Mark Twain (Samuel L. Clemens) received Patent No. 121,992 for "An Improvement in Adjustable and Detachable Straps for Garments." He later received two more patents: one for a self-pasting scrapbook and one for a game to help players remember important historical dates.
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| Application No. | Application Title | Issue Date |
| 20080257437 | MICROFABRICATED FLUIDIC CIRCUIT ELEMENTS AND APPLICATIONS Microfabricated fluidic devices of the present invention include switches that can be opened and closed to allow or block the flow of fluid through a channel in response to the pressure level in a gate of the switch. The microfabricated fluidic switches may be coupled t... | 10/23/2008 |
| 20080230387 | Microfluidic Devices and Methods of Using Same A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at the en... | 09/25/2008 |
| 20080075380 | Methods and systems for image processing of microfluidic devices A method of processing data associated with fluorescent emissions from a microfluidic device. The method includes performing an auto-focus process associated with a first image of the microfluidic device and performing an auto-exposure process associated with the first ... | 03/27/2008 |
| 20080075322 | Methods and systems for determining a baseline during image processing A method of determining a plurality of positions associated with a plurality of reaction chambers of a microfluidic device includes a) providing a baseline image; b) providing a template image of a reaction chamber; and c) selecting a region of the baseline image. The m... | 03/27/2008 |
| 20070196912 | INTEGRATED CHIP CARRIERS WITH THERMOCYCLER INTERFACES AND METHODS OF USING THE SAME Methods and systems are provided for conducting a reaction at a selected temperature or range of temperatures over time. An array device is provided. The array device contains separate reaction chambers and is formed as an elastomeric block from multiple layers. At leas... | 08/23/2007 |
| 20070138076 | Devices and methods for microfluidic chromatography Embodiments of the invention provide devices, methods and systems for performing microfluidic chromatography. Particular embodiments provide microfluidic chromatography column devices which can perform chemical separation using small sample volumes and low pressure diff... | 06/21/2007 |
| 20070074972 | Microfluidic assay devices and methods A microfluidic device adapted to perform many simultaneous binding assays including but not limited to immunological experiments, such as ELISA assays, with minimal cross-talk between primary and secondary antibodies. ... | 04/05/2007 |
| 20070004033 | MICROFLUIDIC DEVICE AND METHODS OF USING SAME A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at the en... | 01/04/2007 |
| 20070004031 | MICROFLUIDIC DEVICE AND METHODS OF USING SAME A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at the en... | 01/04/2007 |
| 20060281183 | Analysis engine and database for manipulating parameters for fluidic systems on a chip Systems for managing workflows to perform chemical or biological reactions using microfluidic devices. ... | 12/14/2006 |
| 20060129138 | Drug delivery system An implantable drug delivery system has a housing, a collapsible reservoir, a microfabricated flow channel, and at least one magnet. The collapsible reservoir is disposed in the housing. The microfabricated flow channel is connected at one end to the collapsible reservo... | 06/15/2006 |
| 20060118895 | Electrostatic/electrostrictive actuation of elastomer structures using compliant electrodes A valve structure comprises an elastomeric block formed with first and second microfabricated recesses separated by a membrane portion of the elastomeric block. The valve is actuated by positioning a compliant electrode on a first side of the first recess proximate to a... | 06/08/2006 |
| 20060093836 | Polymer surface modification The present invention is directed to a surface modified polymer comprising a surface which is covalently bonded to a surface modifying compound. Formation of the covalent bond between the polymer and the surface modifying compound is achieved by a reaction between an in... | 05/04/2006 |
| 20060036416 | Computer aided design method and system for developing a microfluidic system The present invention generally relates to design automation techniques and more particularly to the design of customized microfluidic systems using a microfluidic computer aided design system. In one embodiment of the present invention the system includes a synthesis m... | 02/16/2006 |
| 20060024751 | Scale-up methods and systems for performing the same The present invention provides methods of and systems for translating conditions from a small-volume experiment to a larger-volume experiment. ... | 02/02/2006 |
| 20060006067 | Optical lens system and method for microfluidic devices An apparatus for imaging one or more selected fluorescence indications from a microfluidic device. The apparatus includes an imaging path coupled to least one chamber in at least one microfluidic device. The imaging path provides for transmission of one or more fluoresc... | 01/12/2006 |
| 20060000513 | Microfabricated fluidic circuit elements and applications The present invention provides microfabricated fluidic systems and methods. Microfabricated fluidic devices of the present invention include switches that can be opened and closed to allow or block the flow of fluid through a channel in response to the pressure level in... | 01/05/2006 |
| 20050282175 | Image processing method and system for microfluidic devices A method for processing an image of a microfluidic device. The method includes receiving a first image of a microfluidic device. The first image corresponds to a first state. Additionally, the method includes receiving a second image of the microfluidic device. The seco... | 12/22/2005 |
| 20050252773 | Thermal reaction device and method for using the same An M×N matrix microfluidic device for performing a matrix of reactions, the device having a plurality of reaction cells in communication with one of either a sample inlet or a reagent inlet through a via formed within an elastomeric block of the device. Methods provide... | 11/17/2005 |
| 20050224351 | Microfluidic devices for introducing and dispensing fluids from microfluidic systems The present invention provides microfluidic devices, systems and methods for using the same, which facilitate the introduction of fluid to and from a microfluidic channel located within the microfluidic devices. ... | 10/13/2005 |
| 20050214173 | Integrated chip carriers with thermocycler interfaces and methods of using the same Methods and systems are provided for conducting a reaction at a selected temperature or range of temperatures over time. An array device is provided. The array device contains separate reaction chambers and is formed as an elastomeric block from multiple layers. At leas... | 09/29/2005 |
| 20050197652 | Drug delivery system An implantable drug delivery system has a housing, a collapsible reservoir, a microfabricated flow channel, and at least one magnet. The collapsible reservoir is disposed in the housing. The microfabricated flow channel is connected at one end to the collapsible reservo... | 09/08/2005 |
| 20050129581 | Microfluidic devices and methods of using same A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at the en... | 06/16/2005 |
| 20050118073 | Devices and methods for holding microfluidic devices Carriers or holders for holding microfluidic devices are provided. Some of the carriers that are provided include a hydration control device and/or a source of controlled fluid pressure to facilitate use of the carrier in conducting various types of analyses. ... | 06/02/2005 |
| 20050084421 | Microfluidic devices and methods of using same An M×N matrix microfluidic device for performing a matrix of reactions, the device having a plurality of reaction cells in communication with one of either a sample inlet or a reagent inlet through a via formed within an elastomeric block of the device. Methods provide... | 04/21/2005 |
| 20050065735 | Microfluidic design automation method and system The present invention generally relates to microfluidics and more particularly to the design of customized microfluidic systems using a microfluidic computer aided design system. In one embodiment of the present invention a microfluidic circuit design method is provided... | 03/24/2005 |
| 20050022889 | Microfabricated fluidic circuit elements and applications The present invention provides microfabricated fluidic systems and methods. Microfabricated fluidic devices of the present invention include switches that can be opened and closed to allow or block the flow of fluid through a channel in response to the pressure level in... | 02/03/2005 |
| 20050019794 | Crystal growth devices and systems, and methods for using same High throughput screening of crystallization of a target material is accomplished by simultaneously introducing a solution of the target material into a plurality of chambers of a microfabricated fluidic device. The microfabricated fluidic device is then manipulated to ... | 01/27/2005 |
| 20050019792 | Microfluidic device and methods of using same A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at the en... | 01/27/2005 |
| 20050000900 | Microfluidic chromatography The present invention is directed to a microfluidic chromatography apparatus comprising a microfabricated fluid delivery system and a chromatography column which is in fluid communication with the fluid delivery system, and a method for producing and using the same. Pre... | 01/06/2005 |