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| Application No. | Application Title | Issue Date |
| 20120015434 | EXPANSION OF NK CELLS AND THERAPEUTIC USES THEREOF The present invention relates to novel methods for preferentially activating and expanding NK cells. The methods utilize the stimulatory effects of IL-15 and CD137 ligand to preferentially expand and activate NK cells in a mixed cell culture comprising NK cells.... | 01/19/2012 |
| 20110287532 | EXPRESSION OF FACTOR IX IN GENE THERAPY VECTORS Two mechanisms are provided for improving the expression of Factor IX in gene therapy vectors. The first is the use of a specific Factor IX polynucleotide coding sequence designed for optimal expression. The second is the use of transcriptional regulatory regions minimi... | 11/24/2011 |
| 20110256546 | METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF CANCER RESISTANT TO ANAPLASTIC LYMPHOMA KINASE (ALK) KINASE INHIBITORS Compositions and methods for the diagnosis and treatment of a cancer that is resistant to at least one anaplastic lymphoma kinase (ALK) kinase inhibitor are provided herein. The present invention is based on the discovery of mutations within ALK that confer resistance t... | 10/20/2011 |
| 20110165141 | Compositions for treating bacterial infections Polynucleotides encoding a mutant human carboxylesterase enzyme and polypeptides encoded by the polynucleotides which are capable of metabolizing a prodrug and inactive metabolites thereof to active drug are provided. Compositions and methods for sensitizing cells to a ... | 07/07/2011 |
| 20110104202 | Modified Influenza Virus For Monitoring And Improving Vaccine Efficiency The immunogenicity of the influenza virus hemagglutinin (HA) molecule may be increased by substitutions of amino acids in the HA sequence. The substitution of specific HA residues, such as asparagine at position 223 of H5 HA, increase the sensitivity of the hemagglutini... | 05/05/2011 |
| 20100240057 | METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF CHRONIC MYELOID LEUKEMIA AND ACUTE LYMPHOBLASTIC LEUKEMIA Compositions and methods for the identification, prognosis, classification, treatment, and diagnosis of leukemia or a genetic predisposition to leukemia are provided. The present invention is based on the discovery of various genomic abnormalities of the IKZFl gene whic... | 09/23/2010 |
| 20100150941 | HEMAGGLUTININ ANTIBODY AND USES THEREOF Passive antibody therapy as a tool for both prophylaxis against—and treatment of—highly pathogenic H5N1 influenza virus, providing immediate immunity is described. It is provided by an antibody specific to hemagglutinin capable of neutralizing influenza viruses and ... | 06/17/2010 |
| 20100143394 | SYNTHETIC STREPTOCOCCUS PNEUMONIAE VACCINE Compositions and methods for preventing and treating pneumococcal infections are provided. Compositions include novel polypeptides comprising an amino acid sequence corresponding to the R2i or R22 domain of CbpA or a consensus sequence of one of these domains, an... | 06/10/2010 |
| 20100099105 | ANTIBODIES HAVING BINDING SPECIFICITY FOR THE EXTRACELLULAR DOMAIN OF A BREAST CANCER RESISTANCE PROTEIN (BCRP) The present invention includes methods of identifying and/or isolating stem cells based on expression of BCRP. The present invention also describes methods of obtaining and/or using cell populations enriched for stem cells. In addition, methods are provided for diagnosi... | 04/22/2010 |
| 20100047179 | TARGETED SPLIT BIOMOLECULAR CONJUGATES FOR THE TREATMENT OF DISEASES, MALIGNANCIES AND DISORDERS, AND METHODS OF THEIR PRODUCTION The present invention is directed to compositions and methods for the production of split-biomolecular conjugates for the directed targeting of nucleic acids and polypeptides. More preferably, the compositions and methods allow for the use of the split biomolecular conj... | 02/25/2010 |
| 20100035764 | METHODS AND COMPOSITIONS FOR MONITORING T CELL RECEPTOR DIVERSITY The present invention provides an array for use in a method of monitoring T cell diversity. The array comprises a substrate having a plurality of capture probes that can specifically bind to a nucleic acid molecule corresponding to a T cell receptor (TCR) gene family se... | 02/11/2010 |
| 20090226473 | LYMPHOCYTE SURFACE RECEPTOR THAT BINDS CAML AND METHODS OF USE THEREOF A novel lymphocyte receptor protein, its DNA sequence, and its role in the calcium activation pathway is described. The protein, or genetically engineered constructs encoding it, is shown to increase lymphocyte response, and to identify ligands of the protein receptor. ... | 09/10/2009 |
| 20090149377 | METHODS FOR REGULATION OF p53 TRANSLATION AND FUNCTION The present invention relates to novel methods for modulating the activity of p53 tumor suppressor protein by affecting p53 translational regulation. More specifically, the invention relates to novel methods for modulating p53 mRNA translation in a cell by affecting a f... | 06/11/2009 |
| 20090099134 | TREATMENT OF DNA DAMAGE RELATED DISORDERS The present invention provides methods and compositions for prophylaxis and treatment of a variety of disorders including DNA damage related disorders, cancer, ischemia, oxidative stress, atherosclerosis, and stroke using a chloroquine compound.... | 04/16/2009 |
| 20090011498 | EXPANSION OF NK CELLS AND THERAPEUTIC USES THEREOF The present invention relates to novel methods for preferentially activating and expanding NK cells. The methods utilize the stimulatory effects of IL-15 and CD137 ligand to preferentially expand and activate NK cells in a mixed cell culture comprising NK cells.... | 01/08/2009 |
| 20090010962 | Genetically Engineered Swine Influenza Virus and Uses Thereof The present invention relates, in general, to attenuated swine influenza viruses having an impaired ability to antagonize the cellular interferon (IFN) response, and the use of such attenuated viruses in vaccine and pharmaceutical formulations. In particular, the invent... | 01/08/2009 |
| 20090004173 | Diagnosis and Treatment of Drug Resistant Leukemia The present invention encompasses methods and compositions useful in the diagnosis and treatment of drug resistant leukemia. The invention provides a number of genes that are differentially expressed between drug resistant and drug sensitive acute lymphoblastic leukemia... | 01/01/2009 |
| 20080319010 | Use of Chloroquine to Treat Metabolic Syndrome The present invention provides methods and compositions for modulating certain metabolic processes and for treating a variety of disorders associated with metabolic syndrome, including insulin related disorders, ischemia, oxidative stress, atherosclerosis, hypertension,... | 12/25/2008 |
| 20080311149 | DNA-transfection system for the generation of infectious influenza virus The present invention is based on the development of a dual promoter system (preferably a RNA pol I-pol II system) for the efficient intracellular synthesis of viral RNA. The resultant minimal plasmid-based system may be used to synthesize any RNA virus, preferably viru... | 12/18/2008 |
| 20080311148 | DNA-transfection system for the generation of infectious influenza virus The present invention is based on the development of a dual promoter system (preferably a RNA pol I-pol II system) for the efficient intracellular synthesis of viral RNA. The resultant minimal plasmid-based system may be used to synthesize any RNA virus, preferably viru... | 12/18/2008 |
