Assignee: Medimmune, LLC

Location: Gaithersburg, MD, US
No. of applications: 89

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Application No.	Application Title	Issue Date
20120109097	RECOMBINANT IL-9 ANTIBODIES AND USES THEREOF The present invention provides novel antibodies that immunospecifically bind to an IL-9 polypeptide and compositions comprising said antibodies. The present invention also provides methods and compositions preventing, treating, managing, and/or ameliorating diseases and...	05/03/2012
20120070447	METHODS OF ADMINISTERING / DOSING ANTI-RSV ANTIBODIES FOR PROPHYLAXIS AND TREATMENT The present invention encompasses novel antibodies and fragments thereof which immunospecifically bind to one or more RSV antigens and compositions comprising said antibodies and antibody fragments. The present invention encompasses methods preventing respiratory syncyt...	03/22/2012
20120046450	Modulation Of Antibody Effector Function By Hinge Domain Engineering The present invention relates to novel molecules (Fc variants) comprising at least one antigen binding region and an Fc region that further comprises a modified hinge which alters the binding of Fc to one or more Fc ligand (e.g., FcγRs) and/or modulates effector functi...	02/23/2012
20120045471	RECOMBINANT PARAINFLUENZA VIRUS VACCINE COMPRISING HETEROLOGOUS ANTIGENS DERIVED FROM RESPIRATORY SYNCYTIAL VIRUS The present invention relates to recombinant bovine parainfluenza virus (bPIV) cDNA or RNA which may be used to express heterologous gene products in appropriate host cell systems and/or to rescue negative strand RNA recombinant viruses that express, package, and/or pre...	02/23/2012
20120039876	STABILIZED LIQUID ANTI-RSV ANTIBODY FORMULATIONS The present invention provides liquid formulations of SYNAGIS® or an antigen-binding fragment thereof that immunospecifically bind to a respiratory syncytial virus (RSV) antigen, which formulations exhibit stability, low to undetectable levels of aggregation, and very ...	02/16/2012
20120034265	INFLUENZA HEMAGGLUTININ AND NEURAMINIDASE VARIANTS Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided....	02/09/2012
20120034264	INFLUENZA HEMAGGLUTININ AND NEURAMINIDASE VARIANTS Polypeptides, polynucleotides, methods, compositions, and vaccines comprising (avian pandemic) influenza hemagglutinin and neuraminidase variants are provided....	02/09/2012
20110280892	TOXIN CONJUGATED EPH RECEPTOR ANTIBODIES The present invention relates to compositions and methods for inducing cell death or stasis in cancer cells or other hyperproliferative cells using anti-EphA2 or anti-EphA4 antibodies conjugated to toxins....	11/17/2011
20110280869	METHODS OF PREVENTING OR TREATING INFLAMMATORY OR AUTOIMMUNE DISORDERS BY ADMINISTERING CD2 ANTAGONISTS IN COMBINATION WITH OTHER PROPHYLACTIC OR THERAPEUTIC AGENTS The present invention provides to methods of preventing, treating or ameliorating an autoimmune or inflammatory disorder or one or more symptoms thereof utilizing combinatorial therapy. In particular, the present invention provides methods of preventing, treating, or am...	11/17/2011
20110280868	METHODS OF PREVENTING OR TREATING T CELL MALIGNANCIES BY ADMINISTERING ANTI-CD2 ANTAGONISTS The present invention encompasses the use of a CD2 antagonist, preferably MEDI-507, an analog, derivative or an antigen-binding fragment thereof as a single agent therapy for the prevention, treatment, management, or amelioration of cancer, particularly a T-cell maligna...	11/17/2011
20120009199	ANTIBODY FORMULATIONS The present invention relates to formulations comprising sucrose, and methods of making such formulations, wherein the sucrose content promotes the reduction or elimination of the reversible self-association (RSA) tendency of the antibody in the formulation. The present...	01/12/2012
20110311454	MOLECULES WITH EXTENDED HALF-LIVES, COMPOSITIONS AND USES THEREOF The present invention provides molecules, including IgGs, non-IgG immunoglobulins, proteins and non-protein agents, that have increased in vivo half-lives due to the presence of an IgG constant domain, or a portion thereof that binds the FcRn, having one or more amino a...	12/22/2011
20110287023	High Affinity Antibodies Against HMGB1 and Methods of Use Thereof Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise, for example, high affinity antibodies that specifically b...	11/24/2011
20110256155	METHODS TO MOLECULARLY CHARACTERIZE CIRCULATING TUMOR CELLS The invention relates to a rapid, sensitive method to obtain a gene expression profile from a target cell population in a blood sample. The target cells can be circulating tumor cells. Disclosed are methods and kits for obtaining such profiles....	10/20/2011
20110256149	ANTIBODY FORMULATION The present invention provides high concentration liquid formulations of antibodies or fragments thereof that specifically bind to a human interferon alpha polypeptide The formulation provides for an anti-13H5 anti-human interferon alpha antibody A pre-filled syringe co...	10/20/2011
20110236406	IMMUNOGENIC COMPOSITIONS COMPRISING HMGB1 POLYPEPTIDES The present invention relates to novel immunogenic compositions (e.g., vaccines), the production of such immunogenic compositions and methods of using such compositions. More specifically, this invention provides unique immunogenic molecules comprising an HMGB1 polypept...	09/29/2011
20110158985	METHODS OF PREVENTING AND TREATING RSV INFECTIONS AND RELATED CONDITIONS The present invention provides methods for preventing, managing, treating and/or ameliorating a Respiratory Syncytial Virus (RSV) infection (e.g., acute RSV disease, or a RSV upper respiratory tract infection (URI) and/or lower respiratory tract infection (LRI)), otitis...	06/30/2011
20110130544	ANTIBODIES WITH DECREASED DEAMIDATION PROFILES The present invention relates to antibodies with decreased deamidation profiles, and methods for producing antibodies with decreased deamidation profiles....	06/02/2011
20110123559	SWINE INFLUENZA HEMAGGLUTININ VARIANTS Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided....	05/26/2011
20110091992	CRYSTALS AND STRUCTURE OF HUMAN IgG Fc VARIANT The present invention provides crystalline forms of a human IgG Fc variant comprising one or more amino acid residues that provides for enhanced effector function, methods of obtaining such crystals and high-resolution X-ray diffraction structures and atomic structure c...	04/21/2011
20110091453	METHODS OF ADMINISTERING/DOSING CD2 ANTAGONISTS FOR THE PREVENTION AND TREATMENT OF AUTOIMMUNE DISORDERS OR INFLAMMATORY DISEASES The present invention provides compositions for the prevention or treatment of an autoimmune disorder or an inflammatory disorder in a subject comprising one or more CD2 antagonists. In particular, the invention provides methods for preventing or treating an autoimmune ...	04/21/2011
20110077383	HINGE DOMAIN ENGINEERING The present invention relates to novel molecules (Fc variants) comprising at least one antigen binding region and an Fc region that further comprises a modified hinge which improves stability and/or alters the binding of Fc to one or more metal ion and/or one or more Fc...	03/31/2011
20110076752	ANTIBODY LIBRARY DISPLAY BY YEAST CELL PLASMA MEMBRANE The present invention relates to antibodies or antibody fragments that may be displayed on the extracellular surface of the plasma membrane when expressed in a host cell. The present invention provides libraries comprising a plurality of plasma membrane displayed antibo...	03/31/2011
20110070263	INFLUENZA HEMAGGLUTININ AND NEURAMINIDASE VARIANTS Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided....	03/24/2011
20110059486	NON-SPLICING VARIANTS OF GP350/220 Compositions comprising gp350 variant DNA and amino acid sequences are provided, as are vectors and host cells containing such sequences. Also provided is a process for producing homogeneous gp350 protein recombinantly and in the absence of production of gp220 protein, ...	03/10/2011
20110059100	C/CLP Antagonists And Methods Of Use Thereof The invention relates to the novel discovery that antagonizing a C/CLP can be useful for the treatment of diseases associated with the upregulation of one or more C/CLP such as Th2-driven and/or IL-13 mediated inflammatory diseases. Accordingly the present invention pro...	03/10/2011
20110053248	Serum-Free Virus Propagation Platform For A Virus Vaccine Candidate The invention relates to methods for propagating viruses. In particular, the invention provides optimized conditions for propagating viruses. Optimization of the following parameters are provided: lipid concentrates as supplements to the medium, temperature shift from p...	03/03/2011
20110052618	INFLUENZA HEMAGGLUTININ AND NEURAMINIDASE VARIANTS Polypeptides, polynucleotides, methods, compositions, and vaccines comprising (avian pandemic) influenza hemagglutinin and neuraminidase variants are provided....	03/03/2011
20110045586	METHODS AND COMPOSITIONS FOR EXPRESSING NEGATIVE-SENSE VIRAL RNA IN CANINE CELLS The present invention provides novel canine pol I regulatory nucleic acid sequences useful for the expression of nucleic acid sequences in canine cells such as MDCK cells. The invention further provides expression vectors and cells comprising such nucleic acids as well ...	02/24/2011
20110027272	STABILIZED LIQUID ANTI-RSV ANTIBODY FORMULATIONS The present invention provides liquid formulations of SYNAGIS® or an antigen-binding fragment thereof that immunospecifically bind to a respiratory syncytial virus (RSV) antigen, which formulations exhibit stability, low to undetectable levels of aggregation, and very ...	02/03/2011
20110002960	INFLUENZA HEMAGGLUTININ AND NEURAMINIDASE VARIANTS Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided....	01/06/2011
20100331208	Cell Display Of Antibody Libraries The present invention relates to a viral vector encoding for a library of antibodies or antibody fragments that are displayed on the cell membrane when expressed in a cell. The present invention provides cells comprising the viral vector nucleic acids and methods of scr...	12/30/2010
20100330118	INFLUENZA HEMAGGLUTININ AND NEURAMINIDASE VARIANTS Polypeptides, polynucleotides, reassortant viruses, immunogenic compositions and vaccines comprising influenza hemagglutinin and neuraminidase variants and method using thereof are provided....	12/30/2010
20100322969	INFLUENZA B VIRUSES HAVING ALTERATIONS IN THE HEMAGLUTININ POLYPEPTIDE The present invention encompasses methods of producing influenza B viruses in cell culture. The influenza B viruses may have desirable characteristics, such as enhanced replication in eggs and may be used, for example, in vaccines and in methods of treatment to protect ...	12/23/2010
20100303736	ANTI-IL-9 ANTIBODY FORMULATIONS AND USES THEREOF The present invention provides liquid formulations of antibodies or antibody fragments that immunospecifically bind to an IL-9 polypeptide, which formulations exhibit stability, low to undetectable levels of aggregation, and very little to no loss of the biological acti...	12/02/2010
20100298541	Protein Scaffolds The invention provides protein scaffolds and methods of preparing, screening, engineering and using such protein scaffolds....	11/25/2010
20100291073	METHODS OF REDUCING EOSINOPHIL LEVELS The present invention relates to a method of reducing the numbers of eosinophils in a human subject comprising administration to a subject an IL-5R binding molecule that comprises (a) a region that specifically binds to the IL-5R and (b) an immunoglobulin Fc region. In ...	11/18/2010
20100278852	ANTIBODIES AGAINST AND METHODS FOR PRODUCING VACCINES FOR RESPIRATORY SYNCYTIAL VIRUS The present invention relates to novel respiratory syncytial virus (RSV) F peptides and compositions comprising them. The present invention also relates to methods of evaluating anti-RSV antibody binding to F peptides. The present invention also relates to antibodies th...	11/04/2010
20100278838	EPHA2 MONOCLONAL ANTIBODIES AND METHODS OF USE THEREOF The present invention relates to methods and compositions designed for the treatment, management, or prevention of cancer, particularly, metastatic cancer. In one embodiment, the methods of the invention comprise the administration of an effective amount of an antibody ...	11/04/2010
20100266614	ULTRA HIGH AFFINITY NEUTRALIZING ANTIBODIES Ultra high affinity antibodies with binding affinities in the range of 10¹⁰M⁻¹, and even 10¹¹M⁻¹are disclosed. Such antibodies include antibodies having novel high affinity complementarity determining regions (CDRs), es...	10/21/2010

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Assignee: Medimmune, LLC