US Patent Application 20100068272 - HYDROXYAMIDINE AND HYDROXYGUANIDINE COMPOUNDS AS UROKINASE INHIBITORS
InventorsAssigneeUS Classes424/474, Coated pills or tablets514/255.01, Nitrogen or -C(=X)-, wherein X is chalcogen, bonded directly to the piperazine ring544/387, Plural -C(=X)- groups bonded directly to the piperazine ring514/604, Q is monocyclic564/92Benzene ring in a substituent EAttorney, Agent or FirmForeign Documents
International ClassesA61K 9/28A61K 31/495 C07D 241/04 A61K 31/18 C07C 311/00 A61P 35/00 Abstract textThe present invention relates to novel compounds for inhibiting the urokinase plasminogen activator (uPA), which have high bioavailability and oral administerability, and also to the use thereof as therapeutic active compounds for the treatment of urokinase- or/and urokinase receptor-associated disorders such as, for example, tumors and metastasizing. The invention relates in particular to compounds containing hydroxyamidine or hydroxyguanidine groups. |
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