US Patent Application 20100047327 - Adjuvant for Transdermal or Transmucosal Administration and Pharmaceutical Preparation Containing the Same
InventorsUS Classes424/449, Transdermal or percutaneous435/235.1, VIRUS OR BACTERIOPHAGE, EXCEPT FOR VIRAL VECTOR OR BACTERIOPHAGE VECTOR; COMPOSITION THEREOF; PREPARATION OR PURIFICATION THEREOF; PRODUCTION OF VIRAL SUBUNITS; MEDIA FOR PROPAGATING424/209.1, Orthomyxoviridae (e.g., influenza virus, fowl plague virus, etc.)568/840, Acyclic562/512, Acyclic560/129, Acyclic acid moiety514/513, C-C(=X)-X-C containing (X is chalcogen and at least one X is other than oxygen)514/558, Higher fatty acid or salt thereof514/724C-O-group (e.g., alcohol, alcoholate, etc.) DOAIAttorney, Agent or FirmForeign Documents
International ClassesA61K 9/70C12N 7/01 A61K 39/145 C07C 31/02 C07C 53/126 C07C 69/02 A61K 31/215 A61K 31/20 A61K 31/045 A61P 37/04 Abstract textIt is intended to provide a low molecular weight adjuvant which can be administered safely without inducing skin irritation or the like by transdermal or transmucosal administration and is for enhancing immunogenicity of an antigen efficiently. It can be achieved by an immunostimulant adjuvant containing at least one substance selected from the group consisting of aliphatic alcohols, free fatty acids and fatty acid derivatives but does not contain a substance represented by the following formula. (In the formula, R3 and R4 may be combined to form a cyclic ring, and R1 and R2 independently represent an alkyl side chain having 1 to 16 carbon atoms.) |
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