US Patent Application 20100062465 - Detection of Histone Deacetylase Inhibition
Inventors
US Classes435/18, Involving hydrolase560/159, Additional nitrogen in acid moiety556/87, Carbon bonded directly to the metal564/158Hydroxy, bonded directly to carbon, or ether containing (H of -OH may be replaced by a substituted or unsubstituted ammonium ion or a Group IA or IIA light metal)Attorney, Agent or FirmInternational ClassesC12Q 1/34C07C 271/10 C07F 7/22 C07C 233/01 Abstract textProvided are compositions and methods for intracellular detection of enzyme activity. One example of a composition is a histone deacetylase substrate comprising a compound of the following formula (I): One example of a method is a method for detecting histone deacetylase activity comprising introducing a compound according to formula (1) to a plurality of cells and monitoring the cells with magnetic resonance spectroscopy. |
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