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Assignee: Adolor Corporation


Location: Malvern, PA
No. of patents: 24

NumberTitleIssue Date
6573282Peripherally active anti-hyperalgesic opiates
Compositions and methods using the compositions for treatment of peripheral hyperalgesia are provided. The compositions contain an anti-hyperalgesia effective amount of one or more compounds that directly or indirectly interact with peripheral opiate rece...
06/03/2003
6353004Peripherally acting anti-pruritic opiates
Anti-pruritic compositions and methods of using the compositions for the prevention or treatment of pruritus comprising: ##STR1## wherein: R, R2, R3, R4, R7, Ar1 and Ar2 are as defined in t...
03/05/2002
6303611Kappa agonist compounds and pharmaceutical formulations thereof
Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided. The compounds of formula having the structure: ##STR1## wherein R1, R2, and X Y, Z, Ar and n are as describe...
10/16/2001
6190691Methods for treating inflammatory conditions
The present invention provides a number of screening methods for evaluating compounds capable of suppressing cytokine production either in vitro or in vivo. The methods generally involve stimulating the production of a cytokine in a cell, exposing a porti...
02/20/2001
6180623Kappa agonist compounds, pharmaceutical formulations and method of prevention and treatment of pruritus therewith
Compounds having kappa opioid agonist activity, compositions containing them and methods of using them as analgesics and anti-pruritic agents are provided. The compounds of formula IV have the structure: ##STR1## wherein X9 ; R1, R
01/30/2001
6057323Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics and anti-pruritic agents are provided. The compound of formula I, having the structure: ##STR1## wherein R1, R2 ...
05/02/2000
6054445Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritis therewith
Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics and anti-pruritic agents are provided. The compound of formulae IIA, having the structure: ##STR1## wherein R1, R2
04/25/2000
6048860Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
Anti-pruritic pharmaceutical formulations containing kappa agonist compounds and methods of prevention or treatment of pruritus in a mammal with the anti-pruritic formulations....
04/11/2000
6028063Kappa agonist compounds, pharmaceutical formulations and method of prevention and treatment of pruritus therewith
Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics and anti-pruritic agents are provided. The compounds of formula III having the structure: ##STR1## wherein Ar and X7 ; R
02/22/2000
6004964Kappa agonist anti-pruritic pharmaceutical formulaitons and method of treating pruritus therewith
Anti-pruritic pharmaceutical formulations containing kappa agonist compounds and methods of prevention or treatment of pruritus in a mammal with the anti-pruritic formulations....
12/21/1999
5981513Kappa agonist compounds, pharmaceutical formulations and method of prevention and treatment of pruritus therewith
Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics and anti-pruritic agents are provided. The compounds of formula II having the structure: ##STR1## wherein X4, X5...
11/09/1999
5962477Screening methods for cytokine inhibitors
The present invention provides a number of screening methods for evaluatiing compounds capable of suppressing cytokine production either in vitro or in vivo. The methods generally involve stimulating the production of a cytokine in a cell, exposing a port...
10/05/1999
5945443Kappa agonist compounds and pharmaceutical formulations thereof
Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided. The compound of formulae IV having the structure: ##STR1## wherein X9 ; R1, R2, R3...
08/31/1999
5888494Film-forming compositions of antihyperalgesic opiates and method of treating hyperalgesic and pruritic conditions therewith
Topical film-forming compositions for the prevention and treatment of prutitus containing an opiate that is substantially devoid of central nervous system effects....
03/30/1999
5869521Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
Anti-pruritic pharmaceutical formulations containing kappa agonist compounds and methods of prevention or treatment of pruritus in a mammal with the anti-pruritic formulations....
02/09/1999
5849762Peripherally acting anti-pruritic opiates
Anti-pruritic compositions and methods of using the compositions for the prevention or treatment of pruritus comprising: ##STR1## wherein M is ##STR2## wherein: R, R2, R3, R4, R7, Ar1 and Ar...
12/15/1998
5811078Spray formulations of antihyperalgesic opiates and method of treating topical hyperalgesic conditions therewith
Spray formulations of anti-hyperalgesic opiates having a peripheral selectivity of 251 to 1,280 in a solvent mixture of up to 15% w/w alcohol selected from the group consisting of ethyl propyl and isopropyl alcohol and water greater than or equal to 85% w...
09/22/1998
5798093Spray formulations of antihyperalgesic opiates and method of treating topical hyperalgesic conditions and pruritus therewith
Spray formulations of anti-pruritic opiates having a peripheral selectivity of 251 to 1,280 in a solvent mixture of up to 15% w/w alcohol selected from the group consisting of ethyl, propyl and isopropyl alcohol and water greater than or equal to 85% w/w ...
08/25/1998
5763445Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics and anti-pruritic agents are provided. The compounds of formular I, II, III and IV have the structure: ##STR1## wherein X, X4
06/09/1998
5760023Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
Anti-pruritic pharmaceutical formulations containing kappa agonist compounds and methods of prevention or treatment of pruritus in a mammal with the anti-pruritic formulations....
06/02/1998
5744458Kappa agonist compounds and pharmaceutical formulations thereof
Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided. The compound of formula II has the structure: ##STR1## wherein X4, X5 ; R1, R2 ; ...
04/28/1998
5688955Kappa agonist compounds and pharmaceutical formulations thereof
Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided. The compounds of formulae I, II, III and IV have the structure: ##STR1## wherein X, X4, X5, X7
11/18/1997
5667773Film-forming compositions of antihyperalgesic opiates and method of treating hyperalgesic conditions therewith
Topical anti-hyperalgesic film-forming compositions and methods of using compositions for the treatment of peripheral hyperalgesia comprising: a) a compound of the formula ##STR1## wherein M is ##STR2## wherein: R, R2, R3...
09/16/1997
5646151Kappa agonist compounds and pharmaceutical formulations thereof
Compounds, compositions and method of treating hyperalgesia comprising a compound of formula I, II, III and IV as defined in the specification....
07/08/1997
 
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