Assignee: The Curators of the University of Missouri

Location: Not specified.
No. of applications: 32

Application No.	Application Title	Issue Date
20110105417	Drug Conjugates Conjugated compounds comprising a therapeutic or diagnostic agent linked to a substrate for a cell membrane transporter or receptor by lipophilic linker are provided....	05/05/2011
20100317013	METHODS AND COMPOSITIONS FOR DETECTING SPERMATOZOA OR SEMEN IN A SAMPLE The present invention concerns compositions and methods for evaluating fertility in humans and animals. The invention may also be used to identify reproductive cancers such as testicular cancer. In various embodiments of the invention, an Sptrx-3 enzyme is used as a fer...	12/16/2010
20100221707	DIAGNOSTIC METHODS FOR DETECTING CONGENITAL BONE DEFECTS The present disclosure is directed to compositions and methods for screening for patients at risk for autosomal recessive hypophosphatemic rickets. More particularly, diagnostic reagents and procedures are provided for analyzing samples to detect defective DMP1 expressi...	09/02/2010
20080200644	Method for inverse solid phase synthesis of peptides The present invention provides a process for preparing a peptide of formula (I): Sub-[L]-[NH-A-C(O)]_n+m—OH (I) comprising: 08/21/2008
20080152899	Reducing electrostatic discharge ignition sensitivity of MIC materials The invention provides metastable intermolecular composites that have good thermite properties while also being relatively insensitive to electrostatic discharge ignition. A preferred embodiment metastable intermolecular composite has a metal oxide nanostructure, which ...	06/26/2008
20080129316	NON-DESTRUCTIVE TESTING OF PHYSICAL CHARACTERISTICS OF COMPOSITE STRUCTURES A method for detecting an anomaly in a composite material comprising directing two transmitted electromagnetic wave signals orthogonally polarized with respect to each other from a probe to the composite material, wherein the probe and composite material are positioned ...	06/05/2008
20080070964	OPIOID RECEPTOR ACTIVE COMPOUNDS The invention provides compounds of formula I: wherein R¹to R⁴and n have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a ...	03/20/2008
20080039612	ATTACHMENT AND ELABORATION STRATEGIES FOR INVERSE PEPTIDE SYNTHESIS The present invention provides a process for preparing a peptide of formula (I): Sub-[L]-[N(R¹)-A-C(O)]_p—[NH-A-C(O)]_n+m—OH (I) comprising: (a) reacting an immobilized compound of formula (...	02/14/2008
20070142302	PEPTIDYL PRODRUGS THAT RESIST P-GLYCOPROTEIN MEDIATED DRUG EFFLUX A method of treating a patient for a condition wherein the bioactive agent of choice is DRUG, wherein DRUG is a substrate that is effluxed by the P-gp transporter, is provided, the method comprising administering to the patient an effective amount of a compound of formu...	06/21/2007
20070099335	On-chip igniter and method of manufacture A chip for igniting nanoenergetic materials, includes a substrate, an igniter positioned on the substrate and the nanoenergetic material arranged in a linear pattern positioned on said substrate. A method of making a chip for igniting nanoenergetic materials includes pr...	05/03/2007
20070095445	Ordered nanoenergetic composites and synthesis method A structured, self-assembled nanoenergetic material is disclosed that includes a nanostructure comprising at least one of the group consisting of a fuel and an oxidizer and a plurality of substantially spherical nanoparticles comprising at least the other of the group c...	05/03/2007
20070051202	Methods and articles for gold nanoparticle production An example embodiment of a method for making gold nanoparticles includes steps of reacting a gold salt with a phosphino amino acid. Example phosphino amino acids include trimers, with a particular example being a trimeric amino acid conjugate containing one phosphino gr...	03/08/2007
20070023037	Focused droplet nebulizer for evaporative light scattering detector A focused droplet nebulizer of the invention produces substantially uniform droplets of a predetermined size. Droplets are pushed out through a small outlet orifice by the contraction of a chamber. The droplets can be carried on a substantially non-divergent path in a d...	02/01/2007
20060280340	Conjunctival scans for personal identification Conjunctival vascular images are obtained from individual's eye for purposes of creating a multi-dimension, non-iris based biometric. The biometric can be used for identification or authentication purposes. Multi-dimensional correlation processing can be used to evaluat...	12/14/2006
20060212279	Methods for efficient solution set optimization A method for optimizing a solution set comprises the steps of generating an initial solution set, identifying a desirable portion of the initial solution set using a fitness calculator, using the desirable portion to create a surrogate fitness model that is computationa...	09/21/2006
20060199235	Compositions and method for accurate early pregnancy diagnosis The invention provides improved assays for detection of pregnancy. In the assays, pregnancy associated glycoproteins are analyzed in conjunction with progesterone analysis. The techniques of the invention overcome limitations in the prior art by reducing the rate of fal...	09/07/2006
20060152726	Ultrasensitive spectrophotometer The invention concerns measurements in which light interacts with matter giving rise to changes in light intensity, and preferred embodiment spectrophotometer devices of the invention provide for ultrasensitive measurements through a reflection interaction with matter. ...	07/13/2006
20060139317	Virtual environment navigation device and system An impact platform device for use with a virtual reality interface system that promotes navigation by a user in a virtual environment, the platform device including a platform being configured to receive impacts from the user, an odd-numbered plurality of sensors evenly...	06/29/2006
20060128776	Opioid receptor active compounds The invention provides compounds of formula I: wherein R¹to R⁴and n have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a ...	06/15/2006
20060086197	Strain sensitive coax cable sensors for monitoring structures The invention provides increased structural monitoring systems that have sensitive continuous coaxial cable sensors. A preferred embodiment sensor cable of the invention includes an inner conductor, a dielectric jacket, and an outer conductor that is configured to passi...	04/27/2006
20060079001	Local flow and shear stress sensor based on molecular rotors A method for detecting local shear stress values using molecular rotors that allows for an extremely sensitive determination of a shear stress field or a flow field, even at very low flow rates. In one embodiment, molecular rotors may be adhered to a fiber optic probe o...	04/13/2006
20060072186	Microwave frequency electro-optical beam deflector and analog to digital conversion The phase velocity of an optical wave is effectively reduced to that of a microwave frequency electromagnetic signal in this optical deflector. The electro-optic effect is used for a controlled deflection of an optical beam. The angle of beam deflection varies in accord...	04/06/2006
20060063880	Transparent composites and laminates and methods for making An exemplary method for making a transparent composite includes steps of combining a refractive index modifier with a precursor solution, combining glass with the precursor solution, and curing the precursor solution to create a transparent glass reinforced polymer comp...	03/23/2006
20060045916	Methods for producing silver nanoparticles An exemplary embodiment of the invention is a method for making silver nanoparticles, and includes steps of reacting a silver salt with a phosphene amino acid to make silver nanoparticles. Exemplary phosphene amino acids include trimers, with a particular example being ...	03/02/2006
20060039257	Method and apparatus for nondestructive sample inspection An apparatus for inspecting a sample for defects includes a signal generator for generating a signal and a device for splitting the signal into two separate signals which have substantially equal phase and magnitude. A sensor radiates the two signals on the sample and r...	02/23/2006
20060008907	Control of gene expression via light activated RNA interference A method for controlling the spacing, timing and degree of gene expression that includes selecting a target mRNA, obtaining siRNA corresponding to the target mRNA, modifying the siRNA with a photo-labile group to inhibit RNA interference, introducing the modified siRNA ...	01/12/2006
20050282191	Methods and compositions for evaluation of fertility The present invention concerns compositions and methods for evaluating fertility in humans and animals. The invention may also be used to identify reproductive cancers such as testicular cancer. In various embodiments of the invention, an Sptrx-3 enzyme is used as a fer...	12/22/2005
20050179904	Light scattering detector The invention concerns high sensitivity light scattering detection and its application to evaporative light scattering detection in liquid chromatography. The exemplary embodiment includes a detection cell to accept particles suspended in a gas stream and permit a polar...	08/18/2005
20050074448	Method of treatment of endothelial dysfunction and engineered proteins for same Endothelial cells produce many factors that are involved in maintaining blood vessels. One of the best understood and most studied factor is nitric oxide (NO), which is produced by an endothelial enzyme called nitric oxide synthase (eNOS). The present invention provides...	04/07/2005
20050043806	Elbow arthroplasty system A prosthetic elbow for replacing an elbow of a dog or a human to restore normal, pain-free joint function. The elbow includes a humeral component for attachment to a humerus and a radioulnar component for attachment to an ulna. The humeral component includes a generally...	02/24/2005
20050043246	Acyclovir-peptide analogs Dipeptide and tripeptide ester derivatives of acyclovir and its analogs are disclosed which are useful to treat herpes virus infections. Also disclosed is a method for preparing a therapeutic agent for targeted delivery to ocular tissue comprising linking the therapeuti...	02/24/2005
20050037972	Phage-display peptides as novel antimicrobial agents against haemophilus influenzae Whole cell phage-display techniques were used to identify several peptides that bound preferentially to a non-typeable strain of Haemophilus influenzae. These peptides were able to inhibit growth of both H. influenzae and Staphylococcal aureus. Thus...	02/17/2005

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Assignee: The Curators of the University of Missouri