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"I watched his countenance closely, to see if he was not deranged ... and I was assured by other senators after he left the room that they had no confidence in it."
U.S. Senator Smith of Indiana ; After seeing Samuel Morse demonstrate the telegraph.
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| Application No. | Application Title | Issue Date |
| 20130101795 | PHOTOLITHOGRAPHY ON SHRINK FILM Provided are methods of preparing a plurality of extrusions, comprising (a) shrinking a transparent first thermoplastic material comprising a plurality of non-transparent marks, (b) lithographically transferring the pattern of the shrunk non-transparent marks to a layer... | 04/25/2013 |
| 20130086705 | COMPOSITIONS AND METHODS FOR REDUCING AND DETECTING VIRAL INFECTION The invention provides methods and compositions for screening candidate compounds for activity in altering the level of expression of Schlafen (Slfn) in cells, tissues and animals. The invention also provides methods and compositions for screening candidate compounds fo... | 04/04/2013 |
| 20130075373 | High precision, rapid laser hole drilling A laser system produces a first laser beam for rapidly removing the bulk of material in an area to form a ragged hole. The laser system produces a second laser beam for accurately cleaning up the ragged hole so that the final hole has dimensions of high precision.... | 03/28/2013 |
| 20130039991 | Elimination of N-Glycolylneuraminic Acid From Animal Products For Human Use The application is in the field of transgenic (non-human) organisms, sialic acid chemistry, metabolism and antigenicity. More particularly, the invention is related to a method to produce Neu5Gc-free animals and products therefrom comprising disrupting the CMAH gene and... | 02/14/2013 |
| 20130022614 | IgE ANTIBODIES FOR THE TREATMENT OF CANCER The present invention provides monoclonal IgE antibodies comprising Fc epsilon (ε) constant regions and variable regions comprising at least one antigen binding region specific for binding a single epitope of a circulating, tumor-associated antigen (TAA) that is not a ... | 01/24/2013 |
| 20120323501 | FABRIC-BASED PRESSURE SENSOR ARRAYS AND METHODS FOR DATA ANALYSIS A fabric-based pressure sensor array includes: (1) a first layer including M elongated conductive strips coated thereon; (2) a second layer including N elongated conductive strips coated thereon, the M elongated conductive strips extending crosswise relative to the N el... | 12/20/2012 |
| 20120322145 | THREE-DIMENSIONAL CELL ADHESION MATRIX The present invention provides a cell adhesion matrix having poly(vinyl alcohol) chains crosslinked via carboxy phenyl boronic acid crosslinkers. The cell adhesion matrix can also include a molecular recognition element bound to the poly(vinyl alcohol) chains via a carb... | 12/20/2012 |
| 20120315641 | Protein Markers for Lung Cancer Detection and Methods of Using Thereof Disclosed herein are methods, devices and kits for detecting, diagnosing, or categorizing a subject as having lung cancer. As disclosed herein, at least three of the following protein biomarkers: VEGF, CGSF, MIG, RANTES, IL-2, IL-3 and MDC, are used to determine whether... | 12/13/2012 |
| 20120277741 | TISSUE ABLATION WITH IRREVERSIBLE ELECTROPORATION A new method for the ablation of undesirable tissue such as cells of a cancerous or non-cancerous tumor is disclosed. It involves the placement of electrodes into or near the vicinity of the undesirable tissue through the application of electrical pulses causing irrever... | 11/01/2012 |
| 20120275079 | FREQUENCY ADDRESSABLE MICROACTUATORS Frequency addressable micro-actuators having one or more movable resonating elements actuators, such as cantilevers, can be forced into oscillation by, e.g., electromagnetic actuation. The movable structure is designed to latch at a certain amplitude using one of severa... | 11/01/2012 |
| 20120270301 | PROTEINS WITH REPETITIVE BACTERIAL-IG-LIKE (BIG) DOMAINS PRESENT IN LEPTOSPIRA SPECIES The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. Accordi... | 10/25/2012 |
| 20120264649 | AGENTS FOR ENHANCED CHARGE TRANSPORT ACROSS MICROBIAL MEMBRANES The invention provides molecules useful for enhancing charge transport across membranes, such as electron transport across membranes, and methods of using such molecules, for example in improving the performance of a microbial fuel cell or in staining microbes for obser... | 10/18/2012 |
| 20120258488 | Systems and Methods for Electrophysiological Activated Cell Sorting and Cytometry Provided herein are methods and systems for non-genetic, label-free cell purification (i.e., cell cytometry and sorting), which classifies cells based on their spontaneous electrophysiological response or their electrophysiological response to a stimulus. For example, i... | 10/11/2012 |
| 20120230972 | Salinosporamides and Methods for Use Thereof The present invention is based on the discovery that certain fermentation products of the marine actinomycete strains CNB392 and CNB476 are effective inhibitors of hyperproliferative mammalian cells. The CNB392 and CNB476 strains lie within the family Micromonosporaceae... | 09/13/2012 |
| 20120202702 | DETECTION OF LOW CONCENTRATION BIOLOGICAL AGENTS Provided are methods of preparing a sample for detection by placing the sample on a shrinkable scaffold and then shrinking the scaffold. An exemplary shrinkable scaffold is a thermoplastic substrate.... | 08/09/2012 |
| 20120200008 | PREPARATION AND USE OF NANOWRINKLES Provided are methods of preparing a textured surface on a thermoplastic material that include treating the material with a plasma and subsequently shrinking the substrate to induce formation of textures.... | 08/09/2012 |
| 20120184014 | Photoactive Metal Nitrosyls for Blood Pressure Regulation and Cancer Therapy Disclosed are nitric oxide delivery agents and methods of their use, more specifically to photoactive compounds, which are able to perform targeted delivery of nitric oxide in vitro and in vivo and are useful for medicinal applications including, but not limited, to blo... | 07/19/2012 |
| 20120181593 | Semiconductor Device Provided is a semiconductor device that can include a lower interconnection on a substrate and at least one upper interconnection disposed on the lower interconnection. At least one gate structure can be disposed between the upper interconnection and the lower interconn... | 07/19/2012 |
| 20120149710 | SORTASE A INHIBITORS Bacterial infections, including Methicillin resistant Staphylococcus aureus (MRSA) infections are a major health problem that has created a pressing need for new antibiotics. Pyridazinone, rhodanine, and pyrazolethione compounds effective inhibit the enzymatic ac... | 06/14/2012 |
| 20120132278 | LUMINESCENT SOLAR ENERGY CONCENTRATOR An apparatus is disclosed including a wave-guide containing a luminescent material which responds to incident light by emitting frequency-shifted light. A first portion of the frequency-shifted light is internally reflected within the wave-guide to a wave-guide output, ... | 05/31/2012 |
| 20120121639 | PROTEINS WITH REPETITIVE BACTERIAL-IG-LIKE (BIG) DOMAINS PRESENT IN LEPTOSPIRA SPECIES The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. Accordi... | 05/17/2012 |
| 20120116052 | Nucleic Acid Molecules Encoding TNF-Alpha Ligand Polypeptides Having a CD154 Domain The present invention is directed to an isolated polynucleotide sequence encoding a chimeric TNFα, comprising a first nucleotide sequence encoding a domain or subdomain of a tumor necrosis factor ligand other than TNFα, wherein the encoded domain or subdomain replaces... | 05/10/2012 |
| 20120114618 | Mesenchymal Stem Cells Producing Inhibitory RNA for Disease Modification Compositions and methods for delivering a siRNA, dsRNA, or miRNA polynucleotide into a target cell comprising contacting the target cell with a mesenchymal stem cell, which mesenchymal stem cell comprises an exogenous DNA sequence expressing the siRNA or dsRNA polynucle... | 05/10/2012 |
| 20120111397 | KOHLER HOMOGENIZER FOR SOLAR CONCENTRATOR An apparatus is disclosed including: an entrance aperture for admitting light from a source; an optical collector configured to receive light admitted through the entrance aperture and concentrate the light onto a receiver element; and an optical homogenizer element con... | 05/10/2012 |
| 20120097636 | ACOUSTIC SUBSTRATE A micromachined microphone or speaker embedded within, or positioned on top of, a substrate suitable for carrying microelectronic chips and components. The acoustic element converts sound energy into electrical energy which is then amplified by electronic components pos... | 04/26/2012 |
| 20120076763 | COMBINATION ANTI-HIV VECTORS, TARGETING VECTORS, AND METHODS OF USE Recombinant lentiviral vectors containing at least: a lentiviral backbone comprising essential lentiviral sequences for integration into a target cell genome; a nucleic acid encoding a CCR5 RNAi; and an expression control element that regulates expression of the nucleic... | 03/29/2012 |
| 20120064627 | APPARATUS AND METHOD FOR CULTURING STEM CELLS A method is provided to prepare a plurality of microwells suitable for the formation of embryoid bodies from embryonic stem cells. The method requires applying an image-forming material to a heat sensitive thermoplastic material in a designed pattern and heating the mat... | 03/15/2012 |
| 20120064581 | ESCHERICHIA COLI METABOLIC ENGINEERING OXYGEN INDEPENDENT PLATFORM STRAINS AND METHODS OF USE THEREOF The invention provides transgenic Escherichia coli cells comprising a mutation in cydAB gene, and/or cyoABCD gene, and/or cbdAB gene, and/or ygiN gene, wherein the mutation reduces (preferably, but not necessarily, by 100%) the cytochrome oxydase activity of a pr... | 03/15/2012 |
| 20120064040 | SERUM FREE CULTURE MEDIUM AND SUPPLEMENT Provided herein is a chemically defined method of endothelial cell (EC) derivation from embryonic stem cells (ESC). These progenitor cells are capable of low-density lipoprotein uptake, an important function of EC, and also express EC specific markers. By using chemical... | 03/15/2012 |
| 20120058975 | Phosphonate Compounds The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the li... | 03/08/2012 |
| 20120057819 | PHOTONIC DEVICES HAVING DEGENERATE OR SPLIT SPECTRAL BAND EDGES AND METHODS FOR USING THE SAME Provided herein are photonic devices configured to display photonic band gap structure with a degenerate or a split band edge. Electromagnetic radiation incident upon these photonic devices can be converted into a frozen mode characterized by a significantly increased a... | 03/08/2012 |
| 20120129209 | ALIGNING CELLS ON WRINKLED SURFACE A method is provided for preparing an aligned cell population comprising the culturing one or more cells on a surface having a texture, which texture has an average height of from about 100 nanometers to about 5 micrometers, thereby forming an aligned cell population on... | 05/24/2012 |
| 20120105099 | Homogeneous Dual-Rail Logic for DPA Attack Resistive Secure Circuit Design Homogenous dual-rail logic for DPA attack resistive secure circuit design is disclosed. According to one embodiment, an HDRL circuit comprises a primary cell and a complementary cell, wherein the complementary cell is an identical duplicate of the primary cell. The HDRL... | 05/03/2012 |
| 20120103768 | Magnetically Actuated Micro-Electro-Mechanical Capacitor Switches in Laminate Magnetically actuated micro-electro-mechanical capacitor switches in laminate are disclosed. According to one embodiment, an apparatus comprises a first layer comprising a coil and magnetic element, the magnetic element made from one of nickel and iron; a second layer c... | 05/03/2012 |
| 20120082675 | INSULIN-LIKE GROWTH FACTOR SIGNALING AND INTEGRIN Interaction between insulin-like growth factor 1 (IGFI) and integrin is involved in integrin-mediated cellular signaling, such as enhanced proliferation of cells expressing integrins, especially integrin alpha v beta 3, alpha 6 beta. 1 and alpha 6. beta. 4. A method for... | 04/05/2012 |
| 20120080026 | APPARATUS AND METHOD FOR SOLAR THERMAL ENERGY COLLECTION An apparatus for collecting solar energy includes a receptacle adapted for receiving solar thermal energy; an insert located within the receptacle, the insert being a heat pipe adapted to transfer heat; and an absorption device positioned proximate to and substantially ... | 04/05/2012 |
| 20120071874 | TISSUE ABLATION WITH IRREVERSIBLE ELECTROPORATION A new method for the ablation of undesirable tissue such as cells of a cancerous or non-cancerous tumor is disclosed. It involves the placement of electrodes into or near the vicinity of the undesirable tissue through the application of electrical pulses causing irrever... | 03/22/2012 |
| 20120038249 | NOVEL RESPONSIVE POLYMER SYSTEM AND NANOHYBRID THIN FILMS This disclosure discloses novel responsive polymers that comprise a rod segment and (or) a coil segment. This disclosure also discloses nanomaterial-polymer composite comprising the responsive polymers that are covalently linked with nanomaterials. Also disclosed are po... | 02/16/2012 |
| 20120027151 | INDUCTIVE PLASMA SOURCE AND PLASMA CONTAINMENT A system and apparatus for controlled fusion in a field reversed configuration (FRC) magnetic topology and conversion of fusion product energies directly to electric power. Preferably, plasma ions are magnetically confined in the FRC while plasma electrons are electrost... | 02/02/2012 |
| 20120021522 | Method for the Evolutionary Design of Biochemical Reaction Networks The present invention relates to methods for achieving an optimal function of a biochemical reaction network. The methods can be performed in silico using a reconstruction of a biochemical reaction network of a cell and iterative optimization procedures. The methods can... | 01/26/2012 |
