US Patent Application 20100055184 - HYDROGELS FOR VOCAL CORD AND SOFT TISSUE AUGMENTATION AND REPAIR
InventorsUS Classes424/484, Matrices568/679, Polyether568/852, Polyhydroxy530/402, Chemical modification or the reaction product thereof, e.g., covalent attachment or coupling, etc.536/123.1, Polysaccharides536/55.1, Polysaccharides536/51, Dextran derivatives530/354, Gelatin530/353, Scleroproteins, e.g., fibroin, elastin, silk, etc.530/356, Collagen536/30, Cellulose derivatives424/93.1, WHOLE LIVE MICRO-ORGANISM, CELL, OR VIRUS CONTAINING424/93.7, Animal or plant cell514/2, Peptide containing (e.g., protein, peptones, fibrinogen, etc.) DOAI514/1225 or more peptide repeating units in known peptide chain structureAttorney, Agent or FirmInternational ClassesA61K 9/00C07C 43/11 C07C 31/18 C07K 14/00 C08B 37/00 C08B 37/02 C08B 37/04 C07K 14/78 A61P 19/04 C08B 15/06 A61K 35/00 A61K 35/12 A61K 38/02 A61K 38/16 A61K 31/7052 Abstract textThe present invention provides hydrogels and compositions thereof for vocal cord repair or augmentation, as well as other soft tissue repair or augmentation (e.g., bladder neck augmentation, dermal fillers, breast implants, intervertebral disks, muscle-mass). The hydrogels or compositions thereof are injected into the superficial lamina propria or phonatory epithelium to restore the phonatory mucosa of the vocal cords, thereby restoring a patient's voice. In particular, it has been discovered that hydrogels with an elastic shear modulus of approximately 25 Pa are useful in restoring the pliability of the phonatory mucosa. The invention also provides methods of preparing and using the inventive hydrogels. |
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