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| Number | Title | Issue Date |
| 7052719 | Matrices formed of polymer and hydrophobic compounds for use in drug delivery A lipid or other hydrophobic or amphiphilic compound (collectively referred to herein as “hydrophobic compounds”) is integrated into a polymeric matrix for drug delivery to alter drug release kinetics. In embodiments where the drug is water soluble, the drug is ... | 05/30/2006 |
| 6932983 | Porous drug matrices and methods of manufacture thereof Drugs, especially low aqueous solubility drugs, are provided in a porous matrix form, preferably microparticles, which enhances dissolution of the drug in aqueous media. The drug matrices preferably are made using a process that includes (i) dissolving a drug, prefe... | 08/23/2005 |
| 6730322 | Matrices formed of polymer and hydrophobic compounds for use in drug delivery A lipid or other hydrophobic or amphiphilic compound (collectively referred to herein as “hydrophobic compounds”) is integrated into a polymeric matrix for drug delivery to alter drug release kinetics. In embodiments where the drug is water soluble, the drug is ... | 05/04/2004 |
| 6689390 | Matrices formed of polymer and hydrophobic compounds for use in drug delivery A lipid or other hydrophobic or amphiphilic compound (collectively referred to herein as "hydrophobic compounds") is integrated into a polymeric matrix for drug delivery to alter drug release kinetics. In embodiments where the drug is water soluble, the d... | 02/10/2004 |
| 6645528 | Porous drug matrices and methods of manufacture thereof Drugs, especially low aqueous solubility drugs, are provided in a porous matrix form, preferably microparticles, which enhances dissolution of the drug in aqueous media. The drug matrices preferably are made using a process that includes (i) dissolving a ... | 11/11/2003 |
| 6610317 | Porous paclitaxel matrices and methods of manufacture thereof Paclitaxel is provided in a porous matrix form, which allows the drug to be formulated without Cremophor and administered as a bolus. The paclitaxel matrices preferably are made using a process that includes (i) dissolving paclitaxel in a volatile solvent... | 08/26/2003 |
| 6589557 | Porous celecoxib matrices and methods of manufacture thereof Celecoxib is provided in a porous matrix form wherein the dissolution rate of the drug is enhanced when the matrix is contacted with an aqueous medium. The porous matrix yields upon contact with an aqueous medium nanoparticles and microparticles of celeco... | 07/08/2003 |
| 6560897 | Spray drying apparatus and methods of use Improved spray drying apparati, and methods of use thereof, have been developed. The spray drying equipment includes a primary drying chamber and a secondary drying apparatus which includes tubing having a length sufficient to increase the contact time be... | 05/13/2003 |
| 6423345 | Matrices formed of polymer and hydrophobic compounds for use in drug delivery A lipid or other hydrophobic or amphiphilic compound (collectively referred to herein as "hydrophobic compounds") is integrated into a polymeric matrix for drug delivery to alter drug release kinetics. In embodiments where the drug is water soluble, the d... | 07/23/2002 |
| 6395300 | Porous drug matrices and methods of manufacture thereof Drugs, especially low aqueous solubility drugs, are provided in a porous matrix form, preferably microparticles, which enhances dissolution of the drug in aqueous media. The drug matrices preferably are made using a process that includes (i) dissolving a ... | 05/28/2002 |
| 6308434 | Spray drying method Improved spray drying methods of have been developed. The spray drying method includes use of a primary drying chamber and a secondary drying apparatus which includes tubing having a length sufficient to increase the contact time between the drying gas an... | 10/30/2001 |
| 6223455 | Spray drying apparatus and methods of use Improved spray drying apparati, and methods of use thereof, have been developed. The spray drying equipment includes a primary drying chamber and a secondary drying apparatus which includes tubing having a length sufficient to increase the contact time be... | 05/01/2001 |
| 6132699 | Microencapsulated fluorinated gases for use as imaging agents It has been discovered that the incorporation of fluorinated gases, especially a perfluorocarbon such as octafluoropropane, into synthetic polymeric microparticles, significantly enhances echogenicity as compared with microparticles having air incorporate... | 10/17/2000 |
| 6045777 | Method for enhancing the echogenicity and decreasing the attenuation of microencapsulated gases It has been discovered microparticles formed from natural or synthetic polymer with thicker walls have significantly enhanced echogenicity as compared with microparticles having thinner walls. The effect of wall thickness has been determined experimentall... | 04/04/2000 |
| 5837221 | Polymer-lipid microencapsulated gases for use as imaging agents It has been discovered that the incorporation of gases, especially fluorinated gases such as perfluorocarbons, into microparticles formed from the combination of a natural or synthetic polymer and lipid have significantly enhanced echogenicity as compared... | 11/17/1998 |
| 5611344 | Microencapsulated fluorinated gases for use as imaging agents It has been discovered that the incorporation of fluorinated gases, especially a perfluorocarbon such as octafluoropropane, into synthetic polymeric microparticles, significantly enhances echogenicity as compared with microparticles having air incorporate... | 03/18/1997 |
