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| Application No. | Application Title | Issue Date |
| 20120128707 | STREPTOCOCCUS PNEUMONIAE PROTEINS AND NUCLEIC ACIDS The invention provides proteins and nucleic acid sequences from Streptococcus Pneumoniae, together with a genome sequence. These are useful for the development of vaccines, diagnostics, and antibiotics.... | 05/24/2012 |
| 20120027813 | ADJUVANTED INFLUENZA VACCINES FOR PEDIATRIC USE An influenza vaccine adjuvanted with a sub-micron oil-in-water emulsion elicits significantly higher immune responses in human pediatric populations. Compared to an existing unadjuvanted pediatric influenza vaccine, the adjuvanted vaccines provided herein can induce in ... | 02/02/2012 |
| 20120020890 | STAPHYLOCOCCUS AUREUS PROTEINS AND NUCLEIC ACIDS The invention provides proteins from Staphylococcus aureus including amino acid sequences and the corresponding nucleotide sequences. The proteins are useful for vaccines, immunogenic compositions, diagnostics, enzymatic studies and also as targets for antibiotic... | 01/26/2012 |
| 20110195409 | STREPTOCOCCUS PYOGENES CLASSIFICATION The difference Lancefield T-serotypes correlate with the sequence of the pilus backbone protein (Pbp) in Streptococcus pyogenes (GAS). We have sequenced Pbp for over 50 GAS strains, representing the major disease-associated serotypes, and have identified 15 Pbp v... | 08/11/2011 |
| 20110189230 | VACCINATION WITH MULTIPLE CLADES OF H5 INFLUENZA A VIRUS H5N1 influenza viruses isolated from animals and humans since 2003 separate into distinct clades based on hemagglutinin amino acid sequences. According to the invention, multiple clades are used in influenza immunization. Thus there is a prime-boost immunization schedul... | 08/04/2011 |
| 20110166323 | CHIMERIC, HYBRID AND TANDEM POLYPEPTIDES OF MENINGOCOCCAL NMB1870 NMB1870 is a protein in Neisseria meningitidis. Three families of NMB1870 are known. To increase the ability of a NMB1870 protein to elicit antibodies that are cross-reactive between the families, NMB1870 is engineered. Sequences can be substituted from one NMB18... | 07/07/2011 |
| 20110104193 | COMBINATION NEISSERIAL COMPOSITIONS Compositions comprising a first biological molecule from a Neisseria bacterium and a second biological molecule from a Neisseria bacterium. The term “biological molecule” includes proteins and nucleic acids. Preferred Neisseria species are N.... | 05/05/2011 |
| 20110052620 | HYBRID POLYPEPTIDES COMPRISING GBS-80 AND SPB1 PROTEINS OF STREPTOCOCCUS GBS antigens GBS-80 and Spb1 are expressed in a single polypeptide chain, preferably with Spb1 upstream of GBS-80. Thus the invention provides a polypeptide comprising an amino acid sequence NH2—W—X-L-Y—Z—CO2H wherein: X is a Spb 1 sequence... | 03/03/2011 |
| 20100272755 | FERMENTATION PROCESSES FOR CULTIVATING STREPTOCOCCI AND PURIFICATION PROCESSES FOR OBTAINING CPS THEREFROM This invention is in the field of bacterial cultures and specifically relates to the optimization of culture conditions to improve the production of bacterial capsular polysaccharides from Streptococcus strains in fed batch culture and to novel purification metho... | 10/28/2010 |
| 20100233205 | ADJUVANTED ANTIGENIC MENINGOCOCCAL COMPOSITIONS Compositions comprising a Neisserial antigen and a detoxified ADP-ribosylating toxin are provided. These compositions have been found useful for mucosal immunization, particularly for nasal immunization against Neisseria meningitidis. ... | 09/16/2010 |
| 20100035285 | RAPID ELISA A step in the enzyme-linked immunosorbent assay (ELISA) is changed from a heterogeneous phase to a homogeneous phase, to give a much shorter overall completion time. The new assay comprises the steps of (i) mixing in a homogeneous phase a sample and a first binding part... | 02/11/2010 |
| 20090304742 | INFLUENZA VACCINES WITH REDUCED AMOUNT OF EMULSION ADJUVANT Influenza vaccines with oil-in-water emulsion adjuvants are known. The amount of emulsion adjuvant required for an influenza vaccine can be reduced, thereby allowing more vaccines to be made from a given amount of emulsion, and/or minimizing the amount of emulsion that ... | 12/10/2009 |
| 20090304739 | INFLUENZA VACCINES INCLUDING COMBINATIONS OF PARTICULATE ADJUVANTS AND IMMUNOPOTENTIATORS Influenza vaccines containing insoluble particulate adjuvants have been found to elicit an IgG response that is primarily a TH2 response (IgG1). This response can be shifted towards a TH1 response (IgG2a) by including immunopotentiators in the compositions. Thus the inv... | 12/10/2009 |
| 20090220547 | Reducing interference between oil-containing adjuvants and surfactant-containing antigens Inclusion of fatty adjuvants in vaccine compositions can cause difficulties with certain antigenic components, particularly with antigens that include a surfactant component. A method for preparing an immunogenic composition comprising an antigen and a fatty adjuvant in... | 09/03/2009 |
| 20090136547 | ZWITTERIONIZATION OF CAPSULAR SACCHARIDES Capsular saccharides are typically anionic. In the invention, however, cationic groups are introduced, such that the modified saccharide has a repeating unit which includes both cationic and anionic groups. These cationic and anionic groups can be balanced to give a zwi... | 05/28/2009 |
| 20090047353 | CHANGING TH1/TH2 BALANCE IN SPLIT INFLUENZA VACCINES WITH ADJUVANTS The invention seeks to avoid components in split vaccines that could cause an excessive Th2 response. Thus the invention provides an immunogenic composition comprising a split influenza virus antigen and a Th1 adjuvant, wherein the antigen is preferably prepared from a ... | 02/19/2009 |
| 20090047293 | Compositions Comprising Yersinia Pestis Antigens Disclosed are several Y. pestis antigens that are particularly suitable for immunisation purposes, particularly when used in combinations.... | 02/19/2009 |
