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| Number | Title | Issue Date |
| 5063235 | 4-[(diaryl)hydromethyl]-1-piperidinealkanols and esters and carbamates thereof useful in the treatment of allergic disorders Novel compounds of the formula: ##STR1## are disclosed wherein Ar and Ar1 are phenyl, sustituted phenyl or pyridinyl, "alk" is a C1 -C12 straight or branched hydrocarbon chain, and R is H, loweralkylcarbonyl, arylcarb... | 11/05/1991 |
| 5061720 | Substituted-4-thiazolidinone derivatives Disclosed are novel substituted 4-thiazolidinone derivatives having cyclooxygenase and 5-lipoxygenase inhibiting properties and which are topical antiinflammatory agents for inflammed conditions of the skin having the formula: ##STR1## wherein R... | 10/29/1991 |
| 4960896 | Process for the preparation of 5-chloro and 5-bromo-2-hydroxynicotinic acids A process for the preparation of 5-halo-2-hydroxynicotinic acids having the formula: ##STR1## wherein X is chlorine or bromine, Y and Z are selected from hydrogen, loweralkyl or loweralkyl, is described wherein a corresponding 2-hydroxynicotinic... | 10/02/1990 |
| 4960776 | 4-aryl-N-(alkylaminoalkyl, heterocyclicamino and heterocyclicamino)alkyl)-1-piperazinecarboxamides Novel 4-aryl-N-[2-(dialkylamino and heterocyclicamino)alkyl]-1-piperazinecarboxamides of the formula: ##STR1## wherein B is oxygen or sulfur; Ar is selected from ##STR2## or 2, 3 or 4-pyridyl; X is selected from hydrogen, halogen, loweralkyl, ... | 10/02/1990 |
| 4956359 | 3-aryloxy and 3-arylthioazetidinecarboxamides as anticonvulsants and antiepileptics Novel 3-aryloxy and 3-arylthioazetidinecarboxamides having utility in a method of treating convulsions and epilepsy and compositions therefor are disclosed having the formula: ##STR1## wherein Z is oxygen or sulfur; B is oxygen or sulfur; Ar is pyrid... | 09/11/1990 |
| 4898874 | Acetic acid derivatives of 3-aryl-2,1-benzisoxazole and esters and amides thereof 3-Aryl-2,1-benzisoxazole compounds having the formula: ##STR1## wherein R1 and R2 are hydrogen or methyl; R3 and R4 are hydroxyl, loweralkoxy, amino or --OM wherein M is a pharmaceutically acceptable cation; X i... | 02/06/1990 |
| 4808404 | Live vaccine for coccidiosis utilizing coccidial sporozoites Methods and compositions are disclosed for vaccinating warm-blooded animals against coccidiosis utilizing suspensions of excysted coccidial sporozoites in physiologically balanced medium containing water-soluble polymeric stabilizers selected from gels, g... | 02/28/1989 |
| 4772600 | Fused imidazoheterocyclic compounds and pharmaceutical compositions Imidazoheterocyclic compounds having the formula: ##STR1## wherein the A ring is pyridine in any of its four positions; B is carbonyl, thioxomethyl or hydroxymethylene; Z is hydrogen, halogen, loweralkyl, hydroxy, loweralkoxy, diloweralkylamino or ni... | 09/20/1988 |
| 4727152 | Intermediates useful in the preparation of fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof Chemical intermediates having the formula: ##STR1## wherein A represents an aromatic or heterocyclic ring system selected from benzene, a naphthalene, a quinoline or a pyridine in any of its four positions, any of the rings systems are optionally sub... | 02/23/1988 |
| 4717563 | 2-alkoxy-N-(1-azabicyclo(2.2.2)oct-3-yl) benzamides and thiobenzamides in a method for alleviating emesis caused by non-platinum anticancer drugs A method of controlling emesis caused by non-platinum anti-cancer drugs with 2-alkoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamides and thiobenzamides having the formula ##STR1## wherein X is oxygen or sulfur; R1 is loweralkyl; and R2 | 01/05/1988 |
| 4705853 | Fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof Aromatic azepinones and thiones having the formula ##STR1## wherein; A is benzene, naphthalene, quinoline or pyridine; B is oxygen or sulfur; E is oxygen, sulfur or ##STR2## n is 1, 2 or 3; Z is an amino or a heterocyclic nitrogen-containing rad... | 11/10/1987 |
| 4698430 | Nitro, amino and aroylamino-n-phenylpyridinamines Nitro, amino and aroylamino-N-phenylpyridinamines as chemical intermediates and/or having antidepressant activity having the formula ##STR1## wherein R3 is nitro, amino or aroylamino, and Q is hydrogen, --NR1 R2 or ha... | 10/06/1987 |
| 4610819 | Process for the preparation of aromatic-1,4-oxazepinones and thiones A process for the preparation of 1,4-oxazepinones and thiones having the formula: ##STR1## wherein A is an aromatic ring selected from benzene, naphthalene, quinoline or pyridine; n is 1 to 3; Z is an amino radical; R is hydrogen, loweralkyl, cy... | 09/09/1986 |
| 4609735 | Certain aryloxy-4-chloro-2-butanol intermediates Novel 1-aryloxy-4-amino-2-butanols of the formula wherein AR is 1-naphythyl, 2-naphthyl, indene-4(or 5-)yl, 3-(or 5-)chloro-2-pyridyl, phenyl, monosubstituted phenyl or di-substituted phenyl, R1 is lower alkyl, phenyl, phenylalkyl, 2-hydroxymet... | 09/02/1986 |
| 4605550 | Delayed release formulations and processes for making them There is disclosed a granular composition having particles of average particle size as determined by sieving in the range 70 to 500 microns, the said particles comprising up to 55% of active ingredient e.g. ferrous sulphate having primary particles the ma... | 08/12/1986 |
| 4605652 | Method of enhancing memory or correcting memory deficiency with arylamido (and arylthioamido)-azabicycloalkanes A pharmaceutical method for improving memory or correcting memory deficiency is disclosed, utilizing compounds having the formula: ##STR1## wherein n1, n2, n3, and n4 =0 to 3; R1, R2, ... | 08/12/1986 |
| 4604404 | Antiviral sulfonated naphthalene formaldehyde condensation polymers A method is disclosed for combating Herpes simplex viruses, Types I and II, which comprises topically applying and antiviral arylsulfonic acid polymer to the animal tissue under attack. Bacterial infections are also affectively treated.... | 08/05/1986 |
| 4594189 | Process for preparing 3-phenoxy-1-azetidines and carboxamide derivatives An improved process is disclosed for preparing 3-phenoxyazetidines which utilizes a phase transfer catalyst to add the phenoxy group to azetidine blocked in the 1-position by a diphenylmethane group and utilizes a stabilizing tertiary amine base to preven... | 06/10/1986 |
| 4592866 | Fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof Aromatic azepinones and thiones having the formula ##STR1## wherein; A is benzene, naphthalene, quinoline or pyridine; B is oxygen or sulfur; E is oxygen, sulfur or ##STR2## n is 1, 2 or 3; Z is an amino or a heterocyclic nitrogen containing rad... | 06/03/1986 |
| 4593034 | 2-alkoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamides and thiobenzamides 2-Alkoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamides and thiobenzamides having the formula ##STR1## wherein X is oxygen or sulfur; R1 is loweralkyl; and R2 is selected from the group consisting of hydrogen, halo, 4,5-benzo, alkoxy... | 06/03/1986 |
| 4593102 | N-[(amino)alkyl]-1-pyrrolidine, 1-piperidine and 1-homopiperidinecarboxamides (and thiocarboxamides) with sulfur linked substitution in the 2, 3 or 4-position Novel pyrrolidine, piperidine and homopiperidinecarboxamide and thiocarboxamide compounds having the formula: ##STR1## wherein X is --S--, --S(O)-- or --S(O)2 --; A is a loweralkalene chain and A1 and A2 are alkalene ... | 06/03/1986 |
| 4585785 | Cis and trans-3-aryloxy-4-hydroxypyrrolidines used as anti-arrhythmics Cis and trans-3-aryloxy-4-hydroxypyrrolidines and derivatives thereof having the formula: ##STR1## are disclosed wherein R1 is hydrogen, loweralkyl, benzyloxycarbonyl and N-loweralkylcarbamoyl; R2 is hydrogen, lower alkyl, cyclo... | 04/29/1986 |
| 4538001 | 1-Aryloxy-4-amino-2-butanols Novel 1-aryloxy-4-amino-2-butanols of the formula wherein Ar is 1-naphthyl, 2-naphthyl, indene-4(or 5-)yl, 3-(or 5-)chloro-2-pyridyl, phenyl, monosubstituted phenyl or di-substituted phenyl, R1 is lower alkyl, phenyl, phenyl-alkyl, 2-hydroxymet... | 08/27/1985 |
| 4536386 | Method of controlling emesis caused by cisplatin in cancer chemotherapy High dosages of metoclopramide or a pharmaceutical salt thereof is administered intravenously to human cancer patients undergoing cisplatin chemotherapy to prevent emesis.... | 08/20/1985 |
| 4518603 | [2-[(Nitropyridinyl)amino]phenyl]arylmethanones in a process for preparing pyrido[1,4]benzodiazepines [2-[(Nitropyridinyl)amino]phenyl]arylmethanones as chemical intermediates and/or having antidepressant activity having the formula: ##STR1## wherein; B is carbonyl, thioxomethyl, ketal or thioketal, R is hydrogen or --alk1 -Q, Q is hydrogen, --... | 05/21/1985 |
| 4508724 | Aryloxymethylpyrrolidinols and piperidinols having antidepressant, antiarrhythmic or hypotensive activity Novel aryloxymethylpyrrolidinols and piperidinols are provided of the formula: ##STR1## wherein R1 is hydrogen, loweralkyl and phenylloweralkyl; R2 is hydrogen, loweralkyl and acyl; R3 is phenyl, naphthyl, 4-indanyl a... | 04/02/1985 |
| 4505907 | N-Formyl and N-hydroxymethyl-3-phenoxy-1-azetidinecarboxamides N-Formyl and N-hydroxymethyl-3-phenoxy-1-azetidinecarboxamides having the formula: ##STR1## wherein R is selected from formyl and hydroxymethyl and R1 is selected from hydrogen, fluoro, loweralkyl, loweralkoxy, trifluoromethyl, acetyl... | 03/19/1985 |
| 4480100 | [2-[(Nitropyridinyl)amino]phenyl]arymethanones [2-[(Nitropyridinyl)amino]phenyl]arylmethanones as chemical intermediates and/or having antidepressant activity having the formula: ##STR1## wherein: B is carbonyl, thioxomethyl, ketal or thioketal, R is hydrogen or -alk1 -Q, Q is hydrogen, --N... | 10/30/1984 |
| 4463190 | 1-Aryloxy-4-amino-2-butanols Novel 1-aryloxy-4-amino-2-butanols of the formula wherein Ar is 1-naphthyl, 2-naphthyl, indene-4(or 5-)yl, 3-(or 5-)chloro-2-pyridyl, phenyl, monosubstituted phenyl or di-substituted phenyl, R1 is lower alkyl, phenyl, phenylalkyl, 2-hydroxymeth... | 07/31/1984 |
| 4452809 | Trans-4-(2-chlorophenoxy)-1-ethyl-3-pyrrolidinol and anti-depressant use thereof Cis and trans-3-aryloxy-4-hydroxypyrrolidines and derivatives thereof having the formula: ##STR1## are disclosed wherein R1 is hydrogen, loweralkyl, benzyloxycarbonyl and N-loweralkylcarbamoyl; R2 is hydrogen, lower alkyl, cyclo... | 06/05/1984 |
| 4447361 | Aryl substituted pyrido[1,4]benzodiazepines Pyrido[1,4]benzodiazepines having antidepressant activity of the formula ##STR1## wherein Ar is 2, 3 and 4-pyridinyl, 2 or 3-thienyl, phenyl or a substituted phenyl; R is hydrogen, loweralkyl or an amine on the end of a hydrocarbon chain; Z is hydrog... | 05/08/1984 |
| 4440785 | Methods of using 2-aminobiphenylacetic acids, esters, and metal salts thereof to treat inflammation Novel 2-aminobiphenylacetic acids, esters and metal salts of the formula are disclosed: ##STR1## wherein R represents hydrogen, lower alkyl, sodium or potassium; R1 represents fluoro, chloro, bromo, lower-alkyl or amino; R2 repr... | 04/03/1984 |
| 4379167 | 1-Aryloxy-4-amino-2-butanols and the pharmaceutical use thereof Novel 1-aryloxy-4-amino-2-butanols of the formula wherein Ar is 1-naphthyl, 2-naphthyl, indene-4(or 5-)yl, 3-(or 5-)chloro-2-pyridyl, phenyl, monosubstituted phenyl or di-substituted phenyl, R1 is lower alkyl, phenyl, phenylalkyl, 2-hydroxymeth... | 04/05/1983 |
| 4379151 | 3-Phenoxyazetidines for anorexigenic activity 3-Phenoxyazetidines having the formula: ##STR1## wherein R is hydrogen, aminocarbonyl and trifluoromethyl having anorexigenic activity are disclosed.... | 04/05/1983 |
| 4377582 | 2-Phenyl-4-[cis-2,5-dimethyl-4-(2-pyridinyl)-1-piperazinyl]quinazoline Novel hypotensive agents are disclosed which are quinazolines substituted in the 2 and 4 position having the general formula: ##STR1## wherein Q is a secondary amine radical illustrated by loweralkanolylamino or a tertiary amine radical such as pyrro... | 03/22/1983 |
| 4362667 | Optical isomers of 4-amino-N-(1-cyclohexyl-3-pyrrolidinyl)-N-methylbenzamide The resolution of racemic 4-amino-N-(1-cyclohexyl-3-pyrrolidinyl)-N-methylbenzamide into the optically active (+) and (-) isomers is disclosed.... | 12/07/1982 |
| 4358599 | Synthesis of 4-amino-1,2-hydrocarbyl pyrazolidines via 4-nitro analogs 4-Nitro-1,2-hydrocarbyl pyrazolidines are prepared by a novel route from 1,2-disubstituted hydrazines and 1,3-di-(secondary amino)-2-nitropropanes and reduced to the corresponding 4-amino-1,2-hydrocarbyl pyrazolidines, which latter compounds are intermedi... | 11/09/1982 |
| 4356209 | Food coloring and flavoring agent from defatted wheat germ A process for converting defatted wheat germ to a brown cocoa-like flavoring agent for foods which can serve as a replacement of 50% or more cocoa or chocolate without deleterious effect on expectable flavor and color, but with cost reduction of better th... | 10/26/1982 |
| 4343804 | 4-Amino-3-quinolinecarboxylic acids and esters-antisecretory anti-ulcer compounds A method of reducing gastric acidity and treating peptic ulcers and pharmaceutical compositions therefor with certain 4-amino-3-quinolinecarboxylic acids and esters are disclosed. Illustrative of compounds useful in the method which relies on activity as ... | 08/10/1982 |
| 4333951 | 2-Amino-6-biphenylacetic acids Novel 2-amino-6-biphenylacetic acids, esters, and metal salts are provided of the formula: ##STR1## wherein R represents hydrogen or lower alkyl, R1 represents fluoro, chloro, bromo, lower-alkyl or amino; R2 represents lower-alk... | 06/08/1982 |
