US Patent Application 20100068730 - METHOD FOR SCREENING ANTI-CANCER COMPOUNDS INHIBITING FUNCTION OF TM4SF5 AND ANTI-CANCER COMPOSITION CONTAINING CHALCONE COMPOUNDS
InventorsAssigneeUS Classes435/7.8, Involving nonmembrane bound receptor binding or protein binding other than antigen-antibody binding435/15, Involving transferase435/18, Involving hydrolase564/95, Substituent Q is acyclic558/57Alicyclic ring attached directly or indirectly to the sulfonate group by nonionic bondingAttorney, Agent or FirmForeign Documents
International ClassesG01N 33/53C12Q 1/48 C12Q 1/34 C07C 311/00 C07C 309/63 Abstract textThe present invention relates to a method for screening an anticancer compound and an anticancer compound screened using the method, and more particularly, to a method for screening an anticancer compound, the method comprising: culturing cancer cells expressing the oncogenic protein transmembrane 4 L6 family member 5 (TM4SF5), expressed as the polypeptide of SEQ ID NO: 2, treating the cancer cells with an anticancer candidate, and determining that the anticancer candidate is an anticancer substance when the candidate exhibits antagonistic activity against tumor formation and metastasis based on several events through the molecular mechanism of TM4SF5. The present invention also relates to chalcone compounds screened to have anticancer activity using the method, and an anticancer composition comprising the compound as an effective ingredient. |
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