Assignee: Adolor Corporation

Location: Exton, PA
No. of patents: 40

Number	Title	Issue Date
8112290	Methods for delivering a drug to a hospital patient for short-term use while minimizing long-term use of the drug Novel methods for delivering a drug to hospital patients for short-term in-hospital use while minimizing long-term use of the drug. Embodiments are provided in which hospitals are identified which may be eligible to treat patients, for example, perform certain types...	02/07/2012
8071611	Spirocyclic heterocyclic derivatives and methods of their use Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the δ opioid receptor and may be us...	12/06/2011
8022060	Spirocyclic heterocyclic derivatives and methods of their use Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the δ opioid receptor and may be us...	09/20/2011
7914776	Solid dispersions of opioid antagonists Solid dispersions of stable, amorphous opioid antagonists, particularly [[2(S)-[[4(R)-(3-hydroxyphenyl)-3(R),4-dimethyl-piperidinyl]methyl]-1-oxo-3-phenylpropyl]amino]acetic acid, with improved water solubility and bioavailability are disclosed. Also disclosed are m...	03/29/2011
7906646	Spirocyclic heterocyclic derivatives and methods of their use Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the δ opioid receptor and may be us...	03/15/2011
7884102	Substituted piperidine compounds and methods of their use 3,4-Disubstituted-4-aryl-piperidine compounds are disclosed. Pharmaceutical compositions containing the 3,4-disubstituted-4-aryl-piperidine compounds and methods of their pharmaceutical uses are also disclosed. The compounds disclosed are useful, inter alia, as anta...	02/08/2011
7829576	Beloxepin and analogs for the treatment of pain This present disclosure provides methods of treating pain with beloxepin and/or beloxepin analogs. ...	11/09/2010
7820827	Substituted piperidine compounds and methods of their use Novel 3,4-disubstituted-4-aryl-piperidine compounds are disclosed. Pharmaceutical compositions containing the 3,4-disubstituted-4-aryl-piperidine compounds and methods of their pharmaceutical uses are also disclosed. The compounds disclosed are useful, inter alia, a...	10/26/2010
7767814	Substituted piperidine compounds and methods of their use Certain 4-aryl-piperidine compounds, including N-substituted 9β-substituted-5-(3-substituted-phenyl)morphans and N-substituted octahydro-4a-(3-hydroxyphenyl)-10a-methyl-benzo[g]isoquinolines, pharmaceutical compositions, and methods of their use, inter alia, as opi...	08/03/2010
7700626	Compositions containing opioid antagonists Compositions containing opioid antagonists, particularly alvimopan and its active metabolite, with improved solubility and bioavailability for oral or parenteral administration, injectable dosage formulations, kits, and methods of making and using same are disclosed...	04/20/2010
7696220	Methods for the treatment or inhibition of ileus Methods for the treatment of ileus are disclosed wherein the peripheral mu opioid antagonist methylnaltrexone is administered. ...	04/13/2010
7671052	Phenyl derivatives and methods of use Novel phenyl compounds, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the compounds are agonists and/or ligands of cannabinoid receptors and may be useful, inter alia, for trea...	03/02/2010
7638527	Spirocyclic heterocyclic derivatives and methods of their use Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the δ opioid receptor and may be us...	12/29/2009
7598261	Spirocyclic heterocyclic derivatives and methods of their use Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the δ opioid receptor and may be us...	10/06/2009
7576207	Spirocyclic heterocyclic derivatives and methods of their use Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the δ-opioid receptor and may be us...	08/18/2009
7563802	Spirocyclic heterocyclic derivatives and methods of their use Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the δ opioid receptor and may be us...	07/21/2009
7544676	Sulfamoyl benzamides and methods of their use Novel sulfamoyl benzamide compounds, pharmaceutical compositions containing the sulfamoyl benzamide compounds, and methods of their pharmaceutical use are disclosed. In certain embodiments, the sulfamoyl benzamide compounds are agonists and/or ligands of cannabinoid...	06/09/2009
7538110	Opioid antagonists Certain quinolizidine and octahydropyridopyrazine compounds, pharmaceutical compositions, and methods of their use, inter alia, as opioid receptor antagonists are disclosed. ...	05/26/2009
7381721	Substituted piperidine compounds 3,4-Disubstituted-4-aryl-piperidine compounds are disclosed. Pharmaceutical compositions containing the 3,4-disubstituted-4-aryl-piperidine compounds and methods of their pharmaceutical uses are also disclosed. The compounds disclosed are useful, inter alia, as anta...	06/03/2008
7338962	Spirocyclic heterocyclic derivatives and methods of their use Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the δ opioid receptor and may be us...	03/04/2008
7297796	Sulfamoyl benzamide derivatives and methods of their use Novel sulfamoyl benzamide compounds, pharmaceutical compositions containing the sulfamoyl benzamide compounds, and methods of their pharmaceutical use are disclosed. In certain embodiments, the sulfamoyl benzamide compounds are agonists and/or modulating ligands of ...	11/20/2007
7294647	Kappa agonist compounds and pharmaceutical formulations thereof Compounds having kappa opioid agonist activity, compositions containing them and 5 method of using them as analgesics and pruritic agents are provided. The compounds of formulae I, II, III and IV have the structure: ...	11/13/2007
7160902	Amide derivatives and methods of their use Amide derivatives of the general formulae Ia and Ib: are disclosed. Pharmaceutical compositions containing these compounds, and methods for their use, inter alia, for treating and/or preventing gastrointestinal d...	01/09/2007
7091354	Processes for the preparation of peripheral opioid antagonist compounds and intermediates thereto Novel processes for the preparation of peripheral opioid antagonist compounds and intermediates thereto. The compounds prepared by the present processes may be useful, for example, as antagonists to the mu, kappa and delta opioid receptors, and thereby may be useful...	08/15/2006
7087749	Substituted piperidine compounds and methods of their use Certain 4-aryl-piperidine compounds, including N-substituted 9β-substituted-5-(3-substituted-phenyl)morphans and N-substituted octahydro-4a-(3-hydroxyphenyl)-10a-methyl-benzo[g]isoquinolines, pharmaceutical compositions, and methods of their use, inter alia, as opi...	08/08/2006
7034051	Fused bicyclic carboxamide derivatives and methods of their use Fused bicyclic carboxamide derivatives are disclosed. Pharmaceutical compositions containing the compounds and methods for their use are also disclosed. ...	04/25/2006
6992090	Substituted piperidine compounds and methods of their use Novel 3,4-disubstituted-4-aryl-piperidine compounds are disclosed. Pharmaceutical compositions containing the 3,4-disubstituted-4-aryl-piperidine compounds and methods of their pharmaceutical uses are also disclosed. The compounds disclosed are useful, inter alia, a...	01/31/2006
6992193	Sulfonylamino phenylacetamide derivatives and methods of their use Sulfonylamino phenylacetamide derivatives of the general formula are disclosed. Pharmaceutical compositions containing the compounds and methods for their use are also disclosed. In certain embodiments, the compounds o...	01/31/2006
6960612	Kappa agonist compounds, pharmaceutical formulations and method of prevention and treatment of pruritus therewith Methods for prevention or treatment of pruritus are provided. The methods comprise administering to a patient an effective amount of a kappa opioid receptor agonist compound. The involved kappa opioid receptor agonist compounds are of the type represented by the fol...	11/01/2005
6852713	Lactam derivatives and methods of their use Lactam derivatives of the general formula are disclosed. Pharmaceutical compositions containing the compounds and methods for their use are also disclosed. ...	02/08/2005
6794510	Processes for the preparation of peripheral opioid antagonist compounds and intermediates thereto Novel processes for the preparation of peripheral opioid antagonist compounds and intermediates thereto. The compounds prepared by the present processes may be useful, for example, as antagonists to the mu, kappa and delta opioid receptors, and thereby may be useful...	09/21/2004
6750216	Kappa agonist compounds and pharmaceutical formulations thereof Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided. The compounds of formula IIIB have the structure: wherein R1, R2	06/15/2004
6630462	Delta agonist analgesics Methods and pharmaceutical compositions for the treatment of pain, preferably with lowered risk of induction of seizure in a patient. The compositions contain active compounds that are tricyclic δ opioid receptor agonists of the general formula (I): ...	10/07/2003
6492351	Kappa agonist compounds, pharmaceutical formulations and method of prevention and treatment of pruritus therewith The compounds of formulae IIA, the structure: ##STR1## wherein R1, R2, and X4, X5, n are as described in the specification....	12/10/2002
6486165	Kappa agonist compounds, pharmaceutical formulations and method of prevention and treatment of pruritus therewith Method for the prevention or treatment of pruritus with anti-pruritic compounds is provided. The compounds of formula I ##STR1##...	11/26/2002
6476063	Kappa agonist compounds, pharmaceutical formulations and method of prevention and treatment of pruritus therewith Method for the prevention or treatment of pruritus with anti-pruritic compounds is provided. The compounds of formulae I, II, IIA, III, IIIA, IV and IVA have the structure: ##STR1## ##STR2## wherein R1, R2, R3, R...	11/05/2002
6469030	Methods for the treatment and prevention of ileus Methods for the treatment and/or prevention of ileus are disclosed. The methods comprise administering to a patient an effective amount of a peripheral mu opioid antagonist compound. Preferred compounds for use in the methods include piperidine-N-alkylcar...	10/22/2002
6451806	Methods and compositions involving opioids and antagonists thereof Novel methods and compositions comprising opioids and opioid antagonists. In preferred embodiments, the methods and compositions comprise opioids and peripheral mu opioid antagonist compounds. The methods and compositions are particularly suitable for tre...	09/17/2002
6391910	Kappa agonist compounds and pharmaceutical formulations thereof Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided. The compounds of formulae I, II, IIA, III, IIIA, IV and IVA have the structure: ##STR1## wherein R1, R2...	05/21/2002
6239154	Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith Method for the prevention or treatment of pruritis by administering to a patient an antipruritic compound, or pharmaceutically acceptable salt thereof, of the class arylacetamide, which is exemplified by compounds of the formulae I, II, IIA, III, IV and I...	05/29/2001

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Assignee: Adolor Corporation