Celebrity Inventors
Mark Twain (Samuel L. Clemens) received Patent No. 121,992 for "An Improvement in Adjustable and Detachable Straps for Garments." He later received two more patents: one for a self-pasting scrapbook and one for a game to help players remember important historical dates.
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| Application No. | Application Title | Issue Date |
| 20120083625 | PREPARATION OF IODIXANOL A process for the preparation of iodixanol by dimerisation of 5-acetamido-N,N′-bis (2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide (“Compound A”) in which, after the dimerisation step, unreacted Compound A is precipitated from the reaction mixture and recovered... | 04/05/2012 |
| 20120020882 | PEPTIDE-BASED COMPOUNDS The invention relates to new peptide-based compounds for use as diagnostic imaging agents or as therapeutic agents wherein the agents comprise targeting vectors which bind to integrin receptors.... | 01/26/2012 |
| 20110263975 | FLUORESCENT PROBES HAVING A POLYMERIC BACKBONE The present invention relates to quenched fluorescent probes which arc activated by biochemical processes. The probes are designed such that intramolecular quenching occurs in the unactivated probe, but that the quencher moieties are cleaved from the probe under defined... | 10/27/2011 |
| 20110318273 | FLUORESCENT CONTRAST AGENTS The invention relates to contrast agents for imaging of diseases associated with inflammations. More specifically the invention provides optical imaging contrast agents for imaging of activated leukocytes and methods for imaging of such. The contrast agent changes its f... | 12/29/2011 |
| 20110207963 | PREPARATION OF IODIXANOL A process for the preparation of iodixanol by dimerisation of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide (“Compound A”) in which, after the dimerisation step, unreacted Compound A is precipitated from the reaction mixture and recovered ... | 08/25/2011 |
| 20110021834 | CONTINUOUS PROCESS OF PREPARING INTERMEDIATE FOR NON-IONIC X-RAY CONTRAST AGENTS This invention relates to an improved method for the synthesis of 5-amino-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (Compound B), an intermediate in the industrial preparation of non-ionic X-ray contrast agents. In particular, it relates to a continuou... | 01/27/2011 |
| 20110021833 | CRYSTALLIZATION OF AN INTERMEDIATE FOR SYNTHESIZING NON-IONIC X-RAY CONTRAST AGENTS This invention relates generally to the crystallization process of 5-amino-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide (“Compound B”), an iodinated intermediate in the preparation of non-ionic X-ray contrast agents. The instant process uti... | 01/27/2011 |
| 20110021832 | SYNTHESIS OF IODIXANOL IN WATER This invention relates to the synthesis of iodixanol (1,3-bis(acetamido)-N,N′-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the dimerisation of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isoph... | 01/27/2011 |
| 20110021831 | SYTNHESIS OF IODIXANOL IN 1-METHOXY-2-PROPANOL AND WATER OR METHANOL This invention relates to the synthesis of iodixanol (1,3-bis(acetamido)-N,N′-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the dimerisation of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isoph... | 01/27/2011 |
| 20110021830 | SYTNHESIS OF IODIXANOL IN PROPYLENEGLYCOL This invention relates to the synthesis of iodixanol (1,3-bis(acetamido)-N,N′-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the dimerisation of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isoph... | 01/27/2011 |
| 20110021829 | SYTNHESIS OF IODIXANOL IN METHANOL This invention relates to the synthesis of iodixanol (1,3-bis(acetamido)-N,N′-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the dimerisation of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isoph... | 01/27/2011 |
| 20110021828 | RECOVERING UNREACTED INTERMEDIATE FROM DESALINATED AND DESOLVENTIZED DIMERISATION REACTION MIXTURE BY ULTRAFILTRATION This invention relates generally to industrial preparation of iodixanol (1,3-bis(acetamido)-N,N′-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), a non-ionic X-ray contrasting agent. It further relates to a method of recovering int... | 01/27/2011 |
| 20110021827 | CRYSTALLIZATION OF IODIXANOL USING ULTRASOUND This invention relates to the manufacture of iodixanol (1,3-bis(acetamido)-N,N′-bis[3,5-bis (2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the purification of iodixanol by crystallization by using ultrasound.... | 01/27/2011 |
| 20110021826 | CRYSTALLIZATION OF IODIXANOL USING MILLING This invention relates to the manufacture of iodixanol(1,3-bis(acetamido)-N,N′-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the purification of iodixanol by crystallization by using wet milling.... | 01/27/2011 |
| 20110021825 | PROCESS FOR ISOLATING IODIXANOL FROM AN AQUEOUS SOLUTION This invention relates to the isolation of iodixanol (1,3-bis(acetamido)-N,N′-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the isolation of iodixanol from an aqueous solution.... | 01/27/2011 |
| 20110021824 | ADSORPTIVE PURIFICATION METHOD FOR IODIXANOL This invention relates generally to non-ionic X-ray contrast agents. It further relates to a method of using solid adsorbents to reduce backpeaks content in the purification of iodixanol. In particular, it relates to the use of non-polar organic adsorbents with the aver... | 01/27/2011 |
| 20110021823 | PROCESSING CRUDE IODIXANOL MIXTURE BY NANOFILTRATION This invention relates generally to industrial preparation of iodixanol (1,3-bis(acetamido)-N,N′-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), a non-ionic X-ray contrasting agent. It further relates to a method for preparing a c... | 01/27/2011 |
| 20110021822 | CONTINUOUS DEACETYLATION AND PURIFICATION PROCESS IN SYNTHESIS OF NON-IONIC X-RAY CONTRAST AGENTS This invention relates to an improved method for the synthesis of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (“Compound A”), an intermediate in the industrial preparation of non-ionic X-ray contrast agents. In particular, it relates to a... | 01/27/2011 |
| 20110021821 | CONTINUOUS ACETYLATION PROCESS IN SYNTHESIS OF NON-IONIC X-RAY CONTRAST AGENTS This invention relates to an improved method for the synthesis of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (“Compound A”), an intermediate in the industrial preparation of non-ionic X-ray contrast agents. In particular, it relates to a... | 01/27/2011 |
| 20110021814 | METHOD FOR REDUCING AMINOISOPHTHALIC ACID BISAMIDE RELATED IMPURITIES IN PREPARATION OF NON-IONIC X-RAY CONTRAST AGENTS This invention relates generally to the preparation of non-ionic X-ray contrast agents, iohexol, ioversol, and iodixanol. It further relates to a method for improving the purity of 5-amino-N,N′-bis(2,3-dihydroxypropyl)-isophthalamide (or ABA), an intermediate in the i... | 01/27/2011 |
| 20110020238 | STABILIZING AQUEOUS SOLUTION OF IODINE CHLORIDE BY ADDING SODIUM CHLORIDE This invention relates generally to non-ionic X-ray contrast agents. It further relates to the preparation of iodine chloride, a key reagent in the synthesis of non-ionic X-ray contrast agents such as iodixanol and iohexol. In particular, the iodine chloride is produced... | 01/27/2011 |
| 20110017673 | ENDOTOXIN REMOVAL IN CONTRAST MEDIA This invention relates to the manufacture of contrast media, and more specifically to the removal of endotoxins in such contrast media.... | 01/27/2011 |
| 20100234611 | Fluorination Process of Anilide Derivatives and Benzothiazole Fluorinate Derivatives as in VIVO Imaging Agents The invention relates to a process for preparation of a compound of formula (I): R1 is selected from C1-6alkyl, C2-6alkenyl, and C2-6alkynyl; which comprises: (i) reaction with fluoride, suitably [18F]fluoride, of a... | 09/16/2010 |
| 20100111865 | CONTRAST AGENTS The present invention provides novel compounds and pharmaceutical compositions containing such compounds, wherein the compounds have affinity for proteoglycans. The compounds comprise an amino acid based core unit linked to positively charged moieties. The compounds fur... | 05/06/2010 |
| 20100076199 | PROCESS FOR THE PREPARATION OF SUBSTITUTED PYRIDONE CARBOXYLIC ACIDS The present invention relates to methods for the preparation of pyridone carboxylic acids for use as intermediates in the preparation of various synthetic organic compounds. The pyridone carboxylic acids can for example be used as intermediates in the production of pote... | 03/25/2010 |
| 20100069669 | Preparation of Iodixanol A process for the preparation of iodixanol by dimerisation of 5-acetamido-N,N′-bis(2,3-dihydroxypropy1)-2,4,6-triiodo-isophthalamide (“Compound A”) in which, after the dimerisation step, unreacted Compound A is precipitated from the reaction mixture and recovered ... | 03/18/2010 |
| 20100056787 | CHELATING AGENTS The present invention relates to chelating agents, in particular to chelating agents which are capable of forming complexes with paramagnetic metal ions such as iron (III) and gadolinium (III). The invention also relates to the complexes formed and their use as MRI cont... | 03/04/2010 |
| 20090155184 | MAGNETIC RESONANCE IMAGING METHOD The present invention relates to a magnetic resonance imaging (MRI) method, in particular to a MRI method enabling early detection of myocardial ischemia.... | 06/18/2009 |
| 20090118540 | Method For Producing Pyruvic Acid The invention relates to a method for the production of pyruvic acid.... | 05/07/2009 |
| 20090004119 | Polymers The present invention relates to novel linear polymers, compositions comprising said polymers and their use as contrast agents in magnetic resonance (MR) imaging (MRI) and magnetic resonance spectroscopy (MRS).... | 01/01/2009 |
| 20080287711 | Purification of Iodixanol A process for the manufacture of iodixanol by performing a purification process of the crude product in a solvent comprising ethanol. The crude product may be obtained in aqueous solution from dimerisation of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-iso... | 11/20/2008 |
| 20080267881 | IMAGING AGENTS The invention relates to compounds of formula (I): and their use as targeting vectors that bind to receptors associated with angiogenesis. Such compounds may thus be used for diagnosis or therapy of, for example, malignant diseases, heart diseases, endometriosis, inflam... | 10/30/2008 |
| 20080260651 | CONTRAST AGENTS The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing an aliphatic N-heteroc... | 10/23/2008 |
| 20080214867 | Continuous Crystallisation Process of Iodinated Phenyl Derivatives The invention describes a process for the purification of iodinated aryl compounds where the purification is performed by continuous crystallisation of a crude product in a solvent with addition of anti-solvent. The continuous crystallisation process is performed in one... | 09/04/2008 |
| 20080187493 | Peptide-Based Compounds The invention relates to new peptide-based compounds for use as diagnostic imaging agents or as therapeutic agents wherein the agents comprise a targeting vector which binds to receptors associated with integrin receptors.... | 08/07/2008 |
