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| Application No. | Application Title | Issue Date |
| 20050186622 | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro or in vivo recombination is described. In particular, a method for the production of nucleic acid fragments or polynucleotides encoding mutan... | 08/25/2005 |
| 20050186623 | Isolating cells expressing secreted proteins A method for identifying and isolating cells which produce secreted proteins. This method is based upon a specific characteristic or the expression level of the secreted protein by transiently capturing the secreted protein on the surface of an individual cell, allowing... | 08/25/2005 |
| 20050186624 | Method of detection in vitro of a target substance in a sample comprising the labelling of said substance with a reporter gene and with the sequences necessary for the expression of said reporter gene in vitro The present invention relates to a method of detection in vitro of a target substance in a sample. The sample can comprise, among other things, a nucleic sequence or more generally any type of substance. In particular, the present invention provides a method of detectio... | 08/25/2005 |
| 20050186625 | Process and system for sharing program fragments A technique for sharing code fragments involves detecting identical code fragments, then replacing code fragments with references to an identical code fragment. A process according to the technique may include detecting identical code fragments in one or more modules, p... | 08/25/2005 |
| 20050186626 | Chicken leukemia inhibitory factor (LIF) and gene thereof The present invention is to provide a chicken LIF gene. Based on this genetic information, LIF protein derived from the chicken can be stably supplied and it solves the problems of the creation of transgenic chickens in the past. In addition, the present invention provi... | 08/25/2005 |
| 20050186627 | Cloned peripheral nerve, tetrodotoxin-resistant sodium channel alpha-subunit The present invention relates to a voltage-gated sodium channel present in peripheral nerve tissue that is tetrodotoxin-resistant. One aspect of the present invention is purified and isolated DNA encoding this sodium channel. Another aspect of the present invention is t... | 08/25/2005 |
| 20050186628 | Dorsalin-1 polypeptide and uses thereof This invention provides an isolated vertebrate nucleic acid molecule which encodes dorsalin-1. This invention also provides a nucleic acid probe capable of specifically hybridizing with a sequence included within the sequence of a nucleic acid molecule encoding a dorsal... | 08/25/2005 |
| 20050186629 | Nanopore device and methods of fabricating and using the same Nanopore devices including microfluidic introduction members and methods of using the same are provided. The subject devices include first and second fluid containment members separated by a fluid barrier having a single nanopore therein providing fluid communication be... | 08/25/2005 |
| 20050186630 | Extended tethering approach for rapid identification of ligands The invention concerns a method for rapid identification and characterization of binding partners for a target molecule, and for providing binding partners with improved binding affinity. More specifically, the invention concerns an improved tethering method for the rap... | 08/25/2005 |
| 20050186631 | Nematode PPPT-like sequences Disclosed are a nucleic acid molecule from nematodes encoding for purine/pyrimidine phosphoribosyl transferase (PPPT) polypeptides. The PPPT-like polypeptide sequence is also provided, as are vectors, host cells, and recombinant methods for production of PPPT-like nucle... | 08/25/2005 |
| 20050186632 | Transcription activator The invention provides a synthesis-inducible eucaryotic promoter having a transcriptional activity comprising, for example, a heavy metal-sensitive DNA sequence, derived from a natural promotor, of a base sequence of any one of SEQ ID NOS: 1 to 4; an inducer of the tran... | 08/25/2005 |
| 20050186633 | In vitro gastrointestinal model system and uses thereof A system utilizing cell immobilization in anaerobic continuous-flow cultures for modelling the gastrointestinal system is described. Microbial cells derived from flora, e.g. in fresh faecal samples, are used as the source of inocula for immobilisation in a mixed gel of ... | 08/25/2005 |
| 20050186634 | Peptides for use in culture media The present invention provides peptides libraries which are useful for rapid identification of biologically active compounds. The invention further provides peptides which include cell-growth affecting peptides and peptides which enhance or inhibit production of cellula... | 08/25/2005 |
| 20050186635 | Electroactive surface-confinable molecules The invention provides compositions, kits, methods, and species that include electroactive entities which can serve as signaling entities in chemical and/or biochemical assays. The electroactive species can be metallocenes, such as ferrocenes, including substituents tha... | 08/25/2005 |
| 20050186636 | Method of rational-based drug design using osteocalcin The invention relates to a method of identifying a compound that affects osteocalcin activity, comprising obtaining a 3D structure of osteocalcin or a fragment thereof, designing a compound to interact with, or mimic, the 3D structure of osteocalcin or fragment thereof,... | 08/25/2005 |
| 20050186637 | Neutrokine-alpha and neutrokine-alpha splice variant The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host ... | 08/25/2005 |
| 20050186638 | Method for the screening of alpha2beta-1 subunit binding ligands A method for the screening of ligands which bind to soluble α2δ-1 subtype polypeptides. ... | 08/25/2005 |
| 20050186639 | Gene originating in human chondrocyte This invention provides a gene specifically expressed in differentiated human chrondrocytes. By culturing the chrondrocytes in the presence of dibutyryl cAMP, the chrondrocytes are cultured in a differentiated state and any gene is searched for which has a distinction i... | 08/25/2005 |
| 20050186640 | Novel anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RYR2) The present invention provides novel 1,4-benzothiazepine intermediates and derivatives, methods for synthesizing same, and methods for assaying same. The present invention also provides methods for using these novel compounds to limit or prevent a decrease in the level ... | 08/25/2005 |
| 20050186641 | LABELING OF IMMOBILIZED PROTEINS USING DIPYRROMETHENEBORON DIFLUORIDE DYES The invention describes methods for labeling or detecting of immobilized poly(amino acids), including peptides, polypeptides and proteins, on membranes and other solid supports, using fluorescent dipyrrometheneboron difluoride dyes. Such immobilized poly(amino acids) ar... | 08/25/2005 |
| 20050186642 | Immunoassay reagents and methods of use thereof The present invention provide reagents and methods of using the reagents, for example, on automated staining devices, that facilitate detection of two or more antigens in a sample simply and efficiently. ... | 08/25/2005 |
| 20050186643 | Pin1 as a marker for abnormal cell growth Methods for the use of Pin1 as a marker of abnormal cell growth are disclosed. In one embodiment, the method includes detecting a level of Pin1 to stage an abnormal cell growth, such as breast or prostate cancer. In another embodiment, the method includes evaluating the... | 08/25/2005 |
| 20050186644 | Antibody to bladder cancer nuclear matrix protein and its use Nuclear matrix proteins (NMP) which are characterized by a defined expression in tissue are provided. These NMPs are useful markers in diagnosing and monitoring the stage of malignancy of a cell and treating cell proliferative disorders associated with the NMP. Also pro... | 08/25/2005 |
| 20050186645 | Method for analyzing a glycomolecule The invention relates generally the structural analysis of glycomolecule-containing macromolecules, such as those that occur either attached to proteins (proteoglycans, glycoproteins), lipids, or as free saccharides. ... | 08/25/2005 |
| 20050186646 | Rapid assay to detect ADAMTS-13 activity The present invention is directed to an assay for ADAMTS-13 activity. The assay provides rapid analysis of ADAMTS-13 activity in a biological sample under non-denaturing conditions. Furthermore, the present invention is directed to a recombinant polypeptide with a funct... | 08/25/2005 |
| 20050186647 | Methods for identifying or monitoring a patient with increased risk of cardiovascular calcification The present invention includes novel methods of using a calcification risk index (CRI) for identifying or monitoring a patient with increased risk of cardiovascular calcification and/or mortality, or monitoring an effect of therapeutic treatment for a patient having car... | 08/25/2005 |
| 20050186648 | OCT based method for diagnosis and therapy This invention relates to a method of diagnosing or treating a biological subject, such as a person or animal, comprising the steps of subjecting at least a microsample of the subject's tissue to a physiological perturbation and measuring the response of the microsample... | 08/25/2005 |
| 20050186649 | Inhibitors of human plasmin derived from the kunitz domains This invention provides: novel proteins, which are homologous to the first Kunitz domain (K1) of lipoprotein-associated coagulation inhibitor (LACI), and which are capable of inhibiting plasmin; uses of such novel proteins in therapeutic, diagnostic, and clinical method... | 08/25/2005 |
| 20050186650 | Pharmaceuticals and methods for treating hypoxia and screening methods therefor Light-generating fusion proteins having a ligand binding site and a light-generating polypeptide moiety and their use as diagnostics, in drug screening and discovery, and as therapeutics, are disclosed. The light-generating fusion protein has a feature where the biolumi... | 08/25/2005 |
| 20050186651 | Fluorescently labeled thiol-containing trapping agent for the quantitation and identification of reactive metabolites in vitro The present application relates to a sensitive and quantitative method using dansylated glutathione as a trapping agent for the detection of reactive metabolites in the field of drug discovery. The fluorescent tag attached to the dansylated glutathione does not impede t... | 08/25/2005 |
| 20050186652 | Electrochemical detection A method for detecting the presence or absence of, or for determining the concentration of, a substrate in a sample is provided, wherein the method comprises
| 08/25/2005 |
| 20050186653 | Compositions and methods for screening antibacterial compounds The present invention pertains to compositions and methods used to ascertain if putative antibiotics trigger a cell envelope stress response in bacterial organisms. In one aspect of the invention, three two-component systems are described: LiaR & LiaS (formerly YvqCE); ... | 08/25/2005 |
| 20050186654 | Method for producing dipeptide A method for producing a dipeptide including the step of exposing a carboxy component and an amine component to an enzyme having an activity to hydrolyze amino acid ester. Such a hydrolase has been found among enzymes in bacteria. The method is useful for producing a pe... | 08/25/2005 |
| 20050186655 | Preparation containing cell extracts for cell-free protein synthesis and means for synthesizing protein using the preparation Disclosed are a preparation containing cell extracts for cell-free protein synthesis, prepared by excluding from a living organism a system, participating to inhibiting of self protein synthesis reaction, an apparatus for cell-free protein synthesis reaction equipped wi... | 08/25/2005 |
| 20050186656 | Glycoprotein synthesis Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatu... | 08/25/2005 |
| 20050186657 | Glycoprotein synthesis Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatu... | 08/25/2005 |
| 20050186658 | Chimeric metabotropic glutamate receptors and uses thereof The present invention provides chimeric receptors that include an extracellular domain from a metabotropic glutamate receptor and a non-native signal peptide, e.g., a calcium receptor signal peptide. The invention also includes methods of preparing such chimeric recepto... | 08/25/2005 |
| 20050186659 | Methods for protein purification The present invention relates to process for the production of a soluble polypeptide having at least one ligand binding site, the process comprising (i) providing a host cell comprising a nucleic acid sequence encoding the soluble polypeptide; (ii) culturing the host ce... | 08/25/2005 |
| 20050186660 | Human procalcitonin and the preparation and use thereof The invention relates to human procalcitonin and the preparation and use thereof. In particular, a process for preparing human procalcitonin is described wherein a gene coding for a polypeptide comprising the amino acid sequence of human procalcitonin is inserted into a... | 08/25/2005 |
| 20050186661 | Production of protease from Bacillus stearothermophilus F1 A biologically pure strain of Bacillus stearothermophilus F1 capable of Producing protease which is tolerant to any organic compound selected from the group leucine, cysteine, arginine, glycine, asparagine (BDH) and aspartic acid. Peptone iv derived from soybean ... | 08/25/2005 |
