US Patent Application 20100221242 - ANTI-VIRAL GRIFFITHSIN COMPOUNDS, COMPOSITIONS AND METHODS OF USE
InventorsUS Classes424/130.1, IMMUNOGLOBULIN, ANTISERUM, ANTIBODY, OR ANTIBODY FRAGMENT, EXCEPT CONJUGATE OR COMPLEX OF THE SAME WITH NONIMMUNOGLOBULIN MATERIAL514/12, 25 or more peptide repeating units in known peptide chain structure514/16, 7 or 8 peptide repeating units in known peptide chain514/15, 9 to 11 peptide repeating units in known peptide chain514/14, 12 to 15 peptide repeating units in known peptide chain514/13, 16 to 24 peptide repeating units in known peptide chain424/93.2, Genetically modified micro-organism, cell, or virus (e.g., transformed, fused, hybrid, etc.)424/93.21, Eukaryotic cell435/235.1VIRUS OR BACTERIOPHAGE, EXCEPT FOR VIRAL VECTOR OR BACTERIOPHAGE VECTOR; COMPOSITION THEREOF; PREPARATION OR PURIFICATION THEREOF; PRODUCTION OF VIRAL SUBUNITS; MEDIA FOR PROPAGATINGAttorney, Agent or FirmInternational ClassesA61K 39/395A61K 38/16 A61K 38/08 A61K 38/10 A61K 35/74 A61K 35/12 A61K 31/7052 C12N 7/00 A61P 31/12 Issued Patent Number:8088729Abstract textA method of inhibiting a viral infection of a host comprising administering to the host an anti-viral griffithsin polypeptide comprising SEQ ID NO: 3 or a fragment thereof comprising at least eight contiguous amino acids, a nucleic acid encoding the anti-viral polypeptide, or an antibody to the anti-viral polypeptide. A method of inhibiting a virus in a sample comprising contacting the sample with an anti-viral griffithsin polypeptide or antibody thereto also is provided. |
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