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| Number | Title | Issue Date |
| 7674906 | Tetracyclic immunomodulatory compounds The present invention relates to novel heterocyclic compounds, to methods for their preparation, to compositions containing them, and to methods and use for clinical treatment of medical conditions which may benefit from immunomodulation, including rheumatoid arthri... | 03/09/2010 |
| 7615225 | Methods for treating a subject having cancer by the administration of a conjugate between a variant staphylococcal entertoxin E superantigen and an antibody that binds to the 5T4 antigen The present invention relates to compositions and methods of use, wherein the composition comprises a conjugate of a bacterial superantigen and an antibody moiety. More particularly, the bacterial superantigen has been modified to decrease seroreactivity with retain... | 11/10/2009 |
| 7589208 | Compositions containing quinoline compounds A stable solid pharmaceutical composition consisting essentially of an effective amount of a salt of formula (II) together with an alkaline-reacting component maintaining the pH preferably above 8, ... | 09/15/2009 |
| 7553849 | Compounds A compound of formula (I) wherein R is methyl, ethyl, n-propyl, iso-propyl, n-butyl or allyl; R′ is hydrogen, C1-C4 alkyl, C1-C3 alkoxy; halogen, trifl... | 06/30/2009 |
| 7511143 | Compositions containing quinoline compounds A stable solid pharmaceutical composition consisting essentially of an effective amount of a salt of formula (II) together with an alkaline-reacting component maintaining the pH preferably above 8, ... | 03/31/2009 |
| 7425623 | Antibody with specificity for colon cancer A binding structure which binds in, and/or to the surface of, tumour cells; a target structure displayed and/or expressed in, or on the surface of, tumour cells; a binding structure that recognises and blocks said target structure; a substance that binds to or block... | 09/16/2008 |
| 7339059 | Benzofurans and indols Compounds of formula (I) wherein X is a fluorine or a chlorine atom; the methyl groups located at the 2- and 5-position of the piperazine ring are in trans-configuration to each other; | 03/04/2008 |
| 7291612 | Immunomodulatory compounds The present invention relates to novel heterocyclic compounds, to methods for their preparation, to compositions containing them, and to methods and use for clinical treatment of medical conditions which may benefit from immunomodulation, including rheumatoid arthri... | 11/06/2007 |
| 7226601 | Conjugate between a modified superantigen and a target-seeking compound and the use of the conjugate A method for the treatment of a disease in a mammal by administering a therapeutically effective amount of a conjugate comprising a biospecific affinity counterpart and a peptide, wherein the peptide contains an amino acid sequence that is derived from staphylococca... | 06/05/2007 |
| 7226595 | Modified Chimeric superantigens and their use A conjugate between a target-seeking moiety and a modified superantigen, characterized in that the superantigen is a wild-type superantigen (SA I) in which an amino acid residue in a superantigen region (region I) determining binding to TCR, preferably TCRVβ, and T... | 06/05/2007 |
| 7189816 | Compounds An antibody, or a derivate or a fragment thereof, having a binding structure for a target structure is described. The antibody is displayed in, and on the cell surface of, human gastrointestinal epithelial tumour cells and in a subpopulation of normal human gastroin... | 03/13/2007 |
| 7125554 | Engineered superantigen for human therapy The present invention relates to compositions and methods of use, wherein the composition comprises a conjugate of a bacterial superantigen and an antibody moiety. More particularly, the bacterial superantigen has been modified to decrease seroreactivity with retain... | 10/24/2006 |
| 7081456 | Immunomodulatory compounds The present invention relates to novel heterocyclic compounds, to methods for their preparation, to compositions containing them, and to methods and use for clinical treatment of medical conditions which may benefit from immunomodulation, including rheumatoid arthri... | 07/25/2006 |
| 7074831 | Compounds, methods for their preparation and use thereof Compounds of formula (I) for clinical treatment of autoimmune diseases, inflammatory diseases, organ transplant rejection and malignant neoplasia. A pharmaceutical composition comprising a compound of formula (I)... | 07/11/2006 |
| 6962694 | Cytolysis of target cells by superantigen conjugates inducing T-cell activation A method for inactivating target cells in the presence of T cells by bringing the two types of cells in contact with a superantigen (SAG) in the presence of an immune modulator, characterized in that at least one of the superantigen and the immune modulator is in th... | 11/08/2005 |
| 6875869 | Process for the manufacture of quinoline derivatives A process for the preparation of the compounds of general formula (I) wherein R is selected from methyl, ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl, sec.-butyl and allyl; R5 is selected from the methyl,... | 04/05/2005 |
| 6727062 | Identification of target structures E.G. in vivo selection method for a phage library The invention relates to a selection method and the products identified using the selection method which includes the steps of identifying one or more binding structures to a target structure using one or more libraries. The method includes the steps of reacting a f... | 04/27/2004 |
| 6642249 | Immunomodulating compounds The present invention relates to a novel heterocyclic compound, a pharmaceutical composition comprisining said compound, a method and use of said compound for clinical treatment of medical conditions which may benefit from immunomodulation, e.g. rheumatoi... | 11/04/2003 |
| 6605616 | Quinoline derivatives The invention is related to compounds of general formula (I) ##STR1## wherein R is methyl, ethyl, n-propyl, iso-propyl, n-butyl or allyl; R' is methyl, methoxy, fluoro, chloro, bromo, azido, trifluorometlhyl, or OCHx Fy, wherein x=0-... | 08/12/2003 |
| 6593343 | Quinoline derivatives Compounds of formula (I) ##STR1## and tautomers thereof are effective for the treatment of mammals suffering from diseases resulting from autoimmunity and pathological inflammation.... | 07/15/2003 |
| 6518312 | Immune enhancement A method for stimulation of transcription factor AP (activator protein)-1 by administering a compound of the formula (I) ##STR1## wherein R is selected from methyl, ethyl, n-propyl, iso-propyl, c-propyl, n-butyl, sec.-butyl, iso-butyl, tert.-butyl, c-buty... | 02/11/2003 |
| 6395750 | Drugs for the treatment of malignant tumors The invention relates to a method for the treatment of tumors in mammals by the administration of compounds of the general formula (I) ##STR1## wherein A is O41 or NR42 R43 wherein R41 is hydrogen or a pharmaceu... | 05/28/2002 |
| 6133285 | Quinoline derivatives The invention is related to compounds of general formula (I) wherein R is methyl, ethyl, n-propyl, iso-propyl, n-butyl or allyl; R' is methyl, methoxy, fluoro, chloro, bromo, trifluoromethyl, or OCHx Fy, wherein x=0-2, y=1-3 with the... | 10/17/2000 |
| 6121287 | Quinoline derivatives The invention is related to compounds of general formula (I) ##STR1## wherein R is Me, Et, n-Pr, iso-Pr, n-Bu, iso-Bu, sec.-Bu or allyl; R' is hydrogen, Me, MeO, fluoro, chloro, brorno, CF3, or OCHx Fy ; R" is hydroge... | 09/19/2000 |
| 6077851 | Quinoline derivatives The invention relates to compounds of general formula (I) ##STR1## wherein R is selected from ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl, sec.-butyl and allyl; R4 is selected from hydrogen and pharmaceutically acceptable inorganic and... | 06/20/2000 |
