US Patent Application 20060276416 - Methods and compositions for treating flushing and drug induced weight gain
InventorsAssigneeUS Classes514/27, Oxygen of the saccharide radical bonded directly to a nonsaccharide hetero ring or a polycyclo ring system which contains a nonsaccharide hetero ring514/456, Bicyclo ring system having the hetero ring as one of the cyclos (e.g., chromones, etc.)514/171, With additional active ingredient514/220, Tricyclo ring system having the seven-membered hetero ring as one of the cyclos514/369, Chalcogen bonded directly to ring carbon of the thiazole ring514/342, Ring sulfur in the additional hetero ring514/733, Acyclic carbon to carbon unsaturation514/317, Additional ring containing514/649, Amino nitrogen attached to aryl ring or aryl ring system by an acyclic carbon or acyclic chain514/3Insulin or derivativeAttorney, Agent or FirmInternational ClassesA61K 31/7048A61K 31/57 A61K 31/56 A61K 31/551 A61K 31/426 A61K 31/353 A61K 38/28 A61K 31/445 A61K 31/44 A61K 31/137 Abstract textProvided herein are methods and compositions for treating and/or preventing flushing and/or weight gain. Methods may comprise modulating the activity or level of a sirtuin, such as SIRT1 or Sir2. Exemplary embodiments include methods and compositions for counteracting drug-induced weight gain and/or drug-induced flushing by administering a sirtuin-activating compound. |
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