Assignee: Academia Sinica

Location: Taipei, TW
No. of patents: 189

Number	Title	Issue Date
8183393	Dye compound and dye-sensitized solar cell A dye compound is described, which is expressed by formula (I): wherein A1, A2 and A3 each independently represent a substituted or unsubstituted 1,4-phenylene or 2,5-thiophene group, and B	05/22/2012
8168413	Luminescent diamond particles A method for preparing luminescent diamond particles (e.g., fluorescent nanodiamonds). The method includes irradiating diamond particles with an ion beam and heating the irradiated diamond particles in a non-oxidizing atmosphere at a temperature between 600 and 1000...	05/01/2012
8158367	Cancer diagnosis based on levels of antibodies against Globo H and its fragments A cancer diagnostic method using a glycan array that contains Gb5 and Globo H, Bb2, Bb3, and/or Bb4. ...	04/17/2012
8153964	Ultrasound ionization mass spectrometer Methods and systems for ultrasound ionization mass spectrometry are provided. Analytes in a sample are ionized by subjecting them to ultrasound, facilitating their analysis by mass spectrometry. With these methods and systems, soft ionization of large analytes, incl...	04/10/2012
8147880	Polyacetylenic compounds for stimulating insulin gene exression, production and secretion This invention relates to a method of treating type II diabetes with a polyacetylenic compound of the following formula: in which R1 is H, C1-C10 alkyl, C2	04/03/2012
8142999	HLA alleles associated with adverse drug reactions and methods for detecting such This invention relates to a method of determining the presence of certain HLA alleles, such as HLA-B1502 or HLA-B5801, and a kit for carrying out this method. Also disclosed is a method for assessing whether a patient is at risk for developing adverse drug reactio...	03/27/2012
8138472	Molecular ion accelerator A novel system and methods for accelerating analytes including, without limitation, molecular ions, biomolecules, polymers, nano- and microparticles, is provided. The invention can be useful for increasing detection sensitivity in applications such as mass spectrome...	03/20/2012
8137666	Nattokinase for degrading and reducing amyloid fibrils—associated with alzheimer's disease, prion diseases and other amyloidoses A method of dissolving or disrupting pre-formed or pre-deposited amyloid fibrils and/or inhibiting amyloid formation, deposition, accumulation, or persistence in Alzheimer's disease, prion diseases and/or other amyloidoses in a mammalian subject is disclosed. In the...	03/20/2012
8129357	Method of making and using an adenosine analogue This document describes compounds, extracts, and pharmaceutical compositions relating to Gastrodia spp., and methods for the treatment subjects having metabolic disorders or medical conditions such as Huntington's disease, a trinucleotide repeat disease or ab...	03/06/2012
8129140	Thermophilic endo-glucanase and uses thereof A novel thermophilic endo-glucanase, nucleic acid encoding the endo-glucase, and uses thereof in converting ligocellulosic material to fermentable sugars. ...	03/06/2012
8114443	Phytase-expressing transgenic plants Disclosed are a transgenic plant and a transformed plant cell containing a heterologous nucleic acid that includes a sweet potato sporamin SPO promoter operably linked to a sequence encoding a polypeptide. Also disclosed are uses of the plant or cell. ...	02/14/2012
8105827	Protein expression systems Disclosed are recombinant non-insect host cells and use of activation of CMV or SV40 promoters by IE1, IE2 and the enhancer hr of the baculovirus in non-insect host cells for expression heterologous RNAs or polypeptides. Also disclosed are methods of using the cells...	01/31/2012
8093069	Functionalized nitride nanomaterials for electrochemistry and biosensor applications This invention refers to surface modification/functionalization of Nitride nanomaterials and electrochemistry and optical measurement based upon such functionalized Nitride materials. With this invention a variety of bio-molecules such as DNA, protein, and antigens ...	01/10/2012
8088887	Peptide-conjugates that bind to VEGF-stimulated or tumor vasculature and methods of treatment The invention provides nucleic acids, peptides, and antibodies for use in applications including diagnosis and therapy. The peptides target neovasculature and were identified by in vivo phage display. One such peptide, SP5-52, recognized the neovasculature of multip...	01/03/2012
8071105	Reishi F3 sub fraction polysaccharides and methods of using same The present disclosure relates to the discovery of methods of isolating subfractions of an F3 Reishi extract, and of administration of these novel isolates to eukaryotic cells in order to induce certain immumodulatory, hematopoeitic and tumor-inhibiting phenotypic c...	12/06/2011
8053769	Organic transistor inverter A transistor includes a first semiconductor layer associated with a first electrode; a second semiconductor layer associated with a second electrode; and a discontinuous layer between the first and second semiconductor layer. The discontinuous layer has a plurality ...	11/08/2011
8048860	Butanol extract of A method of treating a Th1-mediated disorder includes administering to a subject in need of the treatment an effective amount of a compound of the formula I: wherein R1 is H, alkyl, aryl, or cyclyl; R2	11/01/2011
8048455	Treatment of cancer and inflammatory disorder Disclosed are extracts, compositions, and methods for treating cancer and inflammatory disorders. Also disclosed are methods for preparing extracts or compounds for treating the disorders. ...	11/01/2011
8034992	Gibberellin 2-oxidase genes and uses thereof Novel gibberellin 2-oxidase (GA2ox) genes were identified. Differential expression of GA2ox genes correlated with flower development, seed germination, tiller growth and other developmental processes. In addition, the early and increased growth of tiller and adventi...	10/11/2011
8030029	Flu vaccines and methods of use thereof This disclosure is directed, inter alia, to polynucleotides, polypeptides, vectors, cells and compositions comprising the same, and their use in affecting viral pathogenesis, in particular for influenza viral infection. ...	10/04/2011
8024277	Reconstruction of gene networks and calculating joint probability density using time-series microarray, and a downhill simplex method Gene regulation network is reconstructed using time series microarray data under the method of the Bayesian network. Particular power-law function is used to calculate the joint probabilities among genes across time points. This invention discloses the use of the do...	09/20/2011
8019136	Optical sectioning microscopy Systems and methods for optical sectioning microscopy with structured illumination are provided. A light source generates a light beam with a spatial pattern for successively illuminating a sample at each phase of a plurality of phases. A detector detects a first se...	09/13/2011
8012686	Risk assessment for adverse drug reactions The present invention provides a method of predicting the risk of a patient for developing adverse drug reactions, particularly SJS or TEN. It was discovered that an HLA-B allele, HLA-B* 1502, is associated with SJS/TEN that is induced by a variety of drugs. The cor...	09/06/2011
7998482	Methods and reagents for the analysis and purification of polysaccharides The disclosure provides fusion proteins comprising a carbohydrate recognition domain of an innate immunity receptor and a heterologous polypeptide. The fusion proteins of the disclosure may be used, for example, to fingerprint polysaccharide compositions and to puri...	08/16/2011
7991454	Imaging of biological structures Images of blood vessels of a body are obtained by injecting a refraction enhancement contrast agent into the blood vessels to increase a difference in refractive indices of the blood vessels and surrounding material. The blood vessels are irradiated with a penetrati...	08/02/2011
7981639	Starch-derived products A method for producing a monosaccharide-rich syrup from starch-containing produce. The method includes treating a starch-containing produce slurry with a first starch hydrolyzing enzyme that hydrolyzes starch to oligosaccharide and a second starch hydrolyzing enzyme...	07/19/2011
7981428	Flu vaccines and methods of use thereof This disclosure is directed, inter alia, to polynucleotides, polypeptides, vectors, cells and compositions comprising the same, and their use in affecting viral pathogenesis, in particular for influenza viral infection. ...	07/19/2011
7977666	Quantum dot infrared photodetector apparatus The present invention is disclosed that a device capable of normal incident detection of infrared light to efficiently convert infrared light into electric signals. The device includes a substrate, a first contact layer formed on the substrate, an active layer forme...	07/12/2011
7972878	Quantum dot memory A method of making a quantum dot memory cell, the quantum dot memory cell including an array of quantum dots disposed between a first electrode and a second electrode, includes obtaining values for a tunneling current through the quantum dot memory cell as a functio...	07/05/2011
7972645	Dioscorea extracts for enhancing immune system An extract from a tuber of a Dioscorea plant is disclosed. Also disclosed is a composition containing an extract from a tuber of a Dioscorea plant, as well as methods of using the extract and composition. ...	07/05/2011
7964351	Risk assessment for adverse drug reactions The present invention provides a method of predicting the risk of a patient for developing adverse drug reactions, particularly SJS or TEN. It was discovered that an HLA-B allele, HLA-B* 1502, is associated with SJS/TEN that is induced by a variety of drugs. The cor...	06/21/2011
7960139	Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells The present disclosure relates to a method for metabolic oligosaccharide engineering that incorporates derivatized alkyne-bearing sugar analogs as “tags” into cellular glycoconjugates. The disclosed method incorporates alkynyl derivatized Fuc and alkynyl derivat...	06/14/2011
7947283	Compositions and methods for treating psoriasis by (Reishi) polysaccharides A method for treating psoriasis by providing a pharmaceutical composition containing at least Ganoderma lucidum extract and administering a therapeutically effective amount of the composition to a patient in need thereof. Also disclosed is a method for treati...	05/24/2011
7943330	Tailored glycoproteomic methods for the sequencing, mapping and identification of cellular glycoproteins The present disclosure relates to tailored glycoproteomic methods, and more particularly to methods for the sequencing, mapping and identification of cellular glycoproteins using saccharide-selective bioorthogonal probes. A method is disclosed for saccharide-selecti...	05/17/2011
7943309	HLA alleles associated with adverse drug reactions and methods for detecting such This invention relates to a method of determining the presence of certain HLA alleles, such as HLA-B1502 or HLA-B5801, and a kit for carrying out this method. Also disclosed is a method for assessing whether a patient is at risk for developing adverse drug reactio...	05/17/2011
7943134	Compositions and methods for identifying response targets and treating flavivirus infection responses Cellular receptors are identified that induce plasma leakage and other negative effects when infected with flaviviruses, such as dengue virus or Japanese encephamyelitis virus. Using fusion proteins disclosed herein, the receptors to which a pathogen, such as flaviv...	05/17/2011
7928293	Rice glutelin gene promoters A nucleic acid containing a glutelin gene promoter. Disclosed are transformed plant cells and transgenic plants containing a nucleic acid that includes the promoter operably linked to a sequence encoding heterologous protein. Also disclosed are methods of making the...	04/19/2011
7928077	Alpha-galactosyl ceramide analogs and their use as immunotherapies The present disclosure relates to synthetic alpha-galactosyl ceramide (α-GalCer) analogs, and their use as immunotherapies. In one aspect. a method of activating a cytokine response in a subject includes administering an effective amount of a compound to a subject,...	04/19/2011
7927856	Thermophilic endo-glucanase and uses thereof A novel thermophilic endo-glucanase, nucleic acid encoding the endo-glucase, and uses thereof in converting lignocellulosic material to fermentable sugars. ...	04/19/2011
7927850	Composition containing trehalose synthase and methods of use thereof The present invention relates to the isolation and functional identification of a novel acid and heat resistant trehalose synthase enzyme cloned from Picrophilus torridus. More particularly, the present invention discloses the DNA sequence for the Picrophi...	04/19/2011

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Assignee: Academia Sinica