William F. Semple, a dentist, was awarded the first US Patent on chewing gum in 1869. His recipe contained powdered chalk.
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| Application No. | Application Title | Issue Date |
| 20120040464 | METHOD FOR GENERATING HOMOPLASMIC CELLS FROM HETEROPLASMIC CELLS It is an object of the present invention to provide a method, which comprises allowing a eukaryotic cell to come into contact with a reactive oxygen species or a chemical species that generates such a reactive oxygen species in the cell, and thereby changing the percent... | 02/16/2012 |
| 20120034643 | FLUORESCENT PROTEIN An object of the present invention is to provide a red or orange fluorescent protein, which is characterized in that the difference (stokes shift) between an excitation peak value (wavelength of maximum absorption) and a fluorescence peak value (wavelength of maximum fl... | 02/09/2012 |
| 20110269945 | FLUORESCENT PROTEIN An object of the present invention is to provide a novel fluorescent protein derived from favia favus. The present invention provides a fluorescent protein derived from favia favus having the following properties: 11/03/2011 | |
| 20110301043 | RISK ASSESSMENT FOR CUTANEOUS ADVERSE DRUG REACTIONS FROM ANTIRETROVIRAL AGENT The present invention provides a method of predicting the risk of a patient for developing cutaneous adverse drug reaction to non-nucleoside reverse transcriptase inhibitors such as nevirapine by using HLA-B*3505 allele and/or polymorphisms in the CCHCR1 gene.... | 12/08/2011 |
| 20110258737 | RICE GENE CAPABLE OF IMPARTING WIDE-SPECTRUM DISEASE RESISTANCE A three-step screening of selection for resistance against pathogenic bacteria infection, selection for resistance against pathogenic fungi infection, and selection for sensitivity to salicylic acid was carried out on Arabidopsis thaliana lines highly expressing ... | 10/20/2011 |
| 20110243910 | MAMMALIAN RNA DEPENDENT RNA POLYMERASE The invention provides compositions comprising a TERT-RMRP or TERT-RNA complex and methods of treating subjects with genetic diseases in which gene silencing is either increased by administering the compositions of the invention or decreased by administering an inhibito... | 10/06/2011 |
| 20110236900 | NOVEL MUTS PROTEIN AND METHOD FOR DETERMING MUTATION USING THE SAME A method for determining the presence or absence of a mutation on the basis of the presence or absence of amplification with high reliability is provided. A target sequence including a target site contained in a sample nucleic acid is amplified using a primer that can h... | 09/29/2011 |
| 20110223636 | FLUORESCENT PROTEIN AND CHROMOPROTEIN It is an object of the present invention to provide a novel fluorescent protein and a novel chromoprotein. The present invention provides a novel fluorescent protein derived from Montipora sp., Acropora sp. and Lobophytum crassum, and a novel chromo... | 09/15/2011 |
| 20110216312 | SEMICONDUCTOR INSPECTION DEVICE AND INSPECTION METHOD For a semiconductor device S, an inspection is performed in a zero-bias state by use of electromagnetic waves generated by irradiation of pulsed laser light, and an inspection range is set with reference to layout information of the semiconductor device S to perform two... | 09/08/2011 |
| 20110196415 | MATERIAL FOR ANEURYSM CURING It is an object of the present invention to provide a polymer material, the histocompatibility of which has been improved by irradiation of ion beam, which prevents an aneurysm having a risk of rupture from actually rupturing. The present invention provides a material f... | 08/11/2011 |
| 20110179521 | PLANT SHOWING RESISTANCE TO MULTIPLE DISEASES AND METHOD FOR PRODUCING THE SAME It is found that multiple different resistance genes adjacent to each other on the genome of Arabidopsis recognize attacks from multiple different pathogens and activate the resistance reactions. Introduction of a combination of multiple different resistance gene... | 07/21/2011 |
| 20110152502 | FLUORESCENT PROTEIN The object of the present invention is to provide a novel fluorescent protein in which on and off of fluorescence thereof can be controlled by irradiation with lights of two different wavelengths. The present invention provides a fluorescent protein shown in the followi... | 06/23/2011 |
| 20110129826 | METHOD FOR DETERMINATION OF INFLAMMATORY DISEASE BY USING SINGLE NUCLEOTIDE POLYMORPHISM IN BRCA1-RELATED PROTEIN (BRAP) GENE It is an object of the present invention to identify a novel single nucleotide polymorphism (SNP) associated with the development and advancement of inflammatory diseases such as myocardial infarction. The present invention provides a method for judging inflammatory dis... | 06/02/2011 |
| 20110111446 | THIOL DETECTION METHOD It is an object of the present invention to provide: a novel thiol-detecting reagent, which can be used in vivo and which solves the problem regarding the generation of background fluorescence due to hydrolysis; and a method for detecting thiol using the aforementioned ... | 05/12/2011 |
| 20110076680 | FLUORESCENT MOLECULE It is an object of the present invention to provide an on-off type fluorescent compound (a fluorescence-producing molecule system) used in gene analyses, which is highly stable (namely, being active for a long period of time) and highly sensitive, and which enables ampl... | 03/31/2011 |
| 20110071278 | ANTIBODIES THAT RECOGNIZE CUTTING EDGE WITHIN THE TGF- BETA ACTIVATION CONTROLLING REGION It is an object of the present invention to provide antibodies capable of detecting an active TGF-β generation reaction that is specific to pathogenesis, tissues, or isoforms. The present invention provides antibodies against an LAP fragment (or latent TGF-β) generate... | 03/24/2011 |
| 20110065102 | OSTEOARTHRITIS-SENSITIVE GENE It is an object of the present invention to provide a method and kit for diagnosing osteoarthritis which involves genetic diagnosis or hemodiagnosis. The present invention provides a method for diagnosing a genetic susceptibility of a subject to osteoarthritis, which co... | 03/17/2011 |
| 20110058155 | MOBILITY MEASURING APPARATUS, METHOD THEREFOR, AND RESISTIVITY MEASURING APPARATUS AND METHOD THEREFOR A mobility measuring apparatus includes a storage unit that respectively stores a relationship between the mobility μ of carriers in a semiconductor and a decay constant γ of the carriers and a relationship between a reflectivity R of the semiconductor to a terahertz ... | 03/10/2011 |
| 20110057109 | MONOCHROMATIC WAVELENGTH VARIABLE TERAHERTZ WAVE GENERATION/DETECTION SYSTEM AND METHOD To provide a monochromatic wavelength variable terahertz wave generation/detection system that has high detection sensitivity at room temperature and that can quickly operate at the same time, excitation light of monochromatic wavelength generated from one excitation li... | 03/10/2011 |
| 20110039912 | Therapeutic Agent for Neuroblastoma Targeting ARID3b It is intended to provide a therapeutic agent for neuroblastoma. More particularly, it is intended to provide the therapeutic agent for neuroblastoma containing an ARID3b inhibitor.... | 02/17/2011 |
| 20110038032 | TERAHERTZ WAVE GENERATING METHOD AND APPARATUS A first laser beam 1a and a second laser beam 1b are incident on a difference frequency mixing unit, and the two laser beams are overlapped in the difference frequency mixing unit, thereby generating a terahertz wave whose frequency is a frequency differen... | 02/17/2011 |
| 20110037001 | TERAHERTZ BEAM SCANNING APPARATUS AND METHOD THEREOF To provide a terahertz beam scanning apparatus and method that can scan a terahertz beam at high speed over a wide angle. The terahertz beam scanning apparatus includes: a laser device 12 that generates a first laser beam 1 and a second laser beam 2... | 02/17/2011 |
| 20110004240 | VISIBLE LIGHT CURABLE ADHESIVE An object of the present invention is to provide a water soluble bioadhesive that is curable by visible light irradiation. The present invention provides a visible light curable adhesive, which comprises a water soluble oxygen sensitizer that generates radicals under vi... | 01/06/2011 |
| 20100323346 | Method of Examining Inflammatory Disease and Method of Screening Remedy for Inflammatory Disease A single nucleotide polymorphism occurring on a leptin receptor gene is analyzed and an inflammatory disease is examined on the basis of the analytical data. Further, a substance capable of changing the interaction between the leptin receptor and galectin-2 is selected ... | 12/23/2010 |
| 20100312375 | ARTIFICIAL BONE FORMING METHOD BY POWDER LAMINATION METHOD An artificial bone forming method, comprising a) a powder layer forming step (32) for forming, into a flat powder layer (6), a powder bone material (5) having biocompatibility and hardening by hydration, b) a partial hardening step (34) for j... | 12/09/2010 |
| 20100311608 | METHOD TO PREPARE MAGNETIC BEADS CONJUGATED WITH SMALL COMPOUNDS It is an object of the present invention to provide a method for stably and efficiently binding a compound to magnetic beads. The present invention relates to a method for producing compound-bound magnetic beads, which comprises: allowing a compound to come into contact... | 12/09/2010 |
| 20100304497 | FLUORESCENT PROTEIN AND CHROMOPROTEIN It is an object of the present invention to provide a novel chromoprotein and a novel fluorescent protein. The present invention provides chromoproteins derived from Anthopleura inornata, which have certain property, and fluorescent proteins from Trachyphyllia... | 12/02/2010 |
| 20100292454 | NEURONAL REGENERATION PROMOTING AGENT It is an object of the present invention to provide a novel neuronal regeneration promoting agent, particularly a neuronal regeneration promoting agent having an inhibitory effect on glial scar formation. The present invention provides a neuronal regeneration promoting ... | 11/18/2010 |
| 20100271618 | CARRIER CONCENTRATION MEASURING DEVICE AND CARRIER CONCENTRATION MEASURING METHOD A nondestructive carrier concentration measuring device (100) includes: a storage unit (101) that stores a correlation between the reflectance of an inorganic compound semiconductor against terahertz light and a carrier concentration; a light radiation uni... | 10/28/2010 |
| 20100239501 | GENE SENSITIVE TO BONE/JOINT DISEASE AND USE THEREOF The present invention provides a suppressing agent for inflammatory cytokine expression in joints and/or joint destruction (e.g., articular cartilage destruction) and/or pain in a bone/joint disease, comprising a substance that suppresses the expression or activity of a... | 09/23/2010 |
| 20100233684 | METHOD FOR DETERMINING INFLAMMATORY DISEASE It is an object of the present invention to provide a method for determining inflammatory diseases including myocardial infarction as a typical example, which involves identifying polymorphisms associated with myocardial infarction and using the gene polymorphisms, an o... | 09/16/2010 |
| 20100227383 | GENE DETECTION AND DETERMINATION APPARATUS, GENE REACTOR, AND INCUBATOR A genetic detection and determination apparatus which detects or determines genetic information, provided with a reaction container having a reaction vessel, including: a container set portion on which the reaction container is set; a moving mechanism which moves the co... | 09/09/2010 |
| 20100207136 | SAPPHIRE SUBSTRATE, NITRIDE SEMICONDUCTOR LUMINESCENT ELEMENT USING THE SAPPHIRE SUBSTRATE, AND METHOD FOR MANUFACTURING THE NITRIDE SEMICONDUCTOR LUMINESCENT ELEMENT The present invention provides an inexpensive substrate which can realize m-plane growth of a crystal by vapor phase growth. In a sapphire substrate, an off-angle plane slanted from an m-plane by a predetermined very small angle is prepared as a growth surface, which is... | 08/19/2010 |
| 20100200755 | APPARATUS AND METHOD FOR DETECTING TERAHERTZ WAVE A terahertz wave detecting apparatus includes a semiconductor chip 12, a two-dimensional graphene 14, a conductive source electrode 15, and a drain electrode 16 and a gate electrode 17. The two-dimensional graphene 14 is connect... | 08/12/2010 |
| 20100199387 | GENE HAVING ENDOREDUPLICATION PROMOTING ACTIVITY This invention is intended to identify a gene that regulates endoreduplication in a plant and to use such gene for breeding aimed at increasing the crop size. This invention provides a gene encoding an Arabidopsis thaliana-derived protein having an amino acid sequence a... | 08/05/2010 |
| 20100190159 | FLUORESCENCE-PRODUCING MOLECULE It is an object of the present invention to provide an on-off type fluorescent compound used in gene analyses, which is highly stable and highly sensitive, and which enables amplification of a trace amount of gene signal and observation thereof. The present invention pr... | 07/29/2010 |
| 20100151514 | NOVEL MUCIN-TYPE GLYCOPROTEIN AND USE THEREOF Provided is a novel mucin-type glycoprotein and a method for producing the same. Specifically, a mucin-type glycoprotein having a repeat structure including 3 to 2000 repeating units each having an amino acid sequence represented by the formula I: Val-Xaa-Glu-Thr-Thr-Al... | 06/17/2010 |
| 20100144078 | OPTICAL SEMICONDUCTOR DEVICE AND MANUFACTURING METHOD THEREFOR To provide an elemental technique for improving the emission intensity of deep ultraviolet light from a light emitting layer made of an AlGaInN-based material, in particular, an AlGaN-based material. First, an AlN layer is grown on a sapphire surface. The AlN layer is g... | 06/10/2010 |
| 20100078639 | THIN FILM SEMICONDUCTOR DEVICE FABRICATION METHOD AND THIN FILM SEMICONDUCTOR DEVICE The present invention provides a method for making a thin film semiconductor device having a bottom-gate, bottom-contact-type thin film transistor structure finer in size with satisfactory characteristics, in which the interface between a gate insulating film and a thin... | 04/01/2010 |
| 20100068807 | INTERFERON-alpha REGULATOR An object of the present invention is to elucidate the role of IKKα in TLR signaling and provide an agent and a method for controlling interferon-α. The present invention provides an agent for suppressing interferon-α production which comprises an agent for inhibitin... | 03/18/2010 |