Did You Know...
...that power steering was invented by independent inventor Francis W. Davis? As chief engineer in the 1920s of the truck division of the Pierce Arrow Motor Car Company, he saw how hard it was to steer heavy vehicles. So that he would be able to keep the profits from his future invention, Davis left his job, rented a small engineering shop in Waltham, Mass., and developed a hydraulic power steering system that led to power steering.
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| Application No. | Application Title | Issue Date |
| 20120130384 | Apparatus for Osteotomy and Graft Preparation Surgical tools that increase surgical accuracy for orthopedic procedures involving long bone osteotomy with or without supplementation with allograft or autograft. Two clamps on the operative side are rigidly interconnected to one another with an adjustable rod that is ... | 05/24/2012 |
| 20120128551 | IONIC LIQUID MEDIATED SOL-GEL SORBENTS Ionic liquid (IL)-mediated sol-gel hybrid organic-inorganic materials present enormous potential for effective use in analytical microextraction. One obstacle to materializing this prospect arises from high viscosity of ILs significantly slowing down sol-gel reactions. ... | 05/24/2012 |
| 20120067529 | SHAPE-SHIFTING SURFACES Shape-shifting surfaces that retain their effectiveness as physical barriers while undergoing changes in shape. The shape changes include any motion that makes the surface more effective at performing its function, such as expansion, shrinkage, twisting, encircling, wig... | 03/22/2012 |
| 20120053911 | Gene Signature for the Prediction of Radiation Therapy Response Described are mathematical models and method, e.g., computer-implemented methods, for predicting tumor sensitivity to radiation therapy, which can be used, e.g., for selecting a treatment for a subject who has a tumor.... | 03/01/2012 |
| 20120039854 | Nanoparticle Targeted Drug Delivery to the Lungs Using Extra-Testicular Sertoli Cells A method of delivering a compound of interest to the lungs of a subject by the intravenous injection of Sertoli cells loaded with a plurality of chitosan nanoparticles coupled with the compound of interest is provided. Testis-derived rat Sertoli cells were pre-loaded wi... | 02/16/2012 |
| 20120034614 | EARLY DETECTION OF PATHOGENS IN BLOOD The present invention is a method of extracting infectious pathogens from a volume of blood including the steps of creating a fibrin aggregate confining the pathogens and introducing a fibrin lysis reagent to expose the pathogens for analysis. The fibrin lysis reagent i... | 02/09/2012 |
| 20120034186 | INDOLINE SCAFFOLD SHP-2 INHIBITORS AND METHOD OF TREATING CANCER Protein tyrosine phosphatase (PTP) Shp2 is a non-receptor PTP that involved in cell signaling and regulation of cell proliferation, differentiation, and migration. Shp2 mediates activation of kinases that are involved in the pathogenesis of human carcinoma. A high throu... | 02/09/2012 |
| 20120029067 | Polyphenol Proteasome Inhibitors, Synthesis, and Methods of Use The present invention relates to synthetic green tea derived polyphenolic compounds, their modes of syntheses, and their use in inhibiting proteasomal activity and in treating cancers. The present invention is also directed to pharmaceutical compositions useful in metho... | 02/02/2012 |
| 20120024790 | SEPARATION COLUMN WITH GERMANIA-BASED SOL-GEL STATIONARY PHASE The present invention provides sol-gel germania-coated chromatography separation columns with improved stability under extreme pHs and high temperatures. Also provided are methods of preparation and uses of the sol-gel germania-coated separation columns of the present i... | 02/02/2012 |
| 20120022007 | METHOD AND COMPOSITION FOR MODULATING CANONICAL WNT PATHWAY USING FOLATE AND INOSITOL The canonical Wnt signaling pathway is implicated in many disorders including neural tube defects, limb malformations, and heart defects, developmental disorders associated with alcohol exposure (fetal alcohol syndrome) or exposure to bipolar medications (i.e. lithium),... | 01/26/2012 |
| 20110275384 | ADAPTIVE LOCATION DATA BUFFERING FOR LOCATION-AWARE APPLICATIONS A method of buffering location data on a mobile device. The method transmits location data packets via an unreliable protocol to a receiving device and buffers a copy of the location data packet. Periodically, the method also transmits a location data packet via a relia... | 11/10/2011 |
| 20110274674 | ISCHEMIC TISSUE CELL THERAPY The present invention is directed to compositions and methods for treatment of ischemic diseases and conditions, particularly myocardial, CNS/brain and limb ischemia. More particularly, the present invention provides methods of treating disorders by administering monocy... | 11/10/2011 |
| 20110268710 | METHODS OF TREATING STROKE USING STEM CELL-LIKE MENSTRUAL BLOOD CELLS A cell type that is a complete match of the transplant recipient appears as an optimal scenario to open treatment options to a large patient population with minimal complications. The use of autologous bone marrow or umbilical cord blood has been proposed as a good sour... | 11/03/2011 |
| 20120015993 | Novel Pharmaceutical Forms, and Methods of Making and Using the Same Crystalline salts, polymorphs, solvates, and hydrates of bicalutamide, 5-fluorouracil, donepezil, anastrozole, nelfinavir, mirtazapine, lansoprazole, and tamsulosin, or derivatives thereof are provided by the subject invention. Methods of making and using the same are a... | 01/19/2012 |
| 20120009271 | METHOD OF DISEASE-INDUCED AND RECEPTOR-MEDIATED STEM CELL NEUROPROTECTION Stem cells are exposed to disease condition (the OGD stroke model), that mimics the target disease (stroke), allowing the stem cells to exert better neuroprotective effects. Thus, the present technology demonstrates a disease-tailored stem cell therapy. The present inve... | 01/12/2012 |
| 20120006314 | SUSTAINED MODULATION OF TEMPERATURE OF SELF HEATING CHEMICAL SYSTEM Exothermic reactions are used in self heating products, such as food, beverages, and clothing. Temperature peaks are important as heat can cause user injuries or increase pressures within the heating container to unsafe levels. Disclosed is a composition that modulates ... | 01/12/2012 |
| 20120004434 | GERMANIA-SILICA-BASED SOL-GEL MONOLITH AND USES THEREOF The present invention provides germania-silica-based sol-gel monoliths that form the solid-phase material for extraction, isolation, preconcentration, and separation of analytes. In one embodiment, the germania-silica-based sol-gel monolith can be used to coat surfaces ... | 01/05/2012 |
| 20120004169 | MATERIALS AND METHODS FOR TREATMENT OF CANCER AND IDENTIFICATION OF ANTI-CANCER COMPOUNDS The subject invention pertains to the treatment of tumors and cancerous tissues and the prevention of tumorigenesis and malignant transformation through the modulation of JAK/STAT3 intracellular signaling. The subject invention concerns pharmaceutical compositions conta... | 01/05/2012 |
| 20120001094 | DEEP-UV LED AND LASER INDUCED FLUORESCENCE DETECTION AND MONITORING OF TRACE ORGANICS IN POTABLE LIQUIDS An apparatus for measuring fluorescence of potable liquids contained within an optical quartz cell includes a deep UV laser or a compact UV LED that generates a light beam. A UV blocking and visible light transmitting optical filter reduces out-of-band emission from the... | 01/05/2012 |
| 20120000850 | SOL-GEL MONOLITHIC COLUMN WITH OPTICAL WINDOW AND METHOD OF MAKING A method of preparing a sol-gel monolithic column includes the step of forming a separation bed (14) from a sol-gel solution in a single process step. This column has improved characteristics for CEC based on its incorporated surface charge and ease of operation ... | 01/05/2012 |
| 20110318763 | DETECTION OF CANCER BY ELEVATED LEVELS OF BCL-2 The present invention relates to a method for the diagnosis, prognosis, and monitoring of cancer, such as early or late stage ovarian cancer, in a subject by detecting Bcl-2 in a biological sample from the subject, preferably a urine or blood sample. Bcl-2 may be measur... | 12/29/2011 |
| 20110311473 | METHODS OF TREATING COGNITIVE IMPAIRMENT The subject invention concerns materials and methods for treating a person or animal having cognitive impairment. In one embodiment, the method comprises administering an effective amount of one or more inflammatory mediator(s), for example, fms-related tyrosine kinase ... | 12/22/2011 |
| 20110301159 | KINASE INHIBITOR COMPOUNDS The disclosure relates to novel compounds that are capable of modulating Jak2 kinase activities, compounds that have therapeutic use in treating or preventing a subject suffering from or susceptible to a Jak2 mediated disease or disorder, and methods of use and composit... | 12/08/2011 |
| 20110288890 | COMPUTER SYSTEMS AND METHODS FOR SELECTING SUBJECTS FOR CLINICAL TRIALS Computers, computer program products, and methods for identifying a plurality of subjects for a clinical trial are provided. A candidate set of molecular profiles in a stored plurality of molecular profiles are identified. Each such profile has measurements for a discri... | 11/24/2011 |
| 20110246606 | ARCHITECTURE AND TWO-LAYERED PROTOCOL FOR REAL-TIME LOCATION-AWARE APPLICATIONS A two-layer communication protocol that supports efficient real-time location-aware application on multiple mobile devices that must communicate with each other and/or a centralized server. The two-layer protocol includes a method of communicating data between a first m... | 10/06/2011 |
| 20110244570 | VOLUME EXCLUSION AGENT TO ENHANCE FORMATION OF EXTRACELLULAR MATRIX A method of enhancing the formation of extracellular matrix in culture. Cells in culture secrete most of the collagen into the media as unprocessed procollagen, i.e., the cells do not convert procollagen to collagen. In contrast, normal extracellular matrix deposition i... | 10/06/2011 |
| 20110243957 | MATERIALS AND METHODS FOR PREVENTING OR TREATING NEURODEGENERATIVE CONDITIONS ASSOCIATED WITH ABETA PEPTIDE ACCUMULATION The subject invention concerns methods for preventing and/or treating neurodegenerative conditions associated with Abeta peptide accumulation in neural tissue in a human or animal. The subject invention also concerns methods for preventing or treating Alzheimer's diseas... | 10/06/2011 |
| 20110236471 | PLATINUM COMPLEXES AND METHODS FOR INHIBITING TUMOR CELL PROLIFERATION The subject invention concerns platinum complexes that exhibit antitumor cell and/or antiparasitic activity. The subject invention also concerns the use of platinum complexes of the invention to treat oncological and inflammatory disorders. The platinum complexes of the... | 09/29/2011 |
| 20110223608 | MOLECULAR DETECTION AND QUANTIFICATION OF ENTEROCOCCI A primer pair and probe for the large subunit ribosomal RNA gene of enterococci for use in a real-time nucleic acid sequence based amplification (NASBA) assay.... | 09/15/2011 |
| 20110223154 | COMPOSITIONS INCLUDING TRICIRIBINE AND METHODS OF USE THEREOF This invention encompasses combination therapies including TCN, TCN-P, TCN-PM and/or related compounds and one or more additional anti-cancer agents, for example, taxanes a molecule that modulates the HER2/neu (erbB2) receptor, anthracyclin compounds, epidermal growth f... | 09/15/2011 |
| 20110217460 | SELF-ASSEMBLING, COLLAGEN-BASED MATERIAL FOR CORNEAL REPLACEMENT A material derived from sea cucumber collagen fibrils is suitable for use in corneal replacements or as an implantable contact lens. To produce material, the collagen fibrils are centrifuged into orthogonal stacks of lamellae comprised of aligned fibrils. The resulting ... | 09/08/2011 |
| 20110212443 | Method for determining the specific growth rate of distinct microbial populations in a non-homogeneous system The present invention pertains to a molecular biology-based method and kit for measuring the specific growth rate (or cell doubling time) of distinct microbial populations. The method and kit can be used to analyze mixed culture samples that have been exposed to chloram... | 09/01/2011 |
| 20110201688 | N,N'-DI-P-BROMOPHENYL GUANIDINE TREATMENT FOR STROKE AT DELAYED TIMEPOINTS 1,3 di-o-tolylguanidine (DTG) was examined as anti-stroke drug with a broad therapeutic window. DTG activates sigma 1 and 2 receptors. Administration of DTG at 24 hours post-stroke to rats reduces neurodegeneration by 85%; this is the only pharmacological agent that has... | 08/18/2011 |
| 20110201609 | PROTEASOME INHIBITORS FOR SELECTIVELY INDUCING APOPTOSIS IN CANCER CELLS The subject invention concerns compounds having activity as inhibitors of proteasomes and methods of using the subject compounds. In one embodiment, a compound of the invention has the chemical structure shown in formula I: 08/18/2011 | |
| 20110201576 | Small molecule inhibitors of stat3 with anti-tumor activity The present invention concerns compounds, compositions containing these compounds, and methods of using these compounds and compositions as inhibitors of Stat3 signaling, Stat3 dimerization, Stat3-DNA binding, Stat5-DNA binding, and/or aberrant cell growth in vitro or i... | 08/18/2011 |
| 20110201565 | LUTEOLIN AND DIOSMIN/DIOSMETIN AS NOVEL STAT3 INHIBITORS FOR TREATING AUTISM The present invention includes methods for the treatment of autoimmune disorders such as autism, schizophrenia, and type 1 diabetes. Flavonoids, luteolin, diosmin, and diosmin's aglycone form, diosmetin, were found to inhibit activation/phosphorylation of STAT3 induced ... | 08/18/2011 |
| 20110190315 | INDOLINE SCAFFOLD SHP-2 INHIBITORS AND CANCER TREATMENT METHOD The subject invention concerns methods and compounds for inhibiting Shp2. In one embodiment, a compound of the invention has a chemical structure as shown in formula I or II: wherein | 08/04/2011 |
| 20110186522 | REMOVAL OF NUISANCE ANION AND ANIONIC MATERIALS USING POLYALKYLENEIMINES SUCH AS POLYETHYLENEIMINE The present invention features a method of removing one or more nuisance anionic materials, such as pharmaceuticals and dyes, from a solution, such as wastewater. Related aspects of the invention include an apparatus and kits for carrying out the methods of the inventio... | 08/04/2011 |
| 20110166095 | CANCER PLATINUM RESISTANCE DETECTION AND SENSITIZATION METHOD The phosphorylation status of the BAD protein is a determinant of ovarian cancer cell responsiveness to platinum chemotherapy. Indirect manipulation of BAD phosphorylation status influences cisplatin sensitivity. BAD phosphorylation represents a biomarker that predicts ... | 07/07/2011 |
| 20110160178 | HETEROSUBSTITUTED N-THIOLATED BETA-LACTAM COMPOUNDS AND METHODS OF USE The invention relates to heterosubstituted N-thiolated beta-lactams, compositions comprising these compounds, methods for their production, and methods of use as antibiotics to inhibit the growth of bacteria. In one embodiment, the compounds have the structure shown in ... | 06/30/2011 |
