Celebrity Inventors
Mark Twain (Samuel L. Clemens) received Patent No. 121,992 for "An Improvement in Adjustable and Detachable Straps for Garments." He later received two more patents: one for a self-pasting scrapbook and one for a game to help players remember important historical dates.
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| Number | Title | Issue Date |
| 6024721 | Mixing system for an active agent delivery device The present invention is directed to a mixing system for an active agent delivery device. The device comprises an elongate tubular member having first and second ends and a mixing system. The mixing system enables the entire dose of active agent to be ent... | 02/15/2000 |
| 6020000 | Banded prolonged release active agent dosage form The present invention is directed to an active agent dosage form that is useful for the prolonged delivery of an active agent formulation to a fluid environment of use. The active agent dosage form is a matrix that has an insoluble material circumscribing... | 02/01/2000 |
| 6004578 | Permeation enhances for transdermal drug delivery compositions, devices and methods The present invention is directed to the transdermal administration of at least one drug together with a suitable amount of a permeation enhancer comprising monoalkyl ethers of polyethyleneglycol and their alkyl or aryl carboxylic acid esters and carboxym... | 12/21/1999 |
| 5993435 | Device and method of iontophoretic drug delivery A selectively permeable membrane (14) is positioned between the agent reservoir (15) and the electrode (11) of a donor electrode assembly (8) in an iontophoretic delivery device (10). Optionally, an electrolyte reservoir (13) is positioned intermediate th... | 11/30/1999 |
| 5990179 | Composition and method of enhancing electrotransport agent delivery A composition suitable for transdermal electrotransport delivery of an agent through a body surface comprises a free acid/base form of an agent to be delivered by transdermal electrotransport, and a salt form of the agent, and optionally a permeation enha... | 11/23/1999 |
| 5985324 | Flow controller configurations for an active agent delivery device The present invention is directed to an oral active agent delivery system comprising improved flow controllers. A hollow tubular member (10) containing the active agent formulation and having a fluid passing controller (14) is placed at one end (16) into ... | 11/16/1999 |
| 5978701 | Electrotransport device with separable controller and drug unit and method of setting controller output A two-part electrotransport drug delivery device (20) is comprised of a controller (22) which has a plurality of different electronic outputs. The controller (22) is adapted to be mechanically and electrically coupled to a plurality of different drug-cont... | 11/02/1999 |
| 5955103 | Dosage form comprising antiepileptic drug A dosage form is disclosed for delivering an antiepileptic drug, which dosage form comprises a laminated wall for maintaining the integrity of the dosage form and of the antiepileptic drug.... | 09/21/1999 |
| 5941844 | Method and device for controlling mammalian reproductive cycle A method encompasses the substantially continuous electrotransport delivery of luteinizing hormone releasing hormone (LHRH), prologues, analogues, salts or mixtures thereof, preferably at a substantially constant rate, to a female mammal for the purpose o... | 08/24/1999 |
| 5932547 | Non-aqueous polar aprotic peptide formulations This invention relates to stable non-aqueous polar aprotic formulations of peptide compounds. These stable formulations comprise peptide in non- aqueous polar aprotic solvent. They may be stored at elevated temperatures for long periods of time and are es... | 08/03/1999 |
| 5926794 | Visual rating system and method An improved performance appraisal system is disclosed which utilizes a visual scoring model which, utilizing visual simplicity, enables raters to capture complex, comparative, hierarchial performance information which is difficult to communicate in number... | 07/20/1999 |
| 5925015 | Nutritional support system A nutritional system is disclosed, for delivering a colorant dye to a nutritional fluid that flows through the nutritional system.... | 07/20/1999 |
| 5922353 | Interlocking couplings for osmotic delivery devices A delivery system is disclosed for delivering a fluid-sensitive active agent such as a somatotropin, or an analogue or derivative thereof, to an animal such as a bovine. The delivery system comprises a first wall section, a second wall section and a locki... | 07/13/1999 |
| 5919478 | Incorporating poly-N-vinyl amide in a transdermal system The present invention comprises a composition comprising a matrix adapted to be placed in drug-and permeation-enhancing mixture-transmitting relation to a selected skin or other body site. The matrix contains sufficient amounts of drug, permeation enhance... | 07/06/1999 |
| 5919155 | Electrotransport system having flexible connector means A device (10) for the electrically assisted delivery of a therapeutic agent is described. The device (10) has rigid zones or regions (12, 14) which are physically connected by a flexible means (16) such as a web. The flexible means (16) permits the rigid ... | 07/06/1999 |
| 5916582 | Aqueous formulations of peptides This invention relates to stable liquid aqueous formulations of peptide compounds at high concentrations. These stable formulations comprise at least about 10% peptide in water. They may be stored at elevated temperatures for long periods of time and are ... | 06/29/1999 |
| 5914131 | Hydromorphone therapy A hydromorphone composition, a hydromorphone dosage form and a method for administering hydromorphone are disclosed, indicated for the management of pain.... | 06/22/1999 |
| 5906832 | Method for treating epilepsies A dosage form is disclosed for delivering an antiepileptic drug, which dosage form comprises for maintaining the integrity of the dosage form and of the antiepileptic drug.... | 05/25/1999 |
| 5904935 | Peptide/protein suspending formulations The present invention provides improved compositions for improving the chemical and physical stability of peptides and proteins. The invention provides a liquid beneficial agent formulation containing a liquid suspension comprising at least 5% by weight b... | 05/18/1999 |
| 5900250 | Monoglyceride/lactate ester permeation enhancer for oxybutnin A composition of matter for application to a body surface or membrane to administer oxybutynin by permeation through the body surface or membrane, the composition comprising, in combination, the oxybutynin to be administered, in a therapeutically effectiv... | 05/04/1999 |
| 5897878 | Method for administering steroid A dosage form is disclosed comprising means for lessening the tackiness and/or irritation of the components of the dosage form to mucosal tissue. The dosage form provides means for forming in the dosage form a floc comprising a drug, which floc, when deli... | 04/27/1999 |
| 5883135 | Composition, device, and method for enhanced electrotransport agent delivery An electrotransport composition comprises at least one C2 -C4 lower alcohol, unsaturated derivatives thereof, or mixtures thereof, and at least one C8 -C14 higher alcohol, unsaturated derivatives thereof, or mix... | 03/16/1999 |
| 5879322 | Self-contained transdermal drug delivery device A method for manufacturing a transdermal drug delivery device (10) is disclosed wherein a component (32) and/or a subassembly (20) are intentionally adapted to be separable from the rest of the device for disposal which is more medically or environmentall... | 03/09/1999 |
| 5876750 | Effective therapy for epilepsies A dosage form is disclosed for delivering an antiepileptic drug, which dosage form comprises a laminated wall for maintaining the integrity of the dosage form and of the antiepileptic drug.... | 03/02/1999 |
| 5871770 | Implantable system for delivery of fluid-sensitive agents to animals A delivery system (10) is disclosed for delivering a fluid-sensitive beneficial agent (7) such as a somatotropin, or an analogue or derivative thereof, to an animal such as a bovine. The delivery system comprises a wall that surrounds an internal compartm... | 02/16/1999 |
| 5871460 | Electrotransport system with ion exchange material providing enhanced drug delivery An electrotransport apparatus using dispersed ion exchange material (19,93) is disclosed. The ion exchange material (19,93) may be dispersed in either the donor electrode assembly (10), the counter electrode assembly (10) or both electrode assemblies. The... | 02/16/1999 |
| 5866164 | Composition and dosage form comprising opioid antagonist A composition of matter is disclosed and claimed comprising an opioid antagonist and a high molecular weight poly(alkylene) or a poly(carboxymethylcellulose). A dosage form is disclosed and claimed comprising the composition of matter for displacing an op... | 02/02/1999 |
| 5866161 | Hydrocodone therapy A hydrocodone composition, a hydrocodone dosage form, and a method of administering hydrocodone are disclosed and indicated for hydrocodone therapy.... | 02/02/1999 |
| 5865792 | Reduction of skin irritation during electrotransport delivery The invention is directed to a composition and product for use in an electrotransport device. The composition includes an ionized drug, an anti-inflammatory agent and a solvent. Preferably, the anti-inflammatory agent is hydrocortisone or esters thereof, ... | 02/02/1999 |
| 5861166 | Delivery device providing beneficial agent stability This invention relates to fluid-imbibing delivery devices for delivering a beneficial agent to a biological environment of use. In particular, the devices include a rigid housing defining an internal compartment comprising a substantially impermeable firs... | 01/19/1999 |
| 5857992 | Device and method of iontophoretic drug delivery A selectively permeable membrane (14) is positioned between the agent reservoir (15) and the electrode (11) of a donor electrode assembly (8) in an iontophoretic delivery device (10). Optionally, an electrolyte reservoir (13) is positioned intermediate th... | 01/12/1999 |
| 5853383 | Preparation for formulations for electrotransport drug delivery A method is provided for preparing drug formulations suitable for electrotransport drug delivery. The drug to be delivered, present in salt form, is contacted with an ion exchange material prior to incorporation into the reservoir (26) of an electrotransp... | 12/29/1998 |
| 5842476 | Method for controlling fertility An osmotic device is disclosed comprising an exterior coat comprising an estrogenic and a progestogenic steroid that are delivered immediately as a contraceptive pair for fertility regulation in a female, and a compartment comprising an estrogenic steroid... | 12/01/1998 |
| 5843014 | Display for an electrotransport delivery device An electrotransport delivery device (10) with a display (14) having only on and off states, and a method of operating the display (14), are provided. Preferably, the display 14 is a light (e.g., a light emitting diode) with lit and unlit states or an audi... | 12/01/1998 |
| 5843468 | Skin permeation enhancer compositions comprising glycerol monolaurate and lauryl acetate Compositions, devices, and methods for transdermal administration of an active agent are disclosed using a novel dual permeation enhancer mixture comprising lauryl acetate and a monoglyceride, preferably glycerol monolaurate. The dual permeation enhancer ... | 12/01/1998 |
| 5840754 | Dosage form comprising oxybutynin A composition comprising oxybutynin, a device comprising oxybutynin, and a method for administering oxybutynin are disclosed for oxybutynin therapy.... | 11/24/1998 |
| 5840074 | Method and apparatus for delivering first agent followed by second agent The invention provides a dispensing device (10) comprising a loading dose (32) (first agent delivery device) for short-term and continuous delivery of agent, retained together with a long-term dispensing device (12) (second agent delivery device) capable ... | 11/24/1998 |
| 5840327 | Transdermal drug delivery device having enhanced adhesion A device for the transdermal administration of a drug to a sensitive body area such as the scrotum. Devices according to the invention provide an improved quality of adhesion to the body area while also providing patient comfort during use and upon remova... | 11/24/1998 |
| 5838571 | Tablet press monitoring and controlling method and apparatus Compression forces (F) in a rotary tablet compressing machine (40) are monitored and controlled to provide enhanced accuracy in determining peak compression value and continuous validation of a compression waveform. The compression waveform is repetitivel... | 11/17/1998 |
| 5830501 | Dosage form comprising hydrophilic polymer A dosage form is disclosed comprising means for lessening the tackiness and/or irritation of the components of the dosage form to mucosal tissue. The dosage form provides means for forming in the dosage form a floc comprising a drug, which floc, when deli... | 11/03/1998 |
