Assignee: SRU Biosystems, Inc.

Location: Not specified.
No. of applications: 36

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Application No.	Application Title	Issue Date
20120040866	High Resolution Label Free Analysis of Cellular Properties The invention provides methods of detecting a change in cell growth patterns....	02/16/2012
20110237535	Use of Induced Pluripotent Cells and other Cells for Screening Compound Libraries The invention provides methods for screening test compounds or toxins for effects on cells. The invention also provides methods for determining frequency, amplitude and kinetic profiles of cells....	09/29/2011
20110237464	Guided Mode Resonant Filter Biosensor Using a Linear Grating Surface Structure Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters....	09/29/2011
20110201132	Optical Detection of Label-Free Biomolecular Interactions using Microreplicated Plastic Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters....	08/18/2011
20100329933	Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor A grating-based sensor is disclosed that has a grating structure constructed and designed for both evanescent resonance (ER) fluorescence detection and label-free detection applications. Some embodiments are disclosed which are optimized for ER detection in an air mode,...	12/30/2010
20100291575	Detection of Changes in Cell Populations and Mixed Cell Populations The invention provides methods of label-free detection of changes in cell populations and mixed cell populations....	11/18/2010
20100273185	Detection of Biased Agonist Activation The invention provides single assay methods to detect the activity of biased agonists or agonists that are less than full agonists on cells....	10/28/2010
20100227769	GRATING-BASED SENSOR COMBINING LABEL-FREE BINDING DETECTION AND FLUORESCENCE AMPLIFICATION AND READOUT SYSTEM FOR SENSOR A grating-based sensor is disclosed that has a grating structure constructed and designed for both evanescent resonance (ER) fluorescence detection and label-free detection applications. Some embodiments are disclosed which are optimized for ER detection in an air mode,...	09/09/2010
20100202923	Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor A grating-based sensor is disclosed that has a grating structure constructed and designed for both evanescent resonance (ER) fluorescence detection and label-free detection applications. One and two-dimensional gratings are also disclosed, including gratings characteriz...	08/12/2010
20100043571	Simultaneous aspirator and dispenser for multiwell plates and similar devices A device for simultaneously dispensing a solution containing a sample to a test device and aspirating the sample from the device. In one embodiment the device is hand-held and includes a control mechanism, e.g., button for activating the dispensing and aspiration of the...	02/25/2010
20100015721	Detection of Promiscuous Small Submicrometer Aggregates The invention provides methods for the detection of aggregating molecules that are capable of promiscuous or non-specific binding to proteins in a time efficient manner without the use of labels....	01/21/2010
20100008826	Biosensors featuring confinement of deposited material and intra-well self-referencing A test device includes one or more sample wells and a biosensor placed in the well. The biosensor includes structural features promoting confinement of a deposited material, e.g., surface chemistry material, to stay within a specified predetermined area in the well. The...	01/14/2010
20100003743	Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor A grating-based sensor is disclosed that has a grating structure constructed and designed for both evanescent resonance (ER) fluorescence detection and label-free detection applications. Some embodiments are disclosed which are optimized for ER detection in an air mode,...	01/07/2010
20090305304	High Resolution Label Free Analysis of Cellular Properties The invention provides methods of detecting a change in cell growth patterns....	12/10/2009
20090282931	Simultaneous aspirator and dispenser for multiwell plates and similar devices A method of making a measurement of binding affinity of a sample comprises the steps of: introducing the sample into a well having a bottom formed as a photonic crystal biosensor, wherein a portion of the sample becomes bound to the biosensor; making a measurement of th...	11/19/2009
20090264314	Optical Detection of Label-Free Biomolecular Interactions Using Microreplicated Plastic Sensor Elements Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters....	10/22/2009
20090226950	Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor A grating-based sensor is disclosed that has a grating structure constructed and designed for both evanescent resonance (ER) fluorescence detection and label-free detection applications. One and two-dimensional gratings are also disclosed, including gratings characteriz...	09/10/2009
20090192049	Proteolipid Membrane and Lipid Membrane Biosensor The invention provides compositions and methods for detection of interaction of molecules....	07/30/2009
20090176658	Real Time Binding Analysis of Antigens on a Biosensor Surface The invention provides methods for detecting interactions between phage and antigen or antigen and antibody using biosensors....	07/09/2009
20090148955	Label-Free High-Throughput Optical Technique for Detecting Biomolecular Interactions Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters....	06/11/2009
20090137422	Methods for Identifying Modulators of Ion Channels The invention provides methods for identifying modulators of ion channels without the use of recombinant cell lines over-expressing the ion channel proteins or the use of detection labels....	05/28/2009
20080299673	Method for Employing a Biosensor to Detect Small Molecules ("Fragments") that Bind Directly to Immobilized Protein Targets The invention provides method of detecting interactions of small molecules with target molecules....	12/04/2008
20080219892	Guided Mode Resonant Filter Biosensor Using a Linear Grating Surface Structure Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters....	09/11/2008
20080219615	Photonic crystal sensors with intergrated fluid containment structure Photonic crystal (PC) sensors, and sensor arrays and sensing systems incorporating PC sensors are described which have integrated fluid containment and/or fluid handling structures. Sensors and sensing systems of the present disclosure are capable of high throughput sen...	09/11/2008
20080115567	Simultaneous aspirator and dispenser for multiwell plates and similar devices A device for simultaneously dispensing a solution containing a sample to a test device and aspirating the sample from the device. In one embodiment the device is hand-held and includes a control mechanism, e.g., button for activating the dispensing and aspiration of the...	05/22/2008
20080103056	Label-Free Methods for Performing Assays Using a Colorimetric Resonant Reflectance Optical Biosensor The instant invention provides compositions and methods for determining cell interactions that are faster than conventional methods and that require the use of fewer reagents than conventional methods. ...	05/01/2008
20080014632	Near ultraviolet-wavelength photonic-crystal biosensor with enhanced surface to bulk sensitivity ratio Biosensors are disclosed based on one- or two-dimensional photonic-crystal reflectance filters operating at near-ultraviolet wavelengths. Rigorous Coupled-Wave Analysis simulations predict a more tightly confined resonant electric field at the surface of this biosensor ...	01/17/2008
20070054339	Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor Methods are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also relates to optical devices. ...	03/08/2007
20070047874	Optimized grating based biosensor and substrate combination A grating-based biosensor is disclosed where the biosensor is constructed and arranged such that the grating lines of the sensor align with an optical axis of a birefringent substrate, so as to improve resonance peak uniformity. Methods of manufacturing biosensors to pr...	03/01/2007
20070009380	Photonic crystal biosensor structure and fabrication method The invention provides sensor compositions and method of making sensors. ...	01/11/2007
20060291779	Optimized grating based biosensor and substrate combination A grating-based biosensor is disclosed where the biosensor is constructed and arranged such that the grating lines of the sensor align with an optical axis of a birefringent substrate, so as to improve resonance peak uniformity. Methods of manufacturing biosensors to pr...	12/28/2006
20060291766	Biosensor substrate structure for reducing the effects of optical interference A biosensor substrate structure is provided that eliminates the effects of optical interference of light reflected from a substrate/air interface with light reflected by the biosensor's active surface by incorporating a roughened or “non-specular” surface on the low...	12/28/2006
20060281077	Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor Methods are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also relates to optical devices. ...	12/14/2006
20060275825	Proteolipid membrane and lipid membrane biosensor The invention provides compositions and methods for detection of interaction of molecules. ...	12/07/2006
20060148100	Real time binding analysis of antigens on a biosensor surface The invention provides methods for detecting interactions between phage and antigen or antigen and antibody using biosensors. ...	07/06/2006
20060030033	Label-free high-throughput optical technique for detecting biomolecular interactions Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters. ...	02/09/2006

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Assignee: SRU Biosystems, Inc.