US Patent Application 20100063076 - Endothelin receptor antagonists
InventorUS Classes514/269, Pyrimidines with chalcogen bonded directly to a ring carbon of said pyrimidine moiety544/296, Plural 1,3-diazine rings560/61, Oxy, bonded directly to a ring, in same side chain as ester function564/90Substituent Q is monocyclicAttorney, Agent or FirmInternational ClassesA61K 31/506C07D 403/04 A61P 9/12 A61P 9/10 C07C 69/76 C07C 311/16 Issued Patent Number:8080549Abstract textThis invention relates to novel endothelin receptor antagonists, derivatives, acceptable acid addition salts thereof. The invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by compounds that block the endothelin signaling pathway that leads to vasoconstriction and in particular those diseases or conditions beneficially treated by endothelin receptor antagonists. |
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