Assignee: Massachusetts Institute of Technology

Location: Not specified.
No. of applications: 85

Application No.	Application Title	Issue Date
20120107241	Particles for Inhalation Having Sustained Release Properties The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates...	05/03/2012
20120034296	PROLONGED DURATION LOCAL ANESTHESIA WITH MINIMAL TOXICITY Compositions containing site 1 sodium channel blockers for use as local anesthetics with rapid nerve block, improved potency and efficacy, and no local toxicity have been developed. Liposomes were employed for increased loading of the site 1 sodium channel blocker, prod...	02/09/2012
20120027808	NICOTINE IMMUNONANOTHERAPEUTICS The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that compr...	02/02/2012
20110268804	TARGETING OF ANTIGEN PRESENTING CELLS WITH IMMUNONANOTHERAPEUTICS The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that compr...	11/03/2011
20120010140	SELF-ASSEMBLING PEPTIDES FOR REGENERATION AND REPAIR OF NEURAL TISSUE The present invention provides methods and compositions for enhancing regeneration and/or repair of neural tissue. One method include providing a nanoscale structured material at the site of injury, wherein the nanoscale structured material provides an environment that ...	01/12/2012
20110298149	INORGANIC NANOWIRES An inorganic nanowire having an organic scaffold substantially removed from the inorganic nanowire, the inorganic nanowire consisting essentially of fused inorganic nanoparticles substantially free of the organic scaffold, and methods of making same. For example, a viru...	12/08/2011
20110286525	Selecting Transforms for Compressing Visual Data Encoding data includes: computing a first set of coefficients based on a plurality of transforms each computed over a different portion of an array of data, a second set of coefficients based on a plurality of transforms each computed over a different portion of the arr...	11/24/2011
20110229998	Blue light emitting semiconductor nanocrystal materials A semiconductor nanocrystal includes a core including a first semiconductor material and an overcoating including a second semiconductor material. A monodisperse population of the nanocrystals emits blue light over a narrow range of wavelengths with a high quantum effic...	09/22/2011
20110189677	Methods For Preparing Sequencing Libraries Improvements in chromatin immunoprecipitation-high throughput sequencing techniques has allowed the creation of chromatin maps from limited biological sample sizes that cannot be evaluated using conventional chromatin immunoprecipitation-sequencing protocols. For exampl...	08/04/2011
20110086922	SENSORY-SPECIFIC LOCAL ANESTHESIA AND PROLONGED DURATION LOCAL ANESTHESIA Combinations of charged local anesthetics with chemical permeation enhancers have been developed to give long duration block which is selective for sensory block over motor block. The duration of block is greatly prolonged by combining the local anesthetic with a permea...	04/14/2011
20110073003	Superhydrophilic coatings A superhydrophilic coating on a substrate can be antireflective and antifogging. The coating can remain antireflective and antifogging for extended periods. The coating can include oppositely charge inorganic nanoparticles, and can be substantially free of an organic po...	03/31/2011
20110037846	HIGH-RESOLUTION 3D IMAGING OF SINGLE SEMICONDUCTOR NANOCRYSTALS A method of imaging microscopic objects includes determining the relative depths of two or more semiconductor nanocrystals by analyzing images of the semiconductor nanocrystals at varying z-displacements....	02/17/2011
20110017950	Highly luminescent color-selective nanocrystalline materials A nanocrystal capable of light emission includes a nanoparticle having photoluminescence having quantum yields of greater than 30%....	01/27/2011
20100323199	POLYMERS FOR FUNCTIONAL PARTICLES The present invention generally relates to polymers and macromolecules, in particular, to block polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of emb...	12/23/2010
20100308275	Inorganic particle conjugates The ionic conjugates include an inorganic particle electrostatically associated with a macromolecule which can interact specifically with predetermined chemical species or biological targets....	12/09/2010
20100297233	OSCILLATING CELL CULTURE BIOREACTOR Methods and devices for cell or tissue culture are provided. One aspect provides a bioreactor having a gas permeable, closed-loop chamber for cell or tissue culture, and an oscillating means for moving the gas permeable, closed-loop chamber bidirectionally along an axis...	11/25/2010
20100291219	METHODS AND COMPOSITIONS RELATING TO PROGENITOR CELLS The invention provides compositions and methods for harvesting and enriching cells such as connective tissue progenitors cells using stirred bioreactors, and in some embodiments fibrin microcarriers....	11/18/2010
20100290520	SELECTING TRANSFORMS FOR COMPRESSING VISUAL DATA Encoding data includes: computing a first set of coefficients based on a plurality of transforms each computed over a different portion of an array of data, and a second set of coefficients based on a transform computed over the array of data; choosing a set of coeffici...	11/18/2010
20100264261	AIRCRAFT DRAG MANAGEMENT STRUCTURE Drag management structure. The structure includes a tube having an entrance and exit along a longitudinal axis. At least one row of stationary swirl generating vanes is provided at the entrance, the swirl vanes disposed at an angle with respect to the longitudinal axis ...	10/21/2010
20100240901	LIGHT EMITTING DEVICE INCLUDING SEMICONDUCTOR NANOCRYSTALS A light emitting device includes a semiconductor nanocrystal in a layer. The layer can be a non-polymeric layer....	09/23/2010
20100240101	Parallel Proximity Ligation Event Analysis The present invention describes compositions and methods showing that the spatial proximity of intracellular components may be related to their ability to cooperate in intracellular biochemical reactions. In some embodiments, the present invention contemplates a variety...	09/23/2010
20100221248	Directed Engagement of Activating Fc Receptors The present invention features engineered proteins that include a first polypeptide that specifically binds a first target (e.g., a cellular target, such as a cell-surface antigen) and a second polypeptide that selectively binds an activating FcR....	09/02/2010
20100184693	METHODS AND SYSTEMS FOR GENERATING AND EVALUATING PEPTIDES A method has been developed to create databases of peptides having a desirable property, such as antimicrobial activity, based on analyzing a database of known peptides for a pattern statistically associated with an activity. One can determine a set of patterns that may...	07/22/2010
20100165152	Processing Images Having Different Focus Processing images of a scene taken with different focus includes, for each of at least some of the images, determining at least one portion of the image having a predetermined characteristic. A representation of the scene is generated that includes an array of elements,...	07/01/2010
20100111540	FILTER-BASED DPSK RECEIVER A filter-based method of demodulating differentially encoded phase shift keyed (DPSK) optical signals, such as commonly used binary-DPSK (DBDPSK) and quadrature DPSK (DQPSK) signals, that can achieve optimal receiver sensitivity is described. This approach, which combin...	05/06/2010
20100102277	Stabilized semiconductor nanocrystals A semiconductor nanocrystal associated with a polydentate ligand. The polydentate ligand stabilizes the nanocrystal....	04/29/2010
20100076173	SYSTEMS AND METHODS FOR GENERATING PEPTIDES Antimicrobial peptides are small proteins used by the innate immune system to combat bacterial infection in multicellular eukaryotes. There is mounting evidence that these peptides are less susceptible to bacterial resistance than traditional antibiotics and that they m...	03/25/2010
20100022680	Microfluidic Synthesis of Organic Nanoparticles The present invention provides microfluidic systems and methods for the production of particles (e.g., nanoparticles) for drug delivery. The present invention provides microfluidic devices useful for production of particles by nanoprecipitation. The present invention pr...	01/28/2010
20090326177	Mesostructured Zeolitic Materials and Methods of Making and Using the Same One aspect of the present invention relates to mesostructured zeolites. The invention also relates to a method of preparing mesostructured zeolites, as well as using them as cracking catalysts for organic compounds and degradation catalysts for polymers....	12/31/2009
20090269619	Multifunctional biomaterials as scaffolds for electronic, optical, magnetic, semiconducting, and biotechnological applications One-dimensional ring structures from M13 viruses were constructed by two genetic modifications encoding binding peptides and synthesis of a heterobifunctional linker molecule. The bifunctional viruses displayed an anti-streptavidin peptide and hexahistidine (SEQ ID NO:4...	10/29/2009
20090162437	Modified self-assembling peptides The present invention provides a self-assembling peptide comprising: (a) a first amino acid domain that mediates self-assembly, wherein the domain comprises alternating hydrophobic and hydrophilic amino acids that are complementary and structurally compatible and self-a...	06/25/2009
20090090657	Mesostructured Zeolitic Materials and Methods of Making and Using the Same One aspect of the present invention relates to mesostructured zeolites. The invention also relates to a method of preparing mesostructured zeolites, as well as using them as cracking catalysts for organic compounds and degradation catalysts for polymers....	04/09/2009
20090081249	Bi-Functional Polymer-Attached Inhibitors of Influenza Virus Antimicrobial compositions containing two or more antiviral agents coupled to a polymer and methods of making and using the compositions, are described herein. In one embodiment, two or more antiviral agents are covalently coupled to the polymer. Suitable antiviral agen...	03/26/2009
20080244588	Computing the processor desires of jobs in an adaptively parallel scheduling environment The present invention describes a system and method for scheduling jobs on a multiprocessor system. The invention includes schedulers for use in both work-sharing and work-stealing environments. Each system utilizes a task scheduler using historical usage information, i...	10/02/2008
20080241531	VIRAL FIBERS Long rod shaped M13 viruses were used to fabricate one dimensional (1D) micro- and nanosized diameter fibers by mimic the spinning process of the silk spider. Liquid crystalline virus suspensions were extruded through the micrometer diameter capillary tubes in cross-lin...	10/02/2008
20080206885	Environmentally sensitive fluorophores The present invention provides novel fluorophore compounds....	08/28/2008
20080174233	Quantum dot white and colored light-emitting devices A light-emitting device comprising a population of quantum dots (QDs) embedded in a host matrix and a primary light source which causes the QDs to emit secondary light and a method of making such a device. The size distribution of the QDs is chosen to allow light of a p...	07/24/2008
20080171249	Thermally efficient micromachined device A micromachined device for efficient thermal processing at least one fluid stream includes at least one fluid conducting tube having at least a region with wall thickness of less than 50 μm. The device optionally includes one or more thermally conductive structures in ...	07/17/2008
20080085529	Fluorescence assay for kinase activity The present invention provides a sensor and methods for determining kinase activity. ...	04/10/2008
20080050761	Sox-based kinase sensor Peptidyl sensors comprise a metal-binding peptide and one or two kinase recognition sequences with a hydroxyamino acid that can be phosphorylated in the presence of a kinase....	02/28/2008

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Assignee: Massachusetts Institute of Technology