Assignee: Advanced Inhalation Research, Inc.

Location: Cambridge, MA
No. of patents: 22

Number	Title	Issue Date
7384649	Particulate compositions for pulmonary delivery This invention concerns an improved particulate composition for delivering a drug to the pulmonary system. Applicants disclose a method of identifying an optimal form of aerodynamically light particles which are highly dispersible. The particles of the instant inven...	06/10/2008
7279182	Formulation for spray-drying large porous particles Particles having a tap density less than about 0.4 g/cm3 are formed by spray drying from a colloidal solution including a carboxylic acid or salt thereof, a phospholipid, a divalent salt and a solvent such as an aqueous-organic solvent. The colloidal solution can al...	10/09/2007
7252840	Use of simple amino acids to form porous particles Particles having a tap density of less than 0.4 g/cm3 include a hydrophobic amino acid or salt thereof and a therapeutic, prophylactic or diagnostic agent or any combination thereof. Preferred particles include a phospholipid, have a median geometric diam...	08/07/2007
7182961	Particulate compositions for pulmonary delivery This invention concerns an improved particulate composition for delivering a drug to the pulmonary system. Applicants disclose a method of identifying an optimal form of aerodynamically light particles which are highly dispersible. The particles of the instant inven...	02/27/2007
7146978	Inhalation device and method Inhalation device and associated method for facilitating inhalation by a patient of powder medicaments contained in a receptacle. The inhalation device has a chamber for receiving the receptacle. A ring is circumferentially coupled to an inner surface of the chamber...	12/12/2006
7048908	Particles for inhalation having sustained release properties The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention rel...	05/23/2006
7032593	Inhalation device and method Inhaler and associated method for facilitating inhalation of dry powder medicaments by a patient. The inhaler is light and compact, allowing for convenient storage and portability by a patient. Additionally, a minimal number of steps are required by the patient to u...	04/25/2006
7008644	Method and apparatus for producing dry particles Method and apparatus for producing dry particles. Two liquid components are combined in a static mixer, atomized into droplets, and the droplets dried to form dry particles. Use of the static mixer enables incompatible liquid components to be rapidly and homogeneous...	03/07/2006
6979437	Pulmonary delivery in treating disorders of the central nervous system A method for treating a disorder of the central nervous system includes administering to the respiratory tract of a patient a drug which is delivered to the pulmonary system, for instance to the alveoli or the deep lung. The drug is administered at a dose which is a...	12/27/2005
6959522	System for filling containers Method and apparatus for providing a precisely controlled amount of dry material to a container. In one embodiment, a system is provided for automated container filling. The system includes a container handling mechanism that includes a container block defining a co...	11/01/2005
6956021	Stable spray-dried protein formulations Spray-dried particles having improved protein stability are produced by spray-drying a mixture including a protein, a phospholipid and an organic-aqueous co-solvent. Spray-dried particles which include at least 1 weight % phospholipid, having a tap density of less t...	10/18/2005
6921528	Highly efficient delivery of a large therapeutic mass aerosol A method for delivering a therapeutic dose of a bioactive agent to the pulmonary system, in a single, breath-activated step, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density...	07/26/2005
6858199	High efficient delivery of a large therapeutic mass aerosol A method for delivering a therapeutic dose of a bioactive agent to the pulmonary system, in a single, breath-activated step, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density...	02/22/2005
6848197	Control of process humidity to produce large, porous particles Spray dried particles having specified aerodynamic characteristics are produced by atomizing a liquid feed and contacting the liquid feed with a drying gas, such as, for example, air or nitrogen. The humidity of the drying gas is controlled to a value, expressed, fo...	02/01/2005
6766799	Inhalation device Inhalation device and associated method for facilitating inhalation by a patient of powder medicaments contained in a receptacle. The inhalation device has a chamber for receiving the receptacle. A ring is circumferentially coupled to an inner surface of the chamber...	07/27/2004
6749835	Formulation for spray-drying large porous particles Particles having a tap density less than about 0.4 g/cm3 are formed by spray drying from a colloidal solution including a carboxylic acid or salt thereof, a phospholipid, a divalent salt and a solvent such as an aqueous-organic solvent. The colloidal solution can al...	06/15/2004
6732732	Inhalation device and method Inhalation device and associated method for facilitating inhalation by a patient of powder medicaments contained in a receptacle. The inhalation device has a chamber for receiving the receptacle. A ring is circumferentially coupled to an inner surface of the chamber...	05/11/2004
6715259	System for filling containers Method and apparatus for providing a precisely controlled amount of dry material to a container. In one embodiment, a system is provided for automated container filling. The system includes a container handling mechanism that includes a container block defining a co...	04/06/2004
6613308	Pulmonary delivery in treating disorders of the central nervous system A method for treating a disorder of the central nervous system includes administering to the respiratory tract of a patient a drug which is delivered to the pulmonary system, for instance to the alveoli or the deep lung. The drug is administered at a dose...	09/02/2003
6586008	Use of simple amino acids to form porous particles during spray drying Particles having a tap density of less than 0.4 g/cm3 include a hydrophobic amino acid or salt thereof and a therapeutic, prophylactic or diagnostic agent or any combination thereof. Preferred particles include a phospholipid, have a median geometric diam...	07/01/2003
6514482	Pulmonary delivery in treating disorders of the central nervous system A method of pulmonary delivery of a medicament, for example a dopamine precursor or a dopamine agonist, which includes administering to the respiratory tract of a patient in need of rescue therapy particles comprising an effective amount of a medicament. ...	02/04/2003
6357490	System, method and apparatus for filling containers Method and apparatus for providing a precisely controlled amount of dry material to a container. A powder slug is formed, preferably under vacuum, in a dosing hole formed in a dosing plate. The powder slug represents a precisely metered amount of material...	03/19/2002

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Assignee: Advanced Inhalation Research, Inc.