore network, or by absorpti... | 02/21/1989 |
| 4738932 | Reaginic test for syphilis A reaginic agglutination test for syphilis-associated antibodies is disclosed. The test uses an antigen reagent that comprises a buffered aqueous suspension of cardiolipin antigen ionically coupled to latex particles via a polypeptide bridge. Positive ser... | 04/19/1988 |
| 4690825 | Method for delivering an active ingredient by controlled time release utilizing a novel delivery vehicle which can be prepared by a process utilizing the active ingredient as a porogen Delivery vehicles comprised of a polymeric bead having a network of pores with an active ingredient held within the network are provided for use in a method to provide controlled release of the active ingredient. The network of pores is substantially non-... | 09/01/1987 |
