US Patent Application 20100069484 - SIGMA(s)-RECEPTOR LIGANDS WITH ANTI-APOPTOTIC AND/OR PRO-APOPTOTIC PROPERTIES OVER CELLULAR BIOCHEMICAL MECHANISMS, WITH NEUROPROTECTIVE, ANTI-CANCER, ANTI-METASTATIC AND ANTI-(CHRONIC) INFLAMMATORY ACTION
InventorUS Classes514/472, The nitrogen bonded directly to the hetero ring549/328, Four-membered lactone ring formed549/480, Nitrogen bonded directly to the hetero ring564/305, Benzene ring containing514/449, Oxygen containing hetero ring514/646Benzene ring containingAttorney, Agent or FirmForeign Documents
International ClassesA61K 31/341C07D 305/10 C07D 307/22 C07C 211/00 A61K 31/365 A61P 29/00 A61P 35/00 Abstract textThe present invention involves new and original sigma receptors ligands : (Mono- or di-alkylaminoalkyl)-γ-butyrolactones, their analogues aminotetrahydrofuranes, the (1-adamantyl)phenyl(s) alkylamines, the N,N Dialkyl α-[(adamantyl-1)benzyloxy-2] alkylamines and the 3-cyclopentyl adamantyl-amines or alkylamines or -alkyl phenylamines, their enantiomers or diastereoisomers and their pharmaceutically acceptable salts, with pro-apoptotic and/or anti-apoptotic properties over cellular bio-chemical mechanisms, with anti-cancer, anti-metastatic, anti-(chronic) inflammatory, neuro-protective, anticonvulsive, antidepressive and nooanaleptic or sedative action. |
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