US Patent Application 20100063287 - PROCESS FOR PREPARING 2-AMINO-5-CYANOBENZOIC ACID DERIVATIVES
InventorAssigneeUS Classes546/4, The metal bonded directly to carbon, which carbon is a ring carbon of the six-membered hetero ring or which carbon is attached directly or indirectly to the six-membered hetero ring by nonionic bonding564/161, Substituent Q contains benzene ring558/390Nitrogen in the acyclic chainAttorney, Agent or FirmInternational ClassesC07F 15/04C07C 233/65 C07C 255/63 Issued Patent Number:8034968Abstract textDisclosed is a method for preparing a compound of Formula 1 comprising (1) contacting a compound of Formula 2, with (2) at least one alkali metal cyanide and (3) at least one compound of Formula 4 wherein R1 is NHR3 or OR4; R2 is CH3 or Cl; R3 is H, C1-C4 alkyl, cyclopropyl, cyclopropylcyclopropyl, cyclopropylmethyl or methylcyclopropyl; R4 is H or C1-C4 alkyl; and X is Br, Cl or I. Also disclosed is a method for preparing a compound of Formula 4 comprising contacting a mixture of (i) at least one compound of Formula 9 and (ii) at least one metal reducing agent with (iii) dichlorobis(triphenylphosphine)nickel, and further disclosed is a method for removing nickel impurities from a mixture thereof with compounds of Formula 1 comprising contacting the mixture with oxygen in the presence of an aqueous cyanide solution, and additionally disclosed is a method for preparing a compound of Formula 5 wherein R5, R6, R7 and Z are as defined in the disclosure, using a compound of Formula 1, characterized by preparing the compound of Formula 1 by the method disclosed above. |
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