Did You Know...
...that several people are credited with the invention of the flush toilet? Most people have heard of Thomas Crapper (1837-1910), the sanitary engineer who invented the valve-and-siphon arrangement that made the modern toilet possible. Another claimant to "the throne" was British inventor Alexander Cumming who patented a toilet in 1775. Then there's a nameless Minoan (a native of ancient Crete) who lived 4,000 years ago who supposedly was ahead of his time and created the first flush toilet!
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| Application No. | Application Title | Issue Date |
| 20120129883 | BENZENESULFONYL OR SULFONAMIDE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO THE MODULATION OFTHE SEROTONIN 5-HT6 RECEPTOR The present invention relates to benzenesulfonyl or sulfonamide compounds of formulae IA and IB wherein the variables have the meanings given in the claims and the description, pharmaceutical compositions con... | 05/24/2012 |
| 20120129853 | METHODS OF TREATMENT USING SELECTIVE BCL-2 INHIBITORS This invention pertains to methods of treating systemic lupus erythematosus, lupus nephritis or Sjogren's Syndrome with compounds that selectively inhibit the activity of Bcl-2 anti-apoptotic proteins. Specifically, the current invention is directed to treatment with co... | 05/24/2012 |
| 20120129727 | EFFICIENT AND EFFECTIVE SUPPLEMENT SCREENING FOR THE DEVELOPMENT OF CHEMICALLY DEFINED MEDIA IN CELL CULTURE The present invention relates to methods of selecting and developing a chemically defined media (“CDM”) for use in the manufacture of biological products. In particular, the present invention is directed to screening methods to determine cell culture technique media... | 05/24/2012 |
| 20120129196 | HIGHLY SENSITIVE MONOCLONAL ANTIBODY RESIDUAL DETECTION ASSAY The present invention relates to compositions and highly sensitive methods for the detection of biotechnology product residual when monitoring product carry over and/or for cleaning verification in the manufacture of biotechnology products. In particular, the present in... | 05/24/2012 |
| 20120108637 | Fused Bicyclic-Substituted Amines as Histamine-3 Receptor Ligands Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 r... | 05/03/2012 |
| 20120108590 | MELT-EXTRUDED SOLID DISPERSIONS CONTAINING AN APOPTOSIS-INDUCING AGENT A pro-apoptotic solid dispersion comprises, in essentially non-crystalline form, a Bcl-2 family protein inhibitory compound of Formula I as defined herein, dispersed in a solid matrix that comprises (a) a pharmaceutically acceptable water-soluble polymeric carrier and (... | 05/03/2012 |
| 20120083499 | NOVEL BENZENESULFONAMIDES AS CALCIUM CHANNEL BLOCKERS The present application relates to calcium channel inhibitors comprising compounds of formula (I), formula (II), formula (III), or formula (IV), wherein L1, R1, R2, R3 | |
| 20120083490 | CYTOCHROME P450 OXIDASE INHIBITORS AND USES THEREOF The present invention features compounds of formula I or pharmaceutically acceptable salts, solvates or prodrugs thereof, and methods of using the same to inhibit the metabolizing activities of CYP enzymes. T... | 04/05/2012 |
| 20120082646 | Antiviral Compounds And Uses Thereof This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compou... | 04/05/2012 |
| 20120071651 | Processes for Preparing 1,2-Substituted Cyclopropyl Derivatives The present invention relates to processes for preparing enantiomerically pure cyclopropyl amine derivatives and salts thereof; the chiral intermediates such as the chiral salts are useful for the preparation of such chiral compounds and salts; pharmaceutical compositio... | 03/22/2012 |
| 20120071334 | Methods And Marker Combinations For Screening For Predisposition To Lung Cancer The present invention relates to rapid, sensitive methods for determining whether a subject has or is at risk of developing lung cancer based on certain combinations of biomarkers, or biomarkers and biometric parameters. The methods consist of: a) quantifying in a test ... | 03/22/2012 |
| 20120053345 | Indazole Compounds Novel compounds of Formula (I) or pharmaceutically acceptable salts, prodrugs and biologically active metabolites thereof of Formula (I) wherein the substituents are as defined herein, which are useful as the... | 03/01/2012 |
| 20120046303 | BENZIMIDAZOLE POLY(ADP RIBOSE)POLYMERASE INHIBITORS Compounds which inhibit the activity of poly(ADP-ribose)polymerase (PARP), compositions containing the compounds and methods of treating diseases using them are disclosed.... | 02/23/2012 |
| 20120045524 | COMBINATION THERAPY WITH PARP INHIBITORS The present invention describes benzimidazole derivatives of Formula (I) which constitute potent PARP inhibitors in combination with radiotherapy or in combination with other chemotherapeutic agents.... | 02/23/2012 |
| 20120040969 | N-PHENYL-(PIPERAZINYL OR HOMOPIPERAZINYL)-BENZENESULFONAMIDE OR BENZENESULFONYL-PHENYL-(PIPERAZINE OR HOMOPIPERAZINE) COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE SEROTONIN 5-HT6 RECEPTOR The present invention relates to N-phenyl-(piperazinyl or homopiperazinyl)-benzenesulfonamide or benzenesulfonyl-phenyl-(piperazine or homopiperazine) compounds, pharmaceutical compositions containing them, and their use in therapy. The compounds possess valuable therap... | 02/16/2012 |
| 20120040948 | AMINOINDANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY The present invention relates to aminoindane derivatives of the formula (I) or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comp... | 02/16/2012 |
| 20120040947 | TETRALINE AND INDANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY The present invention relates to tetraline and indane derivatives of the formula (I) or a physiologically tolerated salt thereof. The invention relates to pharmaceutical composit... | 02/16/2012 |
| 20120039900 | BIOMARKERS PREDICTIVE OF THE RESPONSIVENESS TO TNFALPHA INHIBITORS IN AUTOIMMUNE DISORDERS The invention provides methods for predicting responsiveness to TNFα inhibitors in a subject suffering from an autoimmune disorder, such as rheumatoid arthritis. The methods involve assaying for expression of one or more biomarkers in the subject that are predictive of... | 02/16/2012 |
| 20120028925 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.... | 02/02/2012 |
| 20120028908 | Methods of Manufacturing Crystalline Forms of Rapamycin Analogs A process for preparing a crystalline rapamycin analog includes: combining the rapamycin analog with an organic medium to form a mixture; incubating the mixture until the rapamycin analog crystallizes; and recovering the crystalline rapamycin analog. The organic medium ... | 02/02/2012 |
| 20110281900 | Crystalline Pharmaceutical New crystalline forms of lopinavir are disclosed.... | 11/17/2011 |
| 20110281870 | NOVEL SUBSTITUTED OCTAHYDROCYCLOPENTA[C]PYRROL-4-AMINES AS CALCIUM CHANNEL BLOCKERS The present application relates to calcium channel inhibitors containing compounds of formula (I) wherein L1, L2, R1, R2, and R3 are as defined in the sp... | 11/17/2011 |
| 20110281868 | INDAZOLE INHIBITORS OF KINASE The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein A1, A2, A3 and L are defined in the description. The present invention re... | 11/17/2011 |
| 20110281842 | PYRROLOPYRIDINE AND PYRROLOPYRIMIDINE INHIBITORS OF KINASES The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein A, B, R1, R2, R3, R4a, R5, and Z are defined in the... | 11/17/2011 |
| 20110281258 | Human Immunodeficiency Virus And Uses Thereof The present invention relates to Human Immunodeficiency Virus-1 (HIV-1) Group P of the strain designated 06CMU14788 and fragments thereof, primers which are derived from HIV-1 Group P, immunogenic regions thereof, immunoassays and nucleic acid based assays for the detec... | 11/17/2011 |
| 20120022253 | INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of tre... | 01/26/2012 |
| 20120022252 | PHOSPHINE LIGANDS FOR CATALYTIC REACTIONS The disclosure is directed to: (a) phosphacycle ligands; (b) methods of using such phosphacycle ligands in bond forming reactions; and (c) methods of preparing phosphacycle ligands.... | 01/26/2012 |
| 20120022103 | ANTAGONISTS OF THE TRPV1 RECEPTOR AND USES THEREOF The present application is directed to compounds that are TRPV1 antagonists and have formula (I) wherein variables Ar1, L1, R1, R2, R3, R4, R<... | 01/26/2012 |
| 20120022089 | Solid Pharmaceutical Dosage Form A solid pharmaceutical dosage form providing improved oral bioavailability is disclosed for inhibitors of HIV protease. In particular, the dosage form comprises a solid dispersion of at least one HIV protease inhibitor and at least one pharmaceutically acceptable water-... | 01/26/2012 |
| 20110280800 | IL-1 BINDING PROTEINS Proteins that bind IL-1α and IL-1β are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1α and IL-1β in cells, tissues, samples, and compositions.... | 11/17/2011 |
| 20120020972 | ANTIBODIES RELATING TO PIVKA-II AND USES THEREOF The present disclosure relates to antibodies and immunoassay methods for use in the diagnosis, treatment and prevention of hepatocellular carcinoma (HCC), liver cancer and related conditions.... | 01/26/2012 |
| 20110275630 | ISOINDOLINONE KINASE INHIBITORS Compounds having the formula: are useful for inhibiting protein kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment u... | 11/10/2011 |
| 20110275064 | METHOD FOR HEMATOLOGY ANALYSIS A method whereby one or more fluorescent dyes are used to bind and stain nucleic acids in certain blood cells, such as, for example, white blood cells, nucleated red blood cells, and reticulocytes, and to induce fluorescent emissions upon excitation of photons from a gi... | 11/10/2011 |
| 20110273547 | STAGGERED CONTACT IMAGE SENSOR IMAGING SYSTEM A method and an apparatus for imaging a biologic sample is provided. The apparatus includes at least one light source, at least one lens array, at least one image detector, a positioning system, and an image processor. The lens array has a plurality of lengthwise extend... | 11/10/2011 |
| 20110269708 | P2X7 ANTAGONISTS TO TREAT AFFECTIVE DISORDERS The present invention provides methods to treat mood disorders and anxiety disorders using antagonists of the P2X7 receptor and pharmaceutical compositions thereof, or combinations.... | 11/03/2011 |
| 20110263827 | Dual Variable Domain Immunnoglobulins and Uses Thereof The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.... | 10/27/2011 |
| 20110263436 | RECOMBINANT ANTIBODIES AGAINST HEPATITIS C VIRUS AND METHODS OF OBTAINING AND USING SAME Recombinant antibodies, including chimeric antibodies, specific for hepatitis C (HCV) antigenic proteins are provided. The recombinant antibodies specifically bind to diagnostically relevant regions of HCV proteins and are thus suitable for use, for example, as diagnost... | 10/27/2011 |
| 20110262924 | MOLECULAR ASSAY FOR DIAGNOSIS OF HIV TROPISM The invention is directed to compositions, methods and kits for HIV subtypes in a test sample, wherein target sequence are amplified. The amplified target sequences are then analyzed by any number of mass spectrometric techniques, which data are queried against a databa... | 10/27/2011 |
| 20110259847 | BOTTLE PACKAGING FOR FLOWABLE PRODUCT A bottle packaging includes a groove on the neck of a bottle with the groove spaced longitudinally from a shoulder of the bottle a distance greater than or equal to a width of the groove, and upper and lower portions of the neck may have outer transverse cross-sectional... | 10/27/2011 |
| 20120015963 | NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS The present disclosure is directed to novel compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variables are ... | 01/19/2012 |
