US Patent Application 20090297559 - USE OF TIGHT JUNCTION AGONISTS TO FACILITATE PULMONARY DELIVERY OF THERAPEUTIC AGENTS
InventorsUS Classes424/209.1, Orthomyxoviridae (e.g., influenza virus, fowl plague virus, etc.)424/184.1, ANTIGEN, EPITOPE, OR OTHER IMMUNOSPECIFIC IMMUNOEFFECTOR (E.G., IMMUNOSPECIFIC VACCINE, IMMUNOSPECIFIC STIMULATOR OF CELL-MEDIATED IMMUNITY, IMMUNOSPECIFIC TOLEROGEN, IMMUNOSPECIFIC IMMUNOSUPPRESSOR, ETC.)424/212.1, Measles virus or mumps virus424/219.1, Rubella virus424/232.1, Poxviridae (e.g., smallpox virus, avian pox virus, fowlpox virus, rabbit myxoma virus, vaccinia virus, etc.)424/245.1, Corynebacterium (e.g., Corynebacterium diphtheriae, etc.)424/246.1, Bacillus424/247.1, Clostridium (e.g., Clostridium tetani, Clostridium difficile, Clostridium perfringens, Clostridium botulinum, Clostridium chauvoei, etc.)424/253.1, Bordetella (e.g., Bordetella bronchiseptica, etc.)424/254.1, Bordetella pertussis424/256.1, Hemophilus (e.g., Hemophilus influenzae, Hemophilus gallinarum, Hemophilus pleuropnemoniae, etc.)514/4, With an additional active ingredient514/15, 9 to 11 peptide repeating units in known peptide chain514/16, 7 or 8 peptide repeating units in known peptide chain514/175 or 6 peptide repeating units in known peptide chainAttorney, Agent or FirmInternational ClassesA61K 39/00A61K 39/145 A61K 39/165 A61K 39/20 A61K 39/275 A61K 39/05 A61K 39/07 A61K 39/08 A61K 39/10 A61K 39/102 A61K 38/28 A61K 38/08 A61P 37/00 Abstract textThe present invention provides materials and methods to facilitate the pulmonary delivery of therapeutic agents. In some embodiments, agonists of tight junctions (e.g., zonulin agonists) are used in compositions to facilitate the uptake of therapeutic agents from the pulmonary mucosa. |
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