US Patent Application 20090047353 - CHANGING TH1/TH2 BALANCE IN SPLIT INFLUENZA VACCINES WITH ADJUVANTS

Application 20090047353 Filed on November 6, 2006. Published on February 19, 2009

Abstract Claims Description Full Text

Inventor

O'Hagan, Derek

Assignee

Novartis Vaccines and Diagnostics SRL

US Classes

424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)424/206.1Influenza virus

Attorney, Agent or Firm

NOVARTIS VACCINES AND DIAGNOSTICS INC.

International Classes

A61K 9/14
A61K 39/00
A61P 31/00

Abstract text

The invention seeks to avoid components in split vaccines that could cause an excessive Th2 response. Thus the invention provides an immunogenic composition comprising a split influenza virus antigen and a Th1 adjuvant, wherein the antigen is preferably prepared from a virus grown in cell culture (e.g., it is free from egg proteins).

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