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Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem


Location: Jerusalem, IL
No. of applications: 37

Application No.Application TitleIssue Date
20090155345METHODS FOR AFFECTING LIPOSOME COMPOSITION ULTRASOUND IRRADIATION
The present invention provides methods for loading of agents and substances into per-formed liposomes, preferably a suspension of pre-formed liposomes as well as to methods for the controlled quantum (step-wise) release of agents and substances from liposomes. One of th...
06/18/2009
20090104202CD44 polypeptides, polynucleotides encoding same, antibodies directed thereagainst and method of using same for diagnosing and treating inflammatory diseases
An isolated polypeptide is provided. The isolated polypeptide comprising an antigen recognition domain capable of specifically binding a CD44 polypeptide as set forth in SEQ ID NO: 2 and incapable of binding a CD44 polypeptide selected from the group consisting of: SEQ ...
04/23/2009
20090093053CD44 polypeptides, polynucleotides encoding same, antibodies directed thereagainst and method of using same for diagnosing and treating inflammatory diseases
An isolated polypeptide is provided. The isolated polypeptide comprising an antigen recognition domain capable of specifically binding a CD44 polypeptide as set forth in SEQ ID NO: 2 and incapable of binding a CD44 polypeptide selected from the group consisting of: SEQ ...
04/09/2009
20090082549FcE-PE chimeric protein for targeted treatment of allergy responses a method for its production and pharmaceutical compositions containing the same
The present invention generally relates to a new approach for the therapy of allergic responses, based on targeted elimination of cells expressing the FcεRI receptor by a chimeric cytotoxin FC2′-3-PE40. A sequence encoding amino acids 301-437 of...
03/26/2009
20080306014Agents, compositions and methods for treating pathologies in which regulating an ache-associated biological pathway is beneficial
The present invention provides agents which are capable of regulating the function of a micro-RNA component which can be used to regulate an AChE-associated biological pathway. In addition, the present invention provides methods and pharmaceutical compositions for the t...
12/11/2008
20080262321Early Detection of Harmful Agents: Method, System and Kit
A portable system for detecting agents present in a sample is disclosed. The system comprises a sensing device, having a substrate formed with a plurality of reaction chambers and a plurality of channels interconnecting at least a portion of the plurality of reaction ch...
10/23/2008
20080213353Method for preparing liposome formulations with a predefined release profile
The present invention provides a novel tool for designing a release profile of an active agent from a liposome in to which it is loaded. According to the invention, a method is provided for preparing a liposomal formulation for delivery of an active agent to a target, t...
09/04/2008
20080210122Ink for Ceramic Surfaces
The present invention concerns ink for printing on ceramic surfaces such as glass, which contains glass frits for silica nanoparticles and optionally a pigment, and is suitable for ink jet printing....
09/04/2008
20080139651COMPOUNDS USEFUL FOR TREATING NEUROLOGICAL DISORDERS
The invention relates to the use of compounds for the preparation of a medicament for treating neuropathic pain, migraine, psychiatric disorder and/or neuronal degeneration. The invention additionally relates to a pharmaceutical composition comprising compounds for trea...
06/12/2008
20080139460Binding agents for CD44 glycoproteins and methods of use
The present invention is based on the finding that Gal-8 binds to carbohydrates of cell surface CD44std and CD44v and activates a chain of biological events within the cells. A specific effect exhibited was the induction of apoptosis in the CD44std and CD44v expressing ...
06/12/2008
20080128761Novel Nanostructures And Method For Selective Preparation
The present invention provides novel nanostructure composed of at least one elongated structure element, an elongated structure element of said nanostructure bearing a different zone made of metal, metal alloy, conductive polymer or semiconductor and selectively grown o...
06/05/2008
20070292930Method of producing recombinant Aspergillus niger beta-glucosidase and an aroma spreading plant
A polypeptide having β-glucosidase enzymatic activity, a polynucleotide encoding the polypeptide, a nucleic acid constructs carrying the polynucleotide, transformed or infected cells, such as yeast cells, and transgenic organisms expressing the polynucleotide and vario...
12/20/2007
20070287662Multi-component antioxidant compounds, pharmaceutical compositions containing same and their use for reducing or preventing oxidative stress
An antioxidant compound is disclosed. The compound is characterized by (a) a peptide including at least three amino acid residues of which at least two are cysteine residues, each having a readily oxidizable sulfhydryl group for effecting antioxidation; and at least two...
12/13/2007
20070264273SPHINGOID POLYALKLAMINE CONJUGATES, ISOMERS AND USES THEREOF
The present application discloses methods for stimulating or enhancing an immune response of a subject to protect against an infection caused by an agent selected from Hepatitis B Virus (HBV), avian influenza virus, the bacterium Bacillus anthracis or the bacteri...
11/15/2007
20070212403Method for Selecting Cationic or Anionic Liposomes for Treatment of a Mucosa Membrane, and Kit Comprising the Same
The present invention is based on the use of electrical surface charge as a docking tool to bring charged lipid assemblies in the vicinity of a diseased, e.g. inflamed epithelium of the mucosa, or alternatively, to a normal epithelium, for executing a desired medical pr...
09/13/2007
20070212353Novel therapeutic target and diagnostic marker for asthma and related conditions
CD48, a surface-marker molecule present in eosinophils, is disclosed herein as a key molecule in allergic conditions, particularly in allergic airway inflammations like asthma, allergy and nasal polyposis. CD48 is thus presented as a target molecule in the treatment of ...
09/13/2007
20070049645Anti-nausea and anti-vomiting activity of cannabidiol compounds
The present invention relates the use of certain cannabidiol derivatives and of their dimethyl heptyl homologs (CBD-DMH) in the treatment of nausea, in particular chemotherapy-induced nausea, and of anti vomiting activity. The present invention relates also to the use o...
03/01/2007
20070036764Selective killing of cells by activation of double-stranded RNA dependent protein kinase-PKR
Novel methods and compositions for selective killing of cells by activation of PKR are disclosed. In a preferred embodiment, a method is provided for causing cell death in a targeted population of cells that includes the steps of: selecting a nucleotide sequence at a si...
02/15/2007
20060280334Fast and robust motion computations using direct methods
A respective intensity gradient of a first spatially aligned pixel in each frame of a sequence of images is multiplied by a respective intensity or function thereof of a second pixel in the new frame, this being done for all pixels in the set and the resulting products ...
12/14/2006
20060262184Method and system for spatio-temporal video warping
A computer-implemented method and system for transforming a first sequence of video frames of a first dynamic scene captured at regular time intervals to a second sequence of video frames depicting a second dynamic scene wherein for at least two successive frames of the...
11/23/2006
20060246095Multiepitope polypeptides for cancer immunotherapy
Disclosed are recombinant multiple epitope polypeptides (MEPs) consisting of T cell epitopes derived from tumor-associated antigens capable of being presented by an antigen presenting cell (APC), the recombinant nucleic acid sequences and expression vectors encoding the...
11/02/2006
20060222650Broad spectrum pyrogenic antagonists and vaccines directed against pyrogenic exotoxins
The invention relates to peptides comprising an amino acid sequence homologous to the amino sequence of a fragment of a pyrogenic exotoxin, and functional derivatives of said peptides, capable of eliciting protective immunity against toxic shock induced by a pyrogenic e...
10/05/2006
20060171956Sphingoid polyalkylamine conjugates for hepatitis B virus vaccination
The present invention concerns the use of a sphingoid-polyalkylamine conjugate as a capturing agent of biologically active molecules, such as antigens. In a particular embodiment, the spinogid-polyalkylamines are used for the preparation of pharmaceutical composition fo...
08/03/2006
20060159731Multi-layer collagenic article useful for wounds healing and a method for its production thereof
A multi-layer collagen article useful for wound healing includes at least two layers; wherein at least one layer, facing the wound side, has an effective amount of non or partially cross-linked collagen; and at least one layer having an effective amount of highly cross-...
07/20/2006
20060154859Leptin antagonists
The invention relates to synthetic leptin antagonists in which at least two amino acid residues of the sequence LDFI/S of the hydrophobic binding site at positions 39-42 of a leptin polypeptide sequence are substituted with different amino acid residues such that the si...
07/13/2006
20060111328Carbamoyl-and thiocarbamoyl-phosphonates and pharmaceutical compositions comprising them
The present invention provides a compound of the following formula I:
R3—NH—C(═X)—P(═O)OR1OR2 including pharmaceutically acceptable salts, solvates, hydrates and polymorphs of the compound...
05/25/2006
20060084176Detection of uronium salts
Methods and kits for colorimetric identification of uronium salts, such as explosives. ...
04/20/2006
20060069053Methods and compositions for enhancing cartilage repair
The invention relates to methods of enhancing repair of a cartilage and/or inducing formation of a cartilage by administering a cell, which expresses a factor of the T-box family, which includes inter-alia the brachyury. In another embodiment, the invention relates to a...
03/30/2006
20050253854Method and system for performing computer graphic simulation of a fluid using target-driven control
Method and system for efficiently controlling animated smoke which utilizes a sequence of target smoke states to generate a smoke simulation in which the smoke is driven towards each of these targets in turn, while exhibiting natural-looking interesting smoke-like behav...
11/17/2005
20050232979Multi-layer collagenic article useful for wounds healing
The invention relates to a multi-layer collagen article useful for wound healing, comprising at least two layers; wherein at least one layer, facing the wound side, is comprising an effective amount of non or partially cross-linked collagen; and at least one layer compr...
10/20/2005
20050167646Nanosubstrate with conductive zone and method for its selective preparation
The present invention provides novel nanostructure composed of at least one elongated structure element, an elongated structure element of said nanostructure bearing an electrically conductive zone selectively grown onto the elongated structure element. The present inve...
08/04/2005
20050165128Responsive biomedical composites
A responsive polymeric system including a responsive polymeric component capable of undergoing a transition that results in a sharp increase in viscosity in response to a triggering effected at a predetermined body site. The system includes a solid non-ceramic reinforci...
07/28/2005
20050111753Image mosaicing responsive to camera ego motion
A method of generating a mosaic from a plurality of camera images of a scene acquired by a camera moving relative to the scene, the method comprising: associating with each camera image a value of at least one variable so that the variable is a substantially a linear fu...
05/26/2005
20050069573Responsive polymeric system
A novel environmentally responsive polymeric system is provided for biomedical applications, comprising silicon-containing reactive groups which undergo a hydrolysis-condensation reaction at a predetermined body site and thereby change rheological and mechanical propert...
03/31/2005
20050058744Edible compositions capable of removing oral biofilm
An edible and/or chewable article of manufacture containing at least one food grade substance having adsorption affinity towards at least one dental plaque (biofilm) constituent and capable of reducing and/or removing the oral biofilm while present in the mouth. Particu...
03/17/2005
20050010114Optical mammography
Apparatus for imaging of the inner structure of the breast, the apparatus comprising: a source of light illuminating the breast when the source of light is situated at a first position of the breast; and a detector which when situated at a second position relative to th...
01/13/2005
20050004037Osteogenic growth oligopeptides as stimulants of hematopoiesis
The present invention relates to a pharmaceutical composition comprising as an effective ingredient an oligopeptide identical or analogous to the C-terminal portion of OGP, having stimulatory activity on the production of hematopoietic cells. Preferred oligopeptides tha...
01/06/2005
 
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