US Patent Application 20100063160 - POLYMORPHS OF O-DESMETHYL VENLAFAXINE SUCCINATE
InventorsAssigneeUS Classes514/649, Amino nitrogen attached to aryl ring or aryl ring system by an acyclic carbon or acyclic chain564/360Additional hydroxy, bonded directly to carbon, or ether oxygen attached directly or indirectly to the acyclic carbon or chain by acyclic nonionic bonding with no amino nitrogen between the additional hydroxy or ether oxygen and the aryl ring or ring system (H of -OH may be replaced by a substituted or unsubstitited ammonium ion or a Group IA or IIA light metal)Attorney, Agent or FirmForeign Documents
International ClassesA61K 31/137C07C 215/42 A61P 25/24 A61P 25/22 Abstract textThe present invention relates to crystalline forms of O-desmethyl venlafaxine (ODV) succinate monohydrate, namely Forms I and II, in pure form and to novel processes for their preparation. The present invention provides a process for the preparation of Form II free of Form I and a process for the preparation of Form I free of Form II. The present invention provides direct methods for the preparation of ODV succinate Form II from ODV free base and for the preparation of ODV succinate Form I from ODV free base. |
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