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Assignee: Government of the US, as represented by the Secretary, Department of Health and Human Services


Location: Rockville, MD, US
No. of applications: 15

Application No.Application TitleIssue Date
20110109313FAST ELECTRON PARAMAGNETIC RESONANCE IMAGING (EPRI) IN THE CW EPR MODE USING RAPID-SCAN IN THE PRESENCE OF ROTATING GRADIENTS AND DIRECT DETECTION WITH TRANSMIT/RECEIVE & DATA PROCESSING IN A DIGITAL SIGNAL PROCESSING PLATFORM
An electron paramagnetic resonance imaging system that includes means for continuously irradiating a sample with RF irradiation; means for imposing on the sample a sinusoidally varying magnetic field along with rotating gradients for spatial encoding; means for directly...
05/12/2011
20110008256MONOCLONAL ANTIBODIES THAT BIND OR NEUTRALIZE DENGUE VIRUS
The present invention relates to monoclonal antibodies that bind or neutralize dengue type 1, 2, 3, and/or 4 virus. The invention provides such antibodies, fragments of such antibodies retaining dengue virus-binding ability, fully human or humanized antibodies retaining...
01/13/2011
20100305025RNASE A PEPTIDES, FRAGMENTS AND USES THEREOF
The present invention features isolated polypeptides that have bactericidal and angiogenic activities. The invention features isolated polypeptides comprising amino acid sequences of RNase A ribonucleases, fragments and variants thereof, pharmaceutical compositions, and...
12/02/2010
20100266598PEPTIDE THAT ELICITS NEUTRALIZING ANTIBODIES TARGETING THE HIV CO-RECEPTOR, CCR5
The present invention relates, e.g., to an isolated peptide comprising a sequence of contiguous amino acids that is at least about 60% identical (e.g., at least about 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 98% or 100% identical) to the sequence E-W-Q-K-E-G-L-V-T-L-W-L ...
10/21/2010
20100252732DEVICE AND METHOD FOR DIRECT MEASUREMENT OF ISOTOPES OF EXPIRED GASES
The invention provides a device including a chamber wherein the chamber including a rigid enclosure; a rigid lid for the enclosure; a gasket between the lid and the enclosure to allow for an airtight seal between the enclosure and the gasket upon closure of a latch conn...
10/07/2010
20100247621CODON MODIFIED IMMUNOGENIC COMPOSITIONS AND METHODS OF USE
The present invention features immunogenic compositions comprising codon modified genes that encode viral proteins and/or glycoproteins or fragments. The immunogenic compositions of the invention are useful in various methods of treatment, such as preventing or treating...
09/30/2010
20100152301Treatment of Viral Infections
Treatment of cells or subjects (e.g., humans, animals) carrying or infected with a virus capable of causing an immunodeficiency disease by administration of one or more compounds that inhibit integrase....
06/17/2010
20100136514INFECTIOUS CLONE OF HUMAN PARVOVIRUS B19 AND METHODS
The invention relates to infectious clones of parvovirus B19, methods of cloning infectious B19 clones, and methods of cloning viral genomes that have secondary DNA structures that are unstable in bacterial cells. A B19 infectious clone and methods of producing B19 infe...
06/03/2010
20100069423Use of Chk2 Kinase Inhibitors for Cancer Treatment
Described herein are Chk2-inhibitor compounds and derivatives thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions thereof....
03/18/2010
20100016409Rna Nanoparticles and Nanotubes
The instant invention provides polyvalent RNA nanoparticles comprising RNA motifs as building blocks that can form RNA nanotubes. The polyvalent RNA nanoparticles are suitable for therapeutic or diagnostic use in a number of diseases or disorders....
01/21/2010
20090258002Biomarkers for Tissue Status
The invention relates to methods of accurately and quickly diagnosing and monitoring the progression of cancer and ischemally injured tissue. The invention also provides methods of treatment as well as methods of screening for compositions useful for treating the disord...
10/15/2009
20090131536Treating or Preventing Renal Cancer Using a Dimethane Sulfonate
The present invention features methods of treating renal cancer by administration of certain dimethylsulfonate compounds. The present invention further features administration protocols and dosing schedules for methods of treating patients suffering from renal cancer an...
05/21/2009
20090068234Methods and compositions for the treatment and prevention of cancer
The instant invention provides compositions for the treatment of cancer. Specifically, the invention provides polypeptides and nucleic acid molecules comprising tumor-associated embryonic antigens, e.g., OFA-iLRP, and chemoattractant ligands, e.g., a proinflammatory che...
03/12/2009
20090035763Methods for Detecting Progression of Low Grade Cervical Dysplasia and for Detecting Adenocarcinomas
The invention provides methods for identifying conditions of low grade cervical dysplasia and assessing the progressive potential of individual lesions to develop into high grade cervical dysplasia and cervical squamous cell cancer as well as cervical adenocarcinoma....
02/05/2009
20080311616Hydrophilic IR Transparent Membrane, Spectroscopic Sample Holder Comprising Same and Method of Using Same
The present invention features hydrophilic IR-transparent porous membranes, particularly hydrophilic IR-transparent porous polyethylene membranes and methods of preparing the hydrophilic membranes by treatment of hydrophobic IR-transparent porous membranes with plasma. ...
12/18/2008
 
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