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Felix Hoffmann, a German chemist, was searching for something to relieve his father's arthritis. In doing so, he "rediscovered" acetylsalicylic acid and in 1900, patented a stable process for developing it. Hence, we have aspirin.
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| Number | Title | Issue Date |
| 8182435 | Intraocular pressure sensor An implantable intraocular pressure sensor system has a sealed geometric shape with an internal pressure at a first value. A strain gauge wire is embedded in a surface of the sealed geometric shape. When the surface is deflected by intraocular pressure, a measured r... | 05/22/2012 |
| 8178582 | Pharmaceutical compositions having desirable bioavailability The present invention is directed to the provision of pharmaceutical compositions. The compositions include a therapeutic agent and a relatively low amount of surfactant for providing higher bioavailability of the therapeutic agent. The compositions are particularly... | 05/15/2012 |
| 8173668 | Use of non-peptidic bradykinin receptor agonists to treat ocular hypertension and glaucoma The invention provides methods for treating and/or preventing ocular disorders associated with increased intraocular pressure comprising administering a non-peptide bradykinin agonist to a patient in need thereof. ... | 05/08/2012 |
| 8172786 | Method of operating an ultrasound handpiece A method of operating an ultrasonic handpiece by pulsing the power supplied to the handpiece and varying the type of vibration during the power pulse. ... | 05/08/2012 |
| 8168741 | Chelating silicon-based polymers The present invention relates to novel silicon-based polymers, particularly silicon-based polymers having citrate groups, and their use as chelating agents, for forming nanostructures, as surfactants, as reducing agents and as stabilizers. ... | 05/01/2012 |
| 8168609 | RNAi-mediated inhibition of Rho kinase for treatment of ocular disorders RNA interference is provided for inhibition of Rho kinase mRNA expression for treating patients with ocular disorders, particularly for treating intraocular pressure, ocular hypertension and glaucoma. Rho kinase mRNA targets include mRNA for ROCK1 and ROCK2. ... | 05/01/2012 |
| 8157797 | Capsularhexis device with retractable bipolar electrodes A capsularhexis device includes a loop-shaped cutting portion formed from flexible, superelastic metal strips separated by an insulating layer, and configured so that the cutting portion may be retracted into a tubular insertion cartridge for insertion into and remo... | 04/17/2012 |
| 8137344 | Flexible, automated capsulorhexis device A capsularhexis electrode device and corresponding insertion tool are disclosed. A flexible capsulorhexis electrode device comprises an elastomeric ring, first and second electrically conductive traces disposed at a first face of the elastomeric ring and extending c... | 03/20/2012 |
| 8136779 | Mounting arrangement for a pressurized irrigation system An irrigation mounting arrangement for an irrigation container that is defined by a body portion, a neck member, and a stopper, is disclosed. The irrigation mounting arrangement comprises an upwardly extending base member and a mounting arm mechanism that extends aw... | 03/20/2012 |
| 8128960 | Low viscosity, highly flocculated triamcinolone acetonide suspensions for intravitreal injection Triamcinolone acetonide suspension compositions are disclosed. The suspension compositions have a relatively low viscosity and are easy to extrude through a 27- or 30-gauge needle but are highly flocculated and easily redispersed. The compositions are particularly s... | 03/06/2012 |
| 8123687 | Intraocular pressure sensor An implantable intraocular pressure sensor system has a sealed geometric shape with an internal pressure at a first value. The sealed geometric shape has a first light permitting surface and a second flexible surface. A pair of photocells is located in the sealed ge... | 02/28/2012 |
| 8118790 | Battery operated surgical hand piece with disposable end The present invention is an ophthalmic injection system with a limited reuse assembly and a tip segment. The tip segment is connectable to and removable from the limited reuse assembly. The tip segment includes a dispensing chamber, a plunger, and a housing. The dis... | 02/21/2012 |
| 8109937 | Surgical system for indication of media types A surgical system includes a surgical instrument, an aspiration flow rate measurement device, a vacuum force measurement device, and an indicator. The surgical instrument has an aspiration portion and is located in a media type. The aspiration flow rate measurement ... | 02/07/2012 |
| 8101582 | Topical ophthalmic compositions containing tobramycin and dexamethasone Ophthalmic pharmaceutical compositions containing tobramycin, dexamethasone and deacetylated xanthan gum are described. The compositions provide longer ocular retention for enhanced ocular bioavailability of tobramycin and dexamethasone. In a preferred embodiment, t... | 01/24/2012 |
| 8093352 | Polyalkylene oxide polyquaternary ammonium biocides Disclosed are polyquaternary ammonium polymers containing polyalkylene oxide groups according to formula (I) wherein [A]x, [B]y and [C]z are poly(alkylene oxides) each independently selected from the group consisting of poly(ethylene... | 01/10/2012 |
| 8070711 | Thermal management algorithm for phacoemulsification system A control system for managing power supplied to a phacoemulsification hand piece includes a power source that provides power to the hand piece and a controller that controls the power source. The controller calculates a thermal value based on irrigation fluid flow a... | 12/06/2011 |
| 8062260 | Trocar cannula device with retention feature A trocar cannula is disclosed. The trocar cannula comprises a cannula having at least one tab member formed therein. Each tab member is configured to provide a retention force between the cannula and tissue when the tab member is placed in a deformed position. The t... | 11/22/2011 |
| 8048863 | RNAi-mediated inhibition of spleen tyrosine kinase-related inflammatory conditions RNA interference is provided for inhibition of spleen tyrosine kinase (Syk) mRNA expression, in particular, for treating patients having a Syk-related inflammatory condition or at risk of developing a Syk-related inflammatory condition such as allergic conjunctiviti... | 11/01/2011 |
| 8034839 | Method of treating ocular allergy The topical use of 5,6,7-trihydroxyheptanoic acid and analogs alone or in combination with histamine antagonists and/or mast cell stabilizers is disclosed for the treatment of ocular allergy. ... | 10/11/2011 |
| 8017592 | RNAi-mediated inhibition of histamine receptor H1-related conditions RNA interference is provided for inhibition of histamine receptor H1 mRNA expression, in particular, for treating patients having an HRH1-related condition or at risk of developing an HRH1-related condition such as allergic conjunctivitis, ocular inflammation, derma... | 09/13/2011 |
| 7982056 | Substantially pure fluorescein The present invention is directed to an improved process for producing substantially pure fluorescein, as well as to substantially pure fluorescein compositions prepared by the process. The invention is particularly directed to the provision of pharmaceutical compos... | 07/19/2011 |
| 7981870 | RNAi-mediated inhibition of H1F1A for treatment of ocular angiogenesis RNA interference is provided for inhibition of HIF1A mRNA expression for treating patients with ocular angiogenesis, particularly for treating retinal edema, diabetic retinopathy, sequela associated with retinal ischemia, posterior segment neovascularization (PSNV),... | 07/19/2011 |
| 7973019 | Transferrin/transferrin receptor-mediated siRNA delivery The invention provides interfering RNA molecule-ligand conjugates useful as a delivery system for delivering interfering RNA molecules to a cell in vitro or in vivo. The conjugates comprise a ligand that can bind to a transferrin receptor (TfR). Therapeutic uses for... | 07/05/2011 |
| 7909800 | Juxtascleral drug delivery and ocular implant system Ophthalmic drug delivery devices useful for delivery of pharmaceutically active agents to the posterior segment of the eye are disclosed. ... | 03/22/2011 |
| 7888370 | Topical ophthalmic or otic solution formulations containing moxifloxacin hydrochloride and dexamethasone phosphate Topical ophthalmic and otic solution compositions of moxifloxacin and dexamethasone phosphate are disclosed. ... | 02/15/2011 |
| 7887521 | Ophthalmic injection system An ophthalmic injection system has a tip segment attachable to and removable from a limited reuse assembly. The tip segment has a dispensing chamber housing, a plunger, a needle, a temperature control device, a thermal sensor, and a first housing at least partially ... | 02/15/2011 |
| 7887517 | Drug casting An injection device assembly includes a dispensing chamber housing and a plunger. The dispensing chamber housing is coupled to a needle. The dispensing chamber housing has an inner surface and an outer surface. The inner surface partially defines a dispensing chambe... | 02/15/2011 |
| 7879813 | Interfering RNA delivery system and uses thereof The invention provides a delivery system comprising a cell penetrating peptide, a polyarginine peptide, and an interfering RNA molecule. The system can be used for delivering interfering RNA molecules into a cell in vivo or in vitro. Therapeutic uses for the deliver... | 02/01/2011 |
| 7879006 | Injection aid for anterior juxtascleral depot The present invention is an ophthalmic injection aid having a positioning member and a needle assembly. The injection aid facilitates the creation of an anterior juxtascleral depot of an ophthalmic drug. ... | 02/01/2011 |
| 7871399 | Disposable ophthalmic injection device A disposable injection device has a dispensing chamber housing, a plunger, a needle, and a temperature control device. The dispensing chamber housing has an inner surface and an outer surface. The inner surface partially defines a dispensing chamber for receiving a ... | 01/18/2011 |
| 7867999 | Hydroxyamino- and amino-substituted pyridine analogs for treating rho kinase-mediated diseases and conditions Methods for using hydroxyamino- and amino-substituted pyridine analogs are disclosed herein to treat rho kinase-mediated diseases or rho kinase-mediated conditions, including controlling intraocular pressure and treating glaucoma, are disclosed. Ophthalmic pharmaceu... | 01/11/2011 |
| 7862540 | Ophthalmic injection device using shape memory alloy An ophthalmic injection device has a dispensing chamber housing, a needle fluidly coupled to a dispensing chamber, a power source for providing current to the dispensing chamber housing, a controller for controlling the power source, and a housing at least partially... | 01/04/2011 |
| 7820670 | 6-aminoimidazo[1,2-b]pyridazine analogs as rho kinase inhibitors for the treatment of rho kinase-mediated diseases and conditions Methods for using 6-aminoimidazo[1,2-b]pyridazine analogs are disclosed herein to treat rho kinase-mediated diseases or rho kinase-mediated conditions, including controlling intraocular pressure and treating glaucoma, are disclosed. Ophthalmic pharmaceutical composi... | 10/26/2010 |
| 7815603 | Ophthalmic injection method A method of delivering a substance into an eye includes recognizing a connection between a tip segment and a limited reuse assembly; receiving dosage information from the tip segment; activating a temperature control device to alter a temperature of a substance to b... | 10/19/2010 |
| 7811252 | Dosage control device An injection device includes a dispensing chamber, a plunger, a controller, a memory device resistant to sterilization, and a housing at least partially enclosing the dispensing chamber and the plunger. The dispensing chamber has an inner surface and an outer surfac... | 10/12/2010 |
| 7807629 | Use of bradykinin and related BR agonists to treat ocular hypertension and glaucoma The invention provides methods for treating and/or preventing ocular disorders associated with increased intraocular pressure comprising administering a bradykinin B2 receptor agonist to a patient in need thereof. ... | 10/05/2010 |
| 7807363 | Superoxide dismutase-2 expression for glaucoma diagnosis The present invention concerns a method for diagnosing or monitoring elevated intraocular pressure or glaucoma in a patient comprising providing a biological sample from the patient and measuring the expression level of a superoxide dismutase-2 (SOD-2) gene in the b... | 10/05/2010 |
| 7806865 | Pressurized irrigation squeeze band A pressurized infusion device has a flexible band with first and second ends, a curved base, and a bag containing fluid. The bag is located between the flexible band and the curved base. The second end of the flexible band is coupled to a shaft. A motor is also coup... | 10/05/2010 |
| 7795316 | Topical ophthalmic compositions containing tobramycin and dexamethasone Ophthalmic pharmaceutical compositions containing tobramycin, dexamethasone and deacetylated xanthan gum are described. The compositions provide longer ocular retention for enhanced ocular bioavailability of tobramycin and dexamethasone. In a preferred embodiment, t... | 09/14/2010 |
| 7777872 | Method of measuring diffractive lenses A method for measuring the optical properties of multifocal ophthalmic lenses. Collimated light is passed through an ophthalmic lens and onto an array of lenslets. Light exiting the array of lenslets is detected by a sensor. Blurred spots and/or double spots may rep... | 08/17/2010 |
