Assignee: The University of North Carolina at Chapel Hill

Location: Not specified.
No. of applications: 47

Browse patents
Browse applications

Application No.	Application Title	Issue Date
20120039896	METHOD FOR INHIBITING CELLULAR ACTIVATION BY INSULIN-LIKE GROWTH FACTOR-1 A method of inhibiting cellular activation by Insulin-like Growth Factor-1 (IGF-1) in a subject in need thereof (e.g., a subject afflicted with cancer, atherosclerosis, diabetic retinopathy or other disease) comprises administering an antagonist that inhibits the bindin...	02/16/2012
20120027278	METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR MAPPING REGIONS IN A MODEL OF AN OBJECT COMPRISING AN ANATOMICAL STRUCTURE FROM ONE IMAGE DATA SET TO IMAGES USED IN A DIAGNOSTIC OR THERAPEUTIC INTERVENTION Methods, systems, and computer readable media for mapping a model of an object comprising an anatomical structure in a planning image and an intervention target region within it to intervention-guiding image data are disclosed. According to one method, an initial medial...	02/02/2012
20110152229	BETULINIC ACID DERIVATIVES AS ANTI-HIV AGENTS The present invention provides compounds of the general structure: which are substituted at the 3 and 28 positions, along with pharmaceutical formulations containing the same and methods of treating viral inf...	06/23/2011
20110135610	Multipotent stem cells from the extrahepatic biliary tree and methods of isolating same The present invention relates to a multipotent stem cell, multipotent cell populations, and an enriched multipotent cell population, each found in fetal, neonatal, pediatric, and adult biliary tree tissue and up to 72 hours post mortem (although preferentially, within 1...	06/09/2011
20110124000	METHODS AND COMPOSITIONS FOR VITAMIN K EPOXIDE REDUCTASE The present invention provides a method of identifying a human subject having increased or decreased sensitivity to warfarin, comprising detecting in the subject the presence of a single nucleotide polymorphism in the VKOR gene, wherein the single nucleotide polymorphis...	05/26/2011
20110123446	DEGRADABLE COMPOUNDS AND METHODS OF USE THEREOF, PARTICULARLY WITH PARTICLE REPLICATION IN NON-WETTING TEMPLATES The present invention provides compounds that will degrade under specified conditions, methods of using such compounds, and compositions comprising such compounds. The degradable compounds of the invention may be characterized by the labile —Si-A-C— groups present i...	05/26/2011
20110027806	FARNESYLTRANSFERASE INHIBITORS FOR TREATMENT OF LAMINOPATHIES, CELLULAR AGING AND ATHEROSCLEROSIS Although it can be farnesylated, the mutant lamin A protein expressed in Hutchinson Gilford Progeria Syndrome (HGPS) cannot be defarnesylated because the characteristic mutation causes deletion of a cleavage site necessary for binding the protease ZMPSTE24 and effecting...	02/03/2011
20100330059	CHIMERIC FACTOR VII MOLECULES The present invention relates to chimeric Factor VII polypeptides and methods of using the same....	12/30/2010
20100310516	Duplexed Parvovirus Vectors The present invention provides duplexed parvovirus vector genomes that are capable under appropriate conditions of forming a double-stranded molecule by intrastrand base-pairing. Also provided are duplexed parvovirus particles comprising the vector genome. Further discl...	12/09/2010
20100303776	Methods and compositions for regulated expression of multiple nucleic acids The present invention provides a cell comprising a first heterologous nucleic acid construct and a second heterologous nucleic acid construct, wherein each of said first and second heterologous nucleic acid constructs comprises: A. a first nucleotide sequence encoding a...	12/02/2010
20100292088	METHODS AND COMPOSITIONS FOR DETECTING GENETIC MARKERS ASSOCIATED WITH PRIMARY CILIARY DYSKINESIA The present invention provides methods and compositions for detecting mutations in a DNAH11 gene of a subject to diagnose primary ciliary dyskinesia (PCD) in the subject and/or to identify a subject as having an increased risk of having PCD and/or to identify a carrier ...	11/18/2010
20100255586	METHODS AND COMPOSITIONS FOR PRODUCING VITAMIN K DEPENDENT PROTEINS The present invention relates to methods and compositions for improving the productivity of recombinant vitamin K dependent protein expression in host cells....	10/07/2010
20100215640	METHOD FOR INHIBITING CELLULAR ACTIVATION BY INSULIN-LIKE GROWTH FACTOR-1 A method of inhibiting cellular activation by Insulin-like Growth Factor-1 (IGF-1) in a subject in need thereof (e.g., a subject afflicted with cancer, atherosclerosis, diabetic retinopathy or other disease) comprises administering an antagonist that inhibits the bindin...	08/26/2010
20100197015	HUMAN LIVER PROGENITORS Methods of isolating and cryopreserving progenitors from human liver are disclosed which include processing human liver tissue to provide a substantially single cell suspension comprising progenitors and non-progenitors of one or more cell lineages found in human liver;...	08/05/2010
20090325297	METHOD FOR INHIBITING EXPRESSION OF A PROTEIN IN A HEPATOCYTE A method of screening a candidate compound for susceptibility to biliary excretion by a hepatocyte transport protein. The method includes the steps of providing a culture of hepatocytes comprising a transport protein, the culture having at least one bile canaliculus; ex...	12/31/2009
20090291450	CATERPILLER GENE FAMILY The present invention relates to a new family of structurally and functionally related nucleic acids and proteins, designed the CATERPILLER family, which is characterized by landmark structural motifs including a nucleotide binding domain and leucine-rich repeat domains...	11/26/2009
20090233307	METHODS FOR DETECTION OF SINGLE STRAND BREAKS IN DNA Methods are provided for detecting single strand breaks in DNA sample comprising: contacting the DNA with a neutral hydroxylamine, denaturing the DNA and detecting single strand breaks in the denatured DNA. Methods are also provided for the detecting single strand break...	09/17/2009
20090215045	Methods and Compositions for Vitamin K Epoxide Reductase The present invention provides a method of identifying a human subject having increased or decreased sensitivity to warfarin, comprising detecting in the subject the presence of a single nucleotide polymorphism in the VKOR gene, wherein the single nucleotide polymorphis...	08/27/2009
20090081183	HIV Transcription Repressor Complex and Compositions and Methods Based Thereon The molecular mechanism of YY1/LSF-associated repression of HIV-1 is described herein. More particularly, an HIV transcription repressor complex containing YY1, LSF and HDAC1 is described. The invention is based on our discovery that (1) HDAC1 co-purifies with the LTR-b...	03/26/2009
20090035787	ENZYMATIC SYNTHESIS OF SULFATED POLYSACCHARIDES WITHOUT IDURONIC ACID RESIDUES Iduronic acid (IdoUA)-free heparan sulfate (HS)-like compounds are provided. Also provided are methods of synthesizing IdoUA-free HS-like compounds. The methods can include providing at least one O-sulfotransferase (OST) enzyme and a reaction mixture comprising 3′-pho...	02/05/2009
20080293133	Textiles for use in bioreactors for expansion and maintenance of cells A bioreactor for three-dimensional culture of liver cells is disclosed. The device is characterized by the use of textile vasculatures. A model and method for optimizing vasculature parameters is also disclosed. Liver acinar structure and physiological parameters are mi...	11/27/2008
20080234752	Surgical plate puller devices and methods for use with surgical bone screw/plate systems A plate puller device can include a head portion and extension rod portion. The device enables the fastener receiving member to be pulled against a bone surface before a head section of the fastener is advanced within the fastener receiving member into a locked position...	09/25/2008
20080131375	FARNESYLTRANSFERASE INHIBITORS FOR TREATMENT OF LAMINOPATHIES, CELLULAR AGING AND ATHEROSCLEROSIS Although it can be farnesylated, the mutant lamin A protein expressed in Hutchison Gilford Progeria Syndrome (HGPS) cannot be defarnesylated because the characteristic mutation causes deletion of a cleavage site necessary for binding the protease ZMPSTE24 and effecting ...	06/05/2008
20080103489	Vacuum adherent dressings, systems and methods of use for same Vacuum adherent dressings and methods and systems for using the vacuum adherent dressing are disclosed. The vacuum adherent dressing is for wound therapy of a wound having wound edges. The vacuum adherent dressing includes a flexible membrane having a top surface, a bot...	05/01/2008
20080097945	NOVELTY DETECTION SYSTEMS, METHODS AND COMPUTER PROGRAM PRODUCTS FOR REAL-TIME DIAGNOSTICS/PROGNOSTICS IN COMPLEX PHYSICAL SYSTEMS Sensors are configured to repeatedly monitor variables of a physical system during its operation. A novelty detection system is responsive to the sensors and is configured to repeatedly observe into an associative memory, states of associations among the variables that ...	04/24/2008
20080090255	Phosphoprotein detection reagent and method of making and using the same A phosphoprotein detection reagent that selectively binds phosphoamino acids. Methods of generating and employing the reagent are also provided, as are methods of detecting modulation of protein phosphorylation are disclosed. Methods of detecting a change in state of a ...	04/17/2008
20080058372	Synthesis and antimicrobial activity of novel dicationic ''reversed amidines'' The present invention relates to novel 2,5-bis{[alkyl(or aryl)imino]aminophenyl}furans and thiophenes of the general formula in which R₁, R₂, R₃and R₄are each independently selected from the group consisting of H, ...	03/06/2008
20080043920	Micro-focus field emission x-ray sources and related methods Micro-focus field emission x-ray sources and related methods are provided. A micro-focus field emission x-ray source can include a field emission cathode including a film with a layer of electron field emitting materials patterned on a conducting surface. Further, the x...	02/21/2008
20070291896	Systems and methods for detecting an image of an object by use of an X-ray beam having a polychromatic distribution Systems and methods for detecting an image of an object using an X-ray beam having a polychromatic energy distribution are disclosed. According to one aspect, a method can include detecting an image of an object. The method can include generating a first X-ray beam havi...	12/20/2007
20070269866	Methods and compositions for producing vitamin K dependent proteins The present invention relates to methods and compositions for improving the productivity of recombinant vitamin K dependent protein expression in host cells. ...	11/22/2007
20070190614	Methods and compositions for vitamin K epoxide reductase The present invention provides a method of identifying a human subject having increased or decreased sensitivity to warfarin, comprising detecting in the subject the presence of a single nucleotide polymorphism in the VKOR gene, wherein the single nucleotide polymorphis...	08/16/2007
20070114434	MULTI-PIXEL ELECTRON MICROBEAM IRRADIATOR SYSTEMS AND METHODS FOR SELECTIVELY IRRADIATING PREDETERMINED LOCATIONS Multi-pixel electron microbeam irradiator systems and methods are provided with particular applicability for selectively irradiating predetermined cells or cell locations. A multi-pixel electron microbeam irradiator system can include a plurality of individually address...	05/24/2007
20070053489	X-ray imaging systems and methods using temporal digital signal processing for reducing noise and for obtaining multiple images simultaneously X-ray imaging systems and methods are provided that use temporal digital signal processing for reducing noise and for obtaining multiple images simultaneously. An x-ray imaging system can include an x-ray source adapted to generate a pulsed x-ray beam having a predeterm...	03/08/2007
20070038838	Novelty Detection Systems, Methods and Computer Program Products for Real-Time Diagnostics/Prognostics In Complex Physical Systems Sensors are configured to repeatedly monitor variables of a physical system during its operation. A novelty detection system is responsive to the sensors and is configured to repeatedly observe into an associative memory, states of associations among the variables that ...	02/15/2007
20070015270	Crystalline PDE4D2 catalytic domain complex, and methods for making and employing same The presently disclosed subject matter provides a crystalline form of a substantially pure phosphodiesterase 4D2 (PDE4D2) polypeptide. Also provided is a crystalline form of a substantially pure phosphodiesterase 4D2 (PDE4D2) polypeptide in complex with a ligand. Also p...	01/18/2007
20070014148	Methods and systems for attaching a magnetic nanowire to an object and apparatuses formed therefrom Methods and systems are provided for attaching one or magnetic nanowires to an object and apparatuses formed therefrom. An electrophoresis method for attaching one or more nanowires to a sharp tip of an object can include including providing one or more magnetic nanowir...	01/18/2007
20070009950	Methods and compositions for vitamin K epoxide reductase The present invention provides a method of identifying a human subject having increased or decreased sensitivity to warfarin, comprising detecting in the subject the presence of a single nucleotide polymorphism in the VKOR gene, wherein the single nucleotide polymorphis...	01/11/2007
20070009081	Computed tomography system for imaging of human and small animal Computed tomography device comprising an x-ray source and an x-ray detecting unit. The x-ray source comprises a cathode with a plurality of individually programmable electron emitting units that each emit an electron upon an application of an electric field, an anode ta...	01/11/2007
20060223135	High throughput reactive oxygen species-based cytochrome P450 inhibition assay A method of screening a candidate compound for an ability to inhibit a cytochrome P450. The method includes the steps of reacting the candidate compound, an indicator compound precursor, a cytochrome P450 substrate, and the cytochrome P450, the cytochrome P450 character...	10/05/2006
20060142208	Compounds and methods for the treatment of airway diseases and for the delivery of airway drugs Chronic obstructive airway diseases are treated by administering an osmotically active compound such as a salt, sugar, sugar alcohol, or organic osmolyte to the afflicted airway surface. The compound may be administered as a liquid or dry powder aerosol formulation. Dis...	06/29/2006

«First «Previous1 2 Next»Last»

PatentStorm

Quotables

PatentStorm News

Assignee: The University of North Carolina at Chapel Hill