Assignee: AMGEN, INC.

Location: Thousand Oaks, CA
No. of patents: 22

Number	Title	Issue Date
8183415	Methods of synthesizing cinacalcet and salts thereof Methods of preparing cinacalcet, cinacalcet derivatives, and salts thereof is disclosed herein. Also disclosed herein are polymorphs of cinacalcet, compositions of cinacalcet, and methods of treating a subject by administering cinacalcet, wherein cinacalcet is prepa...	05/22/2012
8101617	Disubstituted ureas and uses thereof in treating heart failure Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure. ...	01/24/2012
8080542	S1P receptor modulating compounds and use thereof The present invention relates to amides that have activity as SIP receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor activity. The compounds may be used as immunomodulators, e.g., for treating or pre...	12/20/2011
8080254	OB fusion protein compositions and methods The present invention relates to Fc-OB fusion protein compositions, methods of preparation of such compositions and uses thereof. In particular, the present invention relates to a genetic or chemical fusion protein comprising the Fc immunoglobulin region, derivative...	12/20/2011
8030457	Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9) Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 ...	10/04/2011
7964365	Methods for diagnosing and monitoring the progression of cancer Methods for measuring c-Met levels in urine and blood samples are provided. Methods for diagnosis and prognosis evaluation for cancer are also provided. ...	06/21/2011
7811566	Antibody-induced apoptosis Anti-Her2 antibodies which induce apoptosis in Her2 expressing cells are disclosed. The antibodies are used to “tag” Her2 overexpressing tumors for elimination by the host immune system. Also disclosed are hybridoma cell lines producing the antibodies, methods f...	10/12/2010
7795413	Nucleic acids encoding human anti-NGF neutralizing antibodies as selective NGF pathway inhibitors This invention provides antibodies that interact with or bind to human nerve growth factor (NGF) and neutralize the function of NGF thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing NGF function, and par...	09/14/2010
7737111	Peptides and related molecules that bind to TALL-1 The present invention concerns therapeutic agents that modulate the activity of TALL-1. In accordance with the present invention, modulators of TALL-1 may comprise an amino acid sequence Dz2Lz4 wherein z2 is an amino acid residue and...	06/15/2010
7728110	Antibodies to SARS coronavirus The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to human SARS-CoV S protein, and that function to neutralize SARS-CoV. The invention also relates to antibodies that are bispecific, de...	06/01/2010
7705130	Antibodies directed to HER-3 and uses thereof The present invention relates to binding proteins that bind to HER-3 and polynucleotides encoding the same. Expression vectors and host cells comprising the same for the production of the binding protein of the invention are also provided. In addition, the invention...	04/27/2010
7671180	Fibroblast growth factor-like polypeptides and variants thereof The present invention provides novel Fibroblast Growth Factor-like (FGF-like) fusion polypedtides. ...	03/02/2010
7667008	Fibroblast growth factor-like polypeptides and variants thereof The present invention provides novel Fibroblast Growth Factor-like (FGF-like) fusion polypeptides. ...	02/23/2010
7659276	Melanin concentrating hormone receptor antagonist Novel compounds, or pharmaceutically-acceptable salts, tautomers or prodrugs thereof, of Formula I wherein A, W, X, Z, R1-R3, and R8 are as defined in the specification, are provided. Also p...	02/09/2010
7632922	Osteoprotegerin The present invention discloses a novel secreted polypeptide, termed osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding osteoprotegerin,...	12/15/2009
7605289	Benzamide derivatives and uses related thereto Benzamide derivatives of formula I and II, and pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof, and pharmaceutical compositions comprising the same, are described and have therapeutic utility, particularly in the treatment of diabete...	10/20/2009
7601818	Human anti-NGF neutralizing antibodies as selective NGF pathway inhibitors This invention provides antibodies that interact with or bind to human nerve growth factor (NGF) and neutralize the function of NGF thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing NGF function, and par...	10/13/2009
7541438	Monoclonal antibody against connective tissue growth factor and medicinal uses thereof A human monoclonal antibody useful for the treatment of various diseases caused by human connective tissue growth factor (CTGF) and preventing the onset of the above diseases; medicinal uses thereof; and various monoclonal antibodies having various characteristics a...	06/02/2009
7528244	Regulators of apoptosis The invention provides methods and compositions relating to apoptosis regulating proteins, known as Casper proteins, and related nucleic acids. The proteins may be produced recombinantly from transformed host cells from the disclosed Casper encoding nucleic acid or ...	05/05/2009
7524940	OB protein compositions and methods The present invention provides methods and compositions for treating excess weight by administering OB protein in a form for constant supply, at a dosage of less than or equal to about 1 mg protein/kg body weight/day. Compositions and methods used for production of ...	04/28/2009
7514566	Thiazole compounds and methods of use The invention relates to thiazole compounds of Formula I and Formula II and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The ...	04/07/2009
7514438	Melanin concentrating hormone receptor antagonist Novel compounds, or pharmaceutically-acceptable salts, tautomers or prodrugs thereof, of Formula I wherein A, W, X, Z, R1-R3, and R8 are as defined in the specification, are provided. Also p...	04/07/2009

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Assignee: AMGEN, INC.